Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE RBCK1 promotes p53 degradation via ubiquitination in renal cell carcinoma. 30874541 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression disease BEFREE Analysis by flow cytometry revealed that RCC cell proliferation inhibitory effect of SSd was achieved by inducing apoptosis and cell cycle arrest at G0/G1 phase via up-regulation of p53. 28485157 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE Long noncoding RNA ATB participates in the development of renal cell carcinoma by downregulating p53 via binding to DNMT1. 30536843 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE Transglutaminase 2 (TGase 2) plays a key role in p53 regulation, depleting p53 tumor suppressor through autophagy in renal cell carcinoma. 30231606 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE In contrast, mutational profiles within the epithelial and sarcomatoid components of sarcomatoid RCC were shown to be identical, with TP53 being the most frequently altered gene. 30934624 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE However, there was no difference in expression of these isoforms between MT p53 RCC tissues and NAT. 30948335 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression disease BEFREE The loss of <i>Tp53</i> and <i>Tsc1</i> within nestin-expressing cells in mice resulted in the development of renal cell carcinomas (RCC) with high <i>Notch1</i> and <i>Nodal</i> expression, suggesting that similar downstream mechanisms contribute to tumorigenesis as a result of p53 loss in mice and p53 polymorphism in humans. 31088907 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression disease BEFREE Recently, we found that the increase of TGase 2 expression is required for p53 depletion in RCC by transporting the TGase 2 (1-139 a.a)-p53 complex to the autophagosome, through TGase 2 (472-687 a.a) binding p62. 30105541 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression disease BEFREE Mass spectrometry analysis revealed that streptonigrin binds to the N-terminus of TGase 2 (amino acids 95⁻116), which is associated with inhibition of TGase 2 activity in vitro and with p53 stabilization in RCC. 30463244 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression disease BEFREE Correction: Prognostic and clinicopathological value of p53 expression in renal cell carcinoma: a meta-analysis. 30555638 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE Recurrent secondary molecular alterations in clear cell RCC (BAP1, SETD2, PBRM1, and TP53) and papillary RCC (CDKN2A) may be associated with poor prognosis; however, intratumoral genomic heterogeneity may limit the clinical utility of these molecular biomarkers in renal mass biopsies. 29708949 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression disease BEFREE Patients diagnosed with RCC in our center were into this study. mRNA expressions of p53 isoforms (p53α, p53β, p53γ) in tumors were determined by RT-PCR and real-time PCR. 29346503 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE Among the 11 non-responders 7 (64%) were wild-type, 2 (18%) were p53 mutated and 2 (18%) VHL1 mutated.No significant associations were found among RCC histotype, mutation variants and response to therapies. 27741505 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression disease BEFREE In in vitro studies, depletion of PARG1by siRNA in human RCC cell lines inhibited their proliferation through inducing G1 cell cycle arrest via upregulation of p53 and subsequent p21<sup>Cip1/Waf1</sup>, which are mediated by increased RhoA-ROCK activities. 28131798 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE Spearman ranking correlation analysis showed that expression of PUMA, MCL-1, and p53 in was negatively correlated with RCC (r = -0.504, P = 0.001; r = -0.413, P = 0.008). 28692117 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression disease BEFREE These findings suggested that CNPY2 promoted cancer cell growth in RCC through regulating TP53 gene expression. 28235487 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE Combined Treatment with CCI779 and SB203580 Induces Cellular Senescence in Renal Cell Carcinoma Cell Line via p53 Pathway. 28270077 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE CAIX, p53 and Bcl-2 might play important roles in the transformation from renal cell carcinoma to high malignant sarcomatoid differentiation, and these three immunohistochemical markers are adverse prognostic factors for the survival of patients with RCC with sarcomatoid differentiation. 28449664 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression disease BEFREE The results showed that p53 positive expression is associated with poor overall survival (OS) (HR = 2.17, 95% confidence [CI]: 1.51-3.13) and cancer-specific survival (CSS) (HR = 1.59, 95% CI: 1.19-2.12) in RCC. 29254251 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE Synergistic roles of p53 and HIF1α in human renal cell carcinoma-cell apoptosis responding to the inhibition of mTOR and MDM2 signaling pathways. 26937175 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE We found that TGase 2 competes with human double minute 2 homolog (HDM2) for binding to p53; promotes autophagy-dependent p53 degradation in renal cell carcinoma (RCC) cell lines under starvation; and binds to p53 and p62 simultaneously without ubiquitin-dependent recognition of p62. 27031960 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE Quantification of tumors cells with TP53 gene alterations showed a significant increase in the metastases compared to the primary RCCs, and, strikingly, the xenografts were similar to the metastases and not to the primary RCCs from which they were derived.Using laser-microdissection of p53-expressing tumor cells, we identified TP53-mutated tumor cells in the xenografts derived from the primary RCC, and in a lung metastasis later developed in one patient. 26002555 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease CTD_human Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes. 25401301 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression disease BEFREE A growing body of evidence also suggests that p53 expression and increased co-expression of MDM2 are linked with poor prognosis in RCC. 25067787 2014