Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE Immunohistochemical assessment of growth factor signaling molecules: MAPK, Akt, and STAT3 pathways in oral epithelial precursor lesions and squamous cell carcinoma. 31062130 2020
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 AlteredExpression disease BEFREE STAT3-induced upregulation of long noncoding RNA HNF1A-AS1 promotes the progression of oral squamous cell carcinoma via activating Notch signaling pathway. 30404566 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE Anti-proliferative effect of 8α-tigloyloxyhirsutinolide-13-O-acetate (8αTGH) isolated from Vernonia cinerea on oral squamous cell carcinoma through inhibition of STAT3 and STAT2 phosphorylation. 30599904 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE CD133 receptor mediated delivery of STAT3 inhibitor for simultaneous elimination of cancer cells and cancer stem cells in oral squamous cell carcinoma. 31371076 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE STAT3- and GSK3β-mediated Mcl-1 regulation modulates TPF resistance in oral squamous cell carcinoma. 30395230 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 AlteredExpression disease BEFREE Moreover, increased PCBP1 inhibited the growth of oral squamous cell carcinoma and breast cancer cells, and the expression of STAT3 target genes. 31223278 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE Abnormal activation of signal transducer and activator of transcription 3 (STAT3) serves a pivotal role in oral squamous cell carcinoma (OSCC) tumor cell invasion into normal tissues or distant organs. 29532870 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE 2-O-Methylmagnolol Induces Apoptosis and Inhibits IL-6/STAT3 Signaling in Oral Squamous Cell Carcinoma. 30355952 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 GeneticVariation disease BEFREE The OE33 (OAC) and OE21 (SCC) cell lines were treated with the STAT3 inhibitor, STATTIC. 29890775 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 AlteredExpression disease BEFREE Results from the patients' samples showed that the Phospho-STAT3 has a significant association with cyclin D1 overexpression in OSCC tumor samples. 29516928 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 AlteredExpression disease BEFREE We found a negative correlation between the expression of hsa-miR-21 expression and STAT3 in oral squamous cell carcinoma. 29976158 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE Clinical Roles of Interleukin-6 and STAT3 in Oral Squamous Cell Carcinoma. 27744625 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE STAT3 regulates hypoxia-induced epithelial mesenchymal transition in oesophageal squamous cell cancer. 27220595 2016
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE STAT3 nuclear translocation was more frequent in adenocarcinomas and squamous cell carcinomas than that of their noncancerous counterparts. 26432044 2015
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease CTD_human STAT3 nuclear translocation was more frequent in adenocarcinomas and squamous cell carcinomas than that of their noncancerous counterparts. 26432044 2015
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 AlteredExpression disease BEFREE Protein inhibitor of activated signal transducer and activator of transcription 3 (STAT3) (PIAS3) is an endogenous inhibitor of STAT3 that negatively regulates STAT3 transcriptional activity and cell growth and demonstrates limited expression in the majority of human squamous cell carcinomas of the lung. 23959540 2014
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 AlteredExpression disease BEFREE STAT3 expression, activity and functional consequences of STAT3 inhibition in esophageal squamous cell carcinomas and Barrett's adenocarcinomas. 23912451 2014
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 AlteredExpression disease BEFREE Here we show a clear correlation between the efficacy of anti-EGFR inhibitors with their ability to inhibit STAT3 activity in A431 epidermoid carcinoma cells and in a series of wt K-RAS expressing human colon cancer cell lines. 24556630 2014
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE STAT3 oligonucleotide inhibits tumor angiogenesis in preclinical models of squamous cell carcinoma. 24404126 2014
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE Intercellular contact augments epidermal growth factor receptor (EGFR) and signal transducer and activator of transcription 3 (STAT3)-activation which increases podoplanin-expression in order to promote squamous cell carcinoma motility. 23266472 2013
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 AlteredExpression disease BEFREE Moreover, the differences in STAT3 gene expression between squamous cell carcinoma and large cell carcinoma histopathological subtypes were observed. 24382554 2013
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 AlteredExpression disease BEFREE These findings indicate that basal stem/progenitor cells are the cells of origin of squamous carcinoma and that cooperation between Sox2 and microenvironment-activated Stat3 is required for Sox2-driven tumorigenesis. 23472872 2013
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE Together, our findings provide evidence that ΔNp63α expression is regulated by EGFR activation through STAT3 and that the EGFR-ΔNp63α axis is crucial for proliferation of TICs present in SCCs. 23018838 2013
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 AlteredExpression disease BEFREE STAT5A-mediated SOCS2 expression regulates Jak2 and STAT3 activity following c-Src inhibition in head and neck squamous carcinoma. 22090359 2012
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE Our results suggest that Stat3 is involved in the motility, metastasis and progression in human lingual squamous cell carcinoma, and thus, it may be a therapeutic target for human lingual squamous cell carcinoma. 22302289 2012