Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 GeneticVariation disease BEFREE We performed a retrospective analysis of 22 patients with epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer who exhibited 1st/2nd generation EGFR-tyrosine kinase inhibitors resistance. 29848710 2018
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 Biomarker disease BEFREE Dichotomous ALK-IHC Is a Better Predictor for ALK Inhibition Outcome than Traditional ALK-FISH in Advanced Non-Small Cell Lung Cancer. 28183714 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 GeneticVariation disease BEFREE Association Between Environmental Tobacco Smoke Exposure and the Occurrence of EGFR Mutations and ALK Rearrangements in Never-smokers With Non-Small-cell Lung Cancer: Analyses From a Prospective Multinational ETS Registry. 28433570 2018
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 Biomarker disease BEFREE Precision medicine in ALK rearranged NSCLC: A rapidly evolving scenario. 29458783 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 GeneticVariation disease BEFREE EGFR-mutated non-small cell lung cancer patients experience relapse within 1-2 years of treatment with EGFR-inhibitors, such as erlotinib. 28418902 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 GeneticVariation disease BEFREE Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) is the most important limiting factor for treatment efficiency in EGFR-mutant non-small cell lung cancer (NSCLC). 28515374 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 GeneticVariation disease BEFREE Patterns of initial and intracranial failure in metastatic EGFR-mutant non-small cell lung cancer treated with erlotinib. 28625621 2018
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.700 Biomarker disease BEFREE BRAF in non-small cell lung cancer (NSCLC): Pickaxing another brick in the wall. 29729495 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 GeneticVariation disease BEFREE Superior Treatment Response and In-field Tumor Control in Epidermal Growth Factor Receptor-mutant Genotype of Stage III Nonsquamous Non-Small cell Lung Cancer Undergoing Definitive Concurrent Chemoradiotherapy. 28131636 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 GeneticVariation disease BEFREE The aim of this study was to detect the epidermal growth factor receptor (EGFR) gene type at pre- and postchemotherapy to evaluate the impact of platinum-based chemotherapy on EGFR gene mutations and provide a theoretical foundation for clinical treatment.Around 40 serum DNA samples were collected from advanced nonsmall cell lung cancer patients who received platinum-based chemotherapy as first-line treatment in our hospital from August 1, 2014 to June 1, 2015. 29369176 2018
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 GeneticVariation disease BEFREE Identification of a novel T1151K ALK mutation in a patient with ALK-rearranged NSCLC with prior exposure to crizotinib and ceritinib. 28676215 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE Current clinical guidelines recommend epidermal growth factor receptor (EGFR) mutational testing in patients with metastatic non-small cell lung cancer (NSCLC) to predict the benefit of the tyrosine kinase inhibitor erlotinib as first-line treatment. 28558785 2018
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 Biomarker disease BEFREE Here, we evaluate the efficacy and mechanistic rationale for combining mTOR and WEE1 inhibition as a potential therapy for lung cancers harboring <i>KRAS</i> mutations.<b>Experimental Design:</b> We investigated the synergistic effect of combining mTOR and WEE1 inhibitors on cell viability, apoptosis, and DNA damage repair response using a panel of human <i>KRAS-</i>mutant and wild type NSCLC cell lines and patient-derived xenograft cell lines. 28821559 2018
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 Biomarker disease BEFREE Alectinib Superior to Crizotinib for ALK+ NSCLC. 28600466 2018
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 Biomarker disease BEFREE Sequential Use of Anaplastic Lymphoma Kinase Inhibitors in Japanese Patients With ALK-Rearranged Non-Small-Cell Lung Cancer: A Retrospective Analysis. 28065466 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 GeneticVariation disease BEFREE Prolonged survival of patients with EGFR-mutated non-small cell lung cancer with solitary brain metastases treated with surgical resection of brain and lung lesions followed by EGFR TKIs. 29037198 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 GeneticVariation disease BEFREE Already approved by the US Food and Drug Administration in the narrow context of epidermal growth factor receptor-mutated non-small cell lung cancer, plasma genotyping assays are currently being investigated in a wide array of clinical settings and modalities. 29071812 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 GeneticVariation disease BEFREE Droplet digital PCR improved the EGFR mutation diagnosis with pleural fluid samples in non-small-cell lung cancer patients. 28602964 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 GeneticVariation disease BEFREE Increasing evidence has demonstrated that exon 19 deletions (Del19) and L858R mutation in EGFR have different prognostic and predictive roles in NSCLC. 28576746 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 GeneticVariation disease BEFREE Evaluation of 99mTc-HYNIC-MPG as a novel SPECT radiotracer to detect EGFR-activating mutations in NSCLC. 28489575 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 GeneticVariation disease BEFREE Miliary metastases are associated with epidermal growth factor receptor mutations in non-small cell lung cancer: a population-based study. 28521651 2018
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 GeneticVariation disease BEFREE KRAS G12C mutation as a poor prognostic marker of pemetrexed treatment in non-small cell lung cancer. 28407465 2018
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 Biomarker disease BEFREE Phase 3 study of ceritinib vs chemotherapy in ALK-rearranged NSCLC patients previously treated with chemotherapy and crizotinib (ASCEND-5): Japanese subset. 29474558 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 GeneticVariation disease BEFREE Osimertinib is an oral, central nervous system-active, EGFR tyrosine kinase inhibitor (TKI) for the treatment of EGFR T790M-positive advanced NSCLC. 28527899 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE A phase II trial of carboplatin plus S-1 for elderly patients with advanced non-small-cell lung cancer with wild-type epidermal growth factor receptor: The Okayama Lung Cancer Study Group Trial 1202. 29191594 2018