Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.400 GeneticVariation disease BEFREE TP53, NOTCH1, CASP8, CDKN2A, and CDH1 are the most frequently mutated genes in OSCC patients. 30041611 2018
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.400 AlteredExpression disease BEFREE We observed that CDH1 methylation is significantly correlated with decreased CDH1 protein expression in eyelid SCC patients. 26790440 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.400 Biomarker disease BEFREE We show that the loss of both Cdh1 and Tgfbr2 in both models is sufficient to induce squamous cell carcinomas with animals succumbing to the invasive disease by 18 months of age. 25233932 2014
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.400 PosttranslationalModification disease BEFREE Quantitative methylation-specific PCR analysis showed a significant increase in promoter hypermethylation of p16 and CDH1 in OSCC tumors relative to paired non-tumorous tissues. 20729138 2010
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.400 PosttranslationalModification disease LHGDN Promoter methylation of TIMP3 and CDH1 predicts better outcome in head and neck squamous cell carcinoma treated by radiotherapy only. 19148529 2009
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.400 GeneticVariation disease LHGDN Association of CDH1 single nucleotide polymorphisms with susceptibility to esophageal squamous cell carcinomas and gastric cardia carcinomas. 18197935 2008
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.400 GeneticVariation disease BEFREE Association of CDH1 single nucleotide polymorphisms with susceptibility to esophageal squamous cell carcinomas and gastric cardia carcinomas. 18197935 2008
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.400 PosttranslationalModification disease LHGDN CpG island hypermethylation of E-cadherin (CDH1) and integrin alpha4 is associated with recurrence of early stage esophageal squamous cell carcinoma. 18697202 2008
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.400 Biomarker disease LHGDN Relationship between decreased expression of squamous cell carcinoma antigen 2 and E-cadherin in primary cervical cancer lesions and lymph node metastasis. 18097581 2008
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.400 Biomarker disease LHGDN Epithelial to mesenchymal transition in head and neck squamous carcinoma: association of Src activation with E-cadherin down-regulation, vimentin expression, and aggressive tumor features. 18327819 2008
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.400 AlteredExpression disease LHGDN The study of E-cadherine and CD44 immunoexpression in oral squamous cell carcinoma. 18516325 2008
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.400 Biomarker disease CTD_human Promoter methylation as a common mechanism for inactivating E-cadherin in human salivary gland adenoid cystic carcinoma. 17520682 2007
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.400 AlteredExpression disease LHGDN Induction of alpha2-antiplasmin inhibits E-cadherin processing mediated by the plasminogen activator/plasmin system, leading to suppression of progression of oral squamous cell carcinoma via upregulation of cell-cell adhesion. 17203182 2007
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.400 AlteredExpression disease LHGDN Altered E-cadherin expression and p120 catenin localization in esophageal squamous cell carcinoma. 17647062 2007
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.400 Biomarker disease LHGDN Loss of intercellular adhesion activates a transition from low- to high-grade human squamous cell carcinoma. 16152579 2006
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.400 Biomarker disease LHGDN Role and expression patterns of E-cadherin in head and neck squamous cell carcinoma (HNSCC). 16761612 2006
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.400 Biomarker disease LHGDN Microsatellite analysis of the APC gene and immunoexpression of E-cadherin, catenin, and tubulin in esophageal squamous cell carcinoma. 16426911 2006
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.400 Biomarker disease BEFREE Our findings indicate that the promoter hypermethylation of cancer-related genes, especially CDH1, is frequently shown in SCCs, and dysregulation of the RB1/p16 and/or p53 pathway through either genetic or epigenetic mechanisms, except for epigenetic abnormalities of p53 itself, should contribute to the carcinogenesis of SCCs. 17034532 2006
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.400 Biomarker disease LHGDN E-cadherin is a selective and strongly dominant prognostic factor in squamous cell carcinoma: a comparison of E-cadherin with desmosomal components. 15609307 2005
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.400 Biomarker disease BEFREE Twenty-two laryngeal squamous cell carcinomas were analyzed in our study regarding genetic changes of two tumor suppressor genes: Adenomatous polyposis coli (APC) and E-cadherin (CDH1). 16259108 2005
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.400 AlteredExpression disease LHGDN Invasion and metastasis of oral cancer cells require methylation of E-cadherin and/or degradation of membranous beta-catenin. 15328184 2004
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.400 AlteredExpression disease BEFREE Thus, methylation of the 5' CpG island in the E-cadherin promoter induces reciprocal expression of E- and N-cadherins in oral SCC by an unknown mechanism that appears to be mediated at the level of N-cadherin gene expression. 14985090 2004
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.400 AlteredExpression disease LHGDN Predictive markers for late cervical metastasis in stage I and II invasive squamous cell carcinoma of the oral tongue. 14734465 2004
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.400 PosttranslationalModification disease BEFREE Promoter hypermethylation of the E-cadherin gene was detected in 6 of 7 cases (85%) of invasive squamous cell carcinoma, 4 of 8 cases (50%) of squamous cell carcinoma in situ, 4 of 9 cases (44%) of actinic keratosis, and 2 of 9 cases (22%) of nonneoplastic skin. 14559984 2003
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.400 AlteredExpression disease LHGDN Expression of e-cadherin and beta-catenin in human esophageal squamous cell carcinoma: relationships with prognosis. 12532436 2003