Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8626
Gene Symbol: TP63
TP63
0.400 AlteredExpression disease BEFREE Once a broad tumor class is established, more specific differentiation markers can be pursued (e.g., lineage-restricted transcription factors for adenocarcinoma; p40 for squamous cell carcinoma; chromogranin A and synaptophysin or INSM1 for neuroendocrine neoplasms). 31786484 2020
Entrez Id: 8626
Gene Symbol: TP63
TP63
0.400 Biomarker disease BEFREE The SSP was developed in 68 NSCLC tumors of adenocarcinoma (AC), squamous cell carcinoma (SqCC) and large-cell neuroendocrine carcinoma (LCNEC) histology, based on NanoString expression of 11 (CHGA, SYP, CD56, SFTPG, NAPSA, TTF-1, TP73L, KRT6A, KRT5, KRT40, KRT16) relevant genes for IHC-based NSCLC histology classification. 30914778 2019
Entrez Id: 8626
Gene Symbol: TP63
TP63
0.400 Biomarker disease BEFREE In order to check the assumption that p63 is a useful marker for squamous cellular differentiation, we used two antibodies: anti-p63 and anti-thyroid transcription factor-1 (TTF-1), based on their immunoexpression to differentiate small cell lung carcinoma (SCLC) from poorly differentiated nonkeratinizing squamous cell carcinoma (SCC). 31263838 2019
Entrez Id: 8626
Gene Symbol: TP63
TP63
0.400 Biomarker disease BEFREE Although P40 staining for the sarcomatous component was positive along with squamous carcinoma, E-cadherin expression disappeared while vimentin was expressed. 31366562 2019
Entrez Id: 8626
Gene Symbol: TP63
TP63
0.400 Biomarker disease BEFREE As there are few data from South Africa, we aimed to determine utility of TTF-1, napsin A, p63 and CK5 immunostaining on fine needle aspiration (FNA) cell block and formalin-fixed paraffin-embedded tissue biopsy specimens in subtyping NSCLC as adenocarcinoma and squamous cell carcinomas. 31206846 2019
Entrez Id: 8626
Gene Symbol: TP63
TP63
0.400 AlteredExpression disease BEFREE In this study we demonstrate that TP63 directly regulates NRG1 expression in human SCC cell lines and that NRG1 is a critical component of the TP63 transcriptional program. 31144617 2019
Entrez Id: 8626
Gene Symbol: TP63
TP63
0.400 Biomarker disease BEFREE Proteins associated with regulation of the sonic hedgehog pathway, and the Nfe2l2 response, Tp63, and Keap1 and p62/SQSTM1 proteins, showed differential expression in larynx, oral and lung high TrkB1-T1 expresser SCCs. 31221127 2019
Entrez Id: 8626
Gene Symbol: TP63
TP63
0.400 Biomarker disease BEFREE ZNF185 is a p63 target gene critical for epidermal differentiation and squamous cell carcinoma development. 30337687 2019
Entrez Id: 8626
Gene Symbol: TP63
TP63
0.400 Biomarker disease BEFREE Sensitivity of CK5/6, p40, and p63 for SqCC was 93%, 94%, and 94% and specificity was 98%, 97%, and 84%, respectively. 30798982 2019
Entrez Id: 8626
Gene Symbol: TP63
TP63
0.400 Biomarker disease BEFREE Both lesions were squamous cell carcinoma and positive for p40. 31845086 2019
Entrez Id: 8626
Gene Symbol: TP63
TP63
0.400 AlteredExpression disease BEFREE D2-40 and P63 expression highlighted both PAC and SCC and seems to be useful in excluding metastatic BrCa with a sensitivity and specificity of 58% and 100%, and 98% and 100%, respectively. 29781860 2018
Entrez Id: 8626
Gene Symbol: TP63
TP63
0.400 Biomarker disease BEFREE Cytokeratin 5/6 (CK5/6), p63, and p40 are commonly used as immunohistochemical markers for squamous cell carcinoma (SqCC) of the lung. 30546464 2018
Entrez Id: 8626
Gene Symbol: TP63
TP63
0.400 Biomarker disease BEFREE ROCK-dependent phosphorylation of NUP62 regulates p63 nuclear transport and squamous cell carcinoma proliferation. 29217659 2018
Entrez Id: 8626
Gene Symbol: TP63
TP63
0.400 Biomarker disease BEFREE Super-Enhancer-Driven Long Non-Coding RNA LINC01503, Regulated by TP63, Is Over-Expressed and Oncogenic in Squamous Cell Carcinoma. 29454790 2018
Entrez Id: 8626
Gene Symbol: TP63
TP63
0.400 Biomarker disease BEFREE Here, epigenomic profilings of different types of SCCs reveal that TP63 and SOX2 cooperatively and lineage-specifically regulate long non-coding RNA (lncRNA) CCAT1 expression, through activation of its super-enhancers and promoter. 30190462 2018
Entrez Id: 8626
Gene Symbol: TP63
TP63
0.400 Biomarker disease BEFREE As tumor cells showed positive immunostaining for p40 and CK5/6, the immunophenotype of the tumor was consistent with squamous cell carcinoma (SCC). 30216599 2018
Entrez Id: 8626
Gene Symbol: TP63
TP63
0.400 Biomarker disease BEFREE We further define the interactions of keratinocyte PKK with TP63 and NF-κB signaling, highlighting the importance of this protein as a tumor suppressor in SCC development. 29186361 2018
Entrez Id: 8626
Gene Symbol: TP63
TP63
0.400 Biomarker disease BEFREE For differential diagnosis, immunostaining markers such as CK5/6 and p63 can be used to distinguish SCC and CK7 for adenocarcinoma. 27889037 2017
Entrez Id: 8626
Gene Symbol: TP63
TP63
0.400 Biomarker disease BEFREE Immunohistochemistry assay confirmed the positive expression of CK5/6 and p63 in pancreatic SCC. 28099906 2017
Entrez Id: 8626
Gene Symbol: TP63
TP63
0.400 Biomarker disease BEFREE Ber EP4 and MOC 31 immunostains were positive in most cases when performed, and the most specific immunostains for SCC were p63 and p40.Negative mucin stains were helpful. 29024544 2017
Entrez Id: 8626
Gene Symbol: TP63
TP63
0.400 Biomarker disease BEFREE The sensitivities of p40, p63 and cytokeratin 5/6 were 100% with specificities of 88%, 46% and 81%, respectively, for SCC. 29187465 2017
Entrez Id: 8626
Gene Symbol: TP63
TP63
0.400 Biomarker disease BEFREE CD44 and p63 are identified as candidate stem cell markers in normal squamous epithelium and SCC. 28645102 2017
Entrez Id: 8626
Gene Symbol: TP63
TP63
0.400 AlteredExpression disease BEFREE The higher protein level of p63 in SCC was attenuated by the transfection of PKC-δ. 28756980 2017
Entrez Id: 8626
Gene Symbol: TP63
TP63
0.400 Biomarker disease BEFREE We characterized captured cells using TTF1 and p40 as immunostaining biomarkers of adenocarcinoma and squamous cell carcinoma, respectively. 28298147 2017
Entrez Id: 8626
Gene Symbol: TP63
TP63
0.400 Biomarker disease BEFREE ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis. 28041841 2017