Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 GeneticVariation disease BEFREE KRAS mutations were preferentially detected in patients with adenocarcinomas, and the frequency of PIK3CA mutations in patients with squamous cell carcinomas was higher than that in patients with other histological cancer types. 31757465 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE Erratum: Adenosine induces intrinsic apoptosis via the PI3K/Akt/mTOR signaling pathway in human pharyngeal squamous carcinoma FaDu cells. 30867805 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression disease BEFREE TROP2 increases growth and metastasis of human oral squamous cell carcinoma through activation of the PI3K/Akt signaling pathway. 31638186 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE <i>PAR-2</i> promotes cell proliferation, migration, and invasion through activating PI3K/AKT signaling pathway in oral squamous cell carcinoma. 31213575 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 GeneticVariation disease BEFREE Transformed SCC acquired genomic alterations related to the PI3K/AKT/mTOR pathway, in addition to the initial EGFR mutation. 31319998 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE Increased LGALS3BP promotes proliferation and migration of oral squamous cell carcinoma via PI3K/AKT pathway. 31302247 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE PI3K inhibitors such as PI-103, PI-828 and PX-866 may be developed as potential therapeutic agents for effective treatment of oral squamous cell carcinoma (OSCC) patients, associated with activated PI3K/Akt pathway. 30519710 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE The immunoregulatory protein B7-H3 promotes aerobic glycolysis in oral squamous carcinoma via PI3K/Akt/mTOR pathway. 31737114 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE Astaxanthin inhibits hallmarks of cancer by targeting the PI3K/NF-κΒ/STAT3 signalling axis in oral squamous cell carcinoma models. 31251469 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 GeneticVariation disease BEFREE This may be because pathways enriched in the TrkB high expressers, like those involving oncogenes NFE2L2, PIK3CA, and SOX2, are known to have SCC anatomic site-specific effects on progression. 31221127 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE Our data suggest that the PI3K/AKT pathway is related to cell survival and proliferation in oral squamous cell carcinoma through its interaction with Bcl-2 family members.<br />. 31759362 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE Licochalcone A inhibits cell proliferation, migration, and invasion through regulating the PI3K/AKT signaling pathway in oral squamous cell carcinoma. 31239711 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE Integrin-α5 promoted the progression of oral squamous cell carcinoma and modulated PI3K/AKT signaling pathway. 30909080 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE Adenosine induces intrinsic apoptosis via the PI3K/Akt/mTOR signaling pathway in human pharyngeal squamous carcinoma FaDu cells. 29616118 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE KRAS and EGFR mutations were significantly more frequent in adenocarcinomas: PIK3CA in squamous cell carcinomas. 29186353 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression disease BEFREE The PI3K/AKT/mTOR pathway is frequently activated in various squamous cell carcinomas (SCCs). 30568499 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE PIK3CA gene copy number increase is associated with a favorable clinical outcome in HPV-negative OPCs treated with surgery ± postoperative radiotherapy. 29714670 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression disease BEFREE mTORis do not significantly change the immunohistochemical expression of molecules upstream of the mTOR inhibition (pmTOR, PI3K, pAkt), in cutaneous SCC. 29848679 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 GeneticVariation disease BEFREE Using samples from 122 patients, we established 41 NSCLC PDXs [30 adenocarcinoma (AD), 11 squamous cell carcinoma (SQ)], among which the following driver mutation were observed: 13 EGFR-mutant, 4 ALK-rearrangement, 1 ROS1-rearrangement, 1 PIK3CA-mutant, 1 FGFR1-amplification, and 2 KRAS-mutant. 30268457 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE Computational analysis indicated that miR-296-3p targeted PTEN, which regulates the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway and PTEN is involved in the carcinogenesis of SCC. miR-296-3p directly regulated PTEN expression in head and neck cancer cells, with PTEN protein levels decreased in 4/19 the SCCs (21.0%), as compared with those in the IPs (76.4%). 28693263 2017
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 GeneticVariation disease BEFREE Whether they function as direct precursors to a less common form of squamous cell carcinoma will require further study, but carcinomas associated with these lesions might warrant testing for PIK3CA mutations to address this question. 27834349 2017
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE Paraoxonase 3 promotes cell proliferation and metastasis by PI3K/Akt in oral squamous cell carcinoma. 27923688 2017
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE The activated pathway in lung ADC and SCC mainly focuses on MAPK and PI3K with different key genes of each, respectively, and the activated pathway of SCLC mainly focuses on JAK-STAT pathway. 27845189 2017
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 GeneticVariation disease BEFREE We have studied the prognostic importance of PIK3CA mutations as well as the relation to other markers in a large number of early stage lung cancers of squamous carcinoma subtype. 28024696 2017
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE These findings offer a novel strategy that could potentially enhance the efficacy of PI3Kα inhibitors while mitigating dose-limiting toxicity in patients with head and neck squamous cell carcinomas. 28194032 2017