Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 55193
Gene Symbol: PBRM1
PBRM1
0.400 Biomarker disease BEFREE PBRM1 regulates proliferation and the cell cycle in renal cell carcinoma through a chemokine/chemokine receptor interaction pathway. 28846693 2017
Entrez Id: 55193
Gene Symbol: PBRM1
PBRM1
0.400 GeneticVariation disease BEFREE A germline mutation in PBRM1 predisposes to renal cell carcinoma. 25911086 2016
Entrez Id: 55193
Gene Symbol: PBRM1
PBRM1
0.400 Biomarker disease BEFREE Compared to patients with PBRM1+ BAP1+ tumors those with PBRM1- BAP1+ lesions were more likely to die of renal cell carcinoma (HR 1.39, p = 0.035), followed by those with PBRM1+ BAP1- and PBRM1- BAP1- tumors (HR 3.25 and 5.2, respectively, each p <0.001). 26300218 2016
Entrez Id: 55193
Gene Symbol: PBRM1
PBRM1
0.400 GeneticVariation disease BEFREE Computational analysis of the mutations in BAP1, PBRM1 and SETD2 genes reveals the impaired molecular processes in renal cell carcinoma. 26452128 2016
Entrez Id: 55193
Gene Symbol: PBRM1
PBRM1
0.400 Biomarker disease BEFREE PBRM1 acts as tumor suppressor in RCC, and its downregulation is associated with increased proliferation and aggressive behavior in RCC. 24063284 2014
Entrez Id: 55193
Gene Symbol: PBRM1
PBRM1
0.400 GeneticVariation disease BEFREE The four most commonly mutated genes in RCC of clear-cell type (the most common type) are two-hit tumor suppressor genes, and they cluster in a 43-Mb region on chromosome 3p that is deleted in approximately 90% of tumors: VHL (mutated in ∼80%), PBRM1 (∼50%), BAP1 (∼15%), and SETD2 (∼15%). 23832661 2014
Entrez Id: 55193
Gene Symbol: PBRM1
PBRM1
0.400 Biomarker disease BEFREE PBRM1 and BAP1 as novel targets for renal cell carcinoma. 23867514 2014
Entrez Id: 55193
Gene Symbol: PBRM1
PBRM1
0.400 AlteredExpression disease BEFREE Loss of PBRM1 expression is associated with renal cell carcinoma progression. 22949125 2013
Entrez Id: 55193
Gene Symbol: PBRM1
PBRM1
0.400 Biomarker disease CTD_human Integrated molecular analysis of clear-cell renal cell carcinoma. 23797736 2013
Entrez Id: 55193
Gene Symbol: PBRM1
PBRM1
0.400 Biomarker disease BEFREE Data from RNA interference (RNAi) assays suggest that loss of function of PBRM1 drives proliferation and growth of ccRCC, but the clinical relevance of this is unclear and restoring the function of these genes for therapeutic purposes is likely to be challenging. 22249190 2012
Entrez Id: 55193
Gene Symbol: PBRM1
PBRM1
0.400 GeneticVariation disease BEFREE Notably, mutations in BAP1 and PBRM1 anticorrelate in tumors (P = 3 × 10(-5)), [corrected] and combined loss of BAP1 and PBRM1 in a few RCCs was associated with rhabdoid features (q = 0.0007). 22683710 2012
Entrez Id: 55193
Gene Symbol: PBRM1
PBRM1
0.400 Biomarker disease CTD_human Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. 22138691 2012
Entrez Id: 55193
Gene Symbol: PBRM1
PBRM1
0.400 Biomarker disease BEFREE Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. 21248752 2011