Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2034
Gene Symbol: EPAS1
EPAS1
0.700 Biomarker disease BEFREE HAF mediates the evasive resistance of anti-angiogenesis TKI through disrupting HIF-1α and HIF-2α balance in renal cell carcinoma. 28572533 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 AlteredExpression disease BEFREE Phosphatase and tensin homolog (PTEN) expression on oncologic outcome in renal cell carcinoma: A systematic review and meta-analysis. 28672019 2017
Entrez Id: 2034
Gene Symbol: EPAS1
EPAS1
0.700 GeneticVariation disease GWASCAT Genome-wide association study identifies multiple risk loci for renal cell carcinoma. 28598434 2017
Entrez Id: 2034
Gene Symbol: EPAS1
EPAS1
0.700 GeneticVariation disease BEFREE PHGDH as a Key Enzyme for Serine Biosynthesis in HIF2α-Targeting Therapy for Renal Cell Carcinoma. 28951458 2017
Entrez Id: 2034
Gene Symbol: EPAS1
EPAS1
0.700 Biomarker disease BEFREE Cell culture metabolomics analysis was utilized to determined effect of VHL and HIF-1α or HIF-2α on metabolism of renal cell carcinomas (RCC). 26620126 2016
Entrez Id: 2034
Gene Symbol: EPAS1
EPAS1
0.700 GeneticVariation disease BEFREE Somatic mutations in HIF2A have been reported in PPGLs associated with polycythemia, which have been reported to also be present in patients with RCCs and HBs. 26514359 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE Relevance and therapeutic possibility of PTEN-long in renal cell carcinoma. 25714556 2016
Entrez Id: 2034
Gene Symbol: EPAS1
EPAS1
0.700 Biomarker disease BEFREE HIF2α is involved in the expansion of CXCR4-positive cancer stem-like cells in renal cell carcinoma. 26439684 2016
Entrez Id: 2034
Gene Symbol: EPAS1
EPAS1
0.700 GeneticVariation disease BEFREE The authors observed evidence of interactions between PhIP and RCC susceptibility variants in 2 genes: inositol 1,4,5-trisphosphate receptor, type 2 (ITPR2) (rs718314; multiplicative P for interaction = .03 and additive P for interaction =.002) and endothelial PAS domain-containing protein 1 (EPAS1) (rs7579899; additive P for interaction =.06). 26551148 2016
Entrez Id: 2034
Gene Symbol: EPAS1
EPAS1
0.700 GeneticVariation disease GWASCAT Common variation at 1q24.1 (ALDH9A1) is a potential risk factor for renal cancer. 25826619 2016
Entrez Id: 2034
Gene Symbol: EPAS1
EPAS1
0.700 Biomarker disease BEFREE Herein, we provide mechanistic evidence that HIF-2α can be degraded in cytoplasm under hypoxic conditions via the 26S proteasome and that MDM2 is the E3 ligase which induces the hypoxic degradation of HIF-2α in PI-3K-dependent manner in VHL-deficient RCC cells. 25578041 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease CTD_human Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes. 25401301 2015
Entrez Id: 2034
Gene Symbol: EPAS1
EPAS1
0.700 Biomarker disease BEFREE Our data provide insight into the link between HIF2α, the ITPR1-related pathway, and natural immunity and strongly suggest a role for the HIF2α/ITPR1 axis in regulating RCC cell survival. 25297632 2015
Entrez Id: 2034
Gene Symbol: EPAS1
EPAS1
0.700 AlteredExpression disease BEFREE Furthermore, we demonstrate that peroxisome abundance is reduced in VHL-deficient human clear cell renal cell carcinomas with high HIF-2α levels. 25440060 2015
Entrez Id: 2034
Gene Symbol: EPAS1
EPAS1
0.700 AlteredExpression disease BEFREE Restricted expression of miR-30c-2-3p and miR-30a-3p in clear cell renal cell carcinomas enhances HIF2α activity. 24189146 2014
Entrez Id: 2034
Gene Symbol: EPAS1
EPAS1
0.700 Biomarker disease BEFREE Notably, NOX4 silencing or superoxide scavenging was sufficient to block nuclear accumulation of HIF2α in RCC cells. 24755467 2014
Entrez Id: 2034
Gene Symbol: EPAS1
EPAS1
0.700 AlteredExpression disease BEFREE We find that DDT expression mirrors MIF expression in ccRCC tumor sections with high correlation and that, mechanistically, DDT is a novel hypoxia-inducible gene and direct target of HIF1α and HIF2α. 24356968 2014
Entrez Id: 2034
Gene Symbol: EPAS1
EPAS1
0.700 Biomarker disease BEFREE To investigate the oncolytic efficacy of a highly virulent (velogenic) Newcastle disease virus (NDV) in the presence or absence of HIF-2α, renal cell carcinoma (RCC) cell lines with defective or reconstituted wild-type (wt) von Hippel-Lindau (VHL) activity were used. 23506478 2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE Because loss of PTEN can activate mTOR and mTOR inhibitors are Food and Drug Administration approved to treat renal cell carcinoma, these agents have clinical potential in renal cell carcinoma associated with Cowden syndrome. 23764071 2014
Entrez Id: 2034
Gene Symbol: EPAS1
EPAS1
0.700 AlteredExpression disease BEFREE Proteomic analysis of signaling network regulation in renal cell carcinomas with differential hypoxia-inducible factor-2α expression. 23940778 2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE Another variant (rs701848) in the 3'UTR region of PTEN was associated with increased RCC risk (P = 0.014, OR = 1.45, 95%CI = 1.08-1.96, CC vs. TT); however, the association was not significant after adjusting for multiple comparisons. 23209702 2013
Entrez Id: 2034
Gene Symbol: EPAS1
EPAS1
0.700 Biomarker disease BEFREE HIF-2α is stabilized in von Hippel-Lindau (VHL)-deficient renal cell carcinoma through mechanisms that require ongoing mRNA translation. 22869144 2013
Entrez Id: 2034
Gene Symbol: EPAS1
EPAS1
0.700 GeneticVariation disease BEFREE In follow-up of a recent genome-wide association study (GWAS) that identified a locus in chromosome 2p21 associated with risk for renal cell carcinoma (RCC), we conducted a fine mapping analysis of a 120 kb region that includes EPAS1. 22113997 2012
Entrez Id: 2034
Gene Symbol: EPAS1
EPAS1
0.700 GeneticVariation disease GWASDB A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23. 22010048 2012