Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 Biomarker disease BEFREE GSTM1 exhibited a significant association with increased risk of squamous cell carcinoma (p < 0.001). 25663492 2015
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 GeneticVariation disease BEFREE Subgroup analysis showed a significant relationship between squamous carcinoma (SC), adenocarcinoma (AC) or small cell lung carcinoma (SCLC) and GSTM1 null genotype, as well as SC or AC and GSTT1 null genotype. 25036724 2014
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 GeneticVariation disease BEFREE Glutathione S-transferase M1 (GSTM1) null genotype may be a candidate genetic polymorphism with a role in susceptibility to skin cancer such as basal and squamous cell carcinomas. 23184764 2013
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 GeneticVariation disease BEFREE GSTT1, GSTM1, GSTP1 polymorphism did not show any significant association with SCC. 22248273 2012
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 Biomarker disease CTD_human Moreover, a significant increase in the risk to SCC of lung in the cases carrying combination of variant genotype of CYP1A2 with either CYP1A1 or GSTM1 have shown that gene-gene interactions may play an important role in squamous cell lung cancer risk. 22072123 2012
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 GeneticVariation disease BEFREE Moreover, a significant increase in the risk to SCC of lung in the cases carrying combination of variant genotype of CYP1A2 with either CYP1A1 or GSTM1 have shown that gene-gene interactions may play an important role in squamous cell lung cancer risk. 22072123 2012
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 GeneticVariation disease BEFREE The frequency of one null genotype of the GSTM1 or GSTT1 gene was higher in patients with pharyngeal SCC and heavy smoking status than in controls (76.3% versus 57.7%, P = 0.04). 21870186 2011
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 GeneticVariation disease BEFREE The genotype for GSTM1 (mutation vs. wild type) was determined by polymerase chain reaction (PCR) using genomic DNA extracted from peripheral blood from 28 OSCC patients. 20060357 2010
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 GeneticVariation disease BEFREE The combined 'at risk' genotypes of GSTM1 null and GSTT1 null in comparison with 'wild-type' genotypes seems to be associated with a greater risk of lung cancer, but the results are not significant (odds ratio (OR) 2.0, 95% confidence interval (CI) 0.68-5.96) and for squamous cell carcinoma (SqCC) it was 1.6-fold (OR 1.6, 95% CI 0.49-5.68). 18415801 2008
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 GeneticVariation disease LHGDN GSTM1 and GSTT1 null genotype frequencies were evaluated by multiplex PCR in 45 cigarette smokers with head and neck squamous cell carcinomas and 45 cigarette smokers without this disease. 17221058 2007
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 GeneticVariation disease LHGDN Polymorphisms of CYP1A1 and GSTM1 genes and susceptibility to oral cancer. 17461521 2007
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 GeneticVariation disease BEFREE In this study we were unable to show a correlation between GSTM1 and GSTT1 genotypes and the development of head and neck squamous cell carcinomas in cigarette smokers. 17221058 2007
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 GeneticVariation disease BEFREE GSTM1 polymorphisms seem to be involved in BCC risk, while GSTM1 null/null genotype combined with CYP1A1 allele Val(462) are associated with a higher risk for SCC, indicating that allelism and/or interactions between allelic variants at other loci may also influence the risk of NMSC, particularly SCC. 17083362 2006
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 GeneticVariation disease BEFREE In agreement with some literature data, our results support the concerted role of CYP1A1 and GSTM1 at-risk genotypes in SCC predisposition. 16416283 2006
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 GeneticVariation disease BEFREE The purpose of this study was to evaluate the prognostic ability of polymorphisms of three genes involved in the metabolism of tobacco carcinogens (GSTT1, GSTM1, GSTP1) and one polymorphism of a DNA repair gene (XRCC1) for patients diagnosed with squamous cell carcinoma (SCC). 15668931 2005
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 GeneticVariation disease BEFREE Accumulation of certain alleles or genotypes of the CYP1A1, NAT2, GSTM1 and XPD seems to be associated with either increased or decreased risk to develop laryngeal SCC. 15914211 2005
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 GeneticVariation disease LHGDN Association of GST genotypes with age of onset and lymph node metastasis in oral squamous cell carcinoma. 16091114 2005
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 AlteredExpression disease LHGDN GSTM1*2/*2 and CYP1A1*1A/*2C genotype frequencies were higher among squamous cell carcinomas at a level close to statistical significance (OR = 1.83, 95% CI 0.88-3.83, P = 0.11; OR = 3.03, 95% CI 0.93-9.90, P = 0.07, respectively). 15526353 2004
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 GeneticVariation disease BEFREE GSTM1 polymorphism and oral squamous cell carcinoma. 14662415 2004
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 GeneticVariation disease LHGDN Gene polymorphisms in detoxification enzymes as susceptibility factor for head and neck cancer? 12748560 2003
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 GeneticVariation disease BEFREE The GSTM1 null genotype was associated with a decreased risk of squamous cell carcinoma: the OR, adjusted for age, sex and pack years was 0.32 (95% CI 0.12-0.82). 12175548 2002
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 GeneticVariation disease BEFREE Among AC and SCC cancer patients, individuals with the GSTM1-null genotype had an OR of 1.80 (95% CI, 1.1-2.8; case-only analysis) of having AC versus SCC if they also carried a p53 Pro allele. 11751390 2001
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 AlteredExpression disease BEFREE While adjusted odds ratios (ORs) indicated no significantly increased risk for lung cancer overall due to any single GST genotype, the risk alleles for GSTM1, GSTM3 and GSTP1 conferring reduced enzyme activity were present at higher frequency in SCC than in AC patients. 11740339 2001
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 Biomarker disease BEFREE Analysis of the interaction between GSTM1 null and sunbathing score showed that the two factors were synergistic and individuals with both risk parameters demonstrated a shorter time from transplantation to development of the first SCC (p = 0.012, hazard ratio = 7.1). 11511301 2001
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 Biomarker disease BEFREE Individuals with a combined genotype of Val/Val and GSTM1(-) were at an increased risk for oral SCC compared with other combined genotypes, in particular, at a low dose level of cigarette smoking. 10793329 2000