Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 Biomarker disease BEFREE High-risk human papillomavirus (HPV)-related oropharyngeal squamous cell carcinomas have a more favorable prognosis than HPV-negative ones. p16 immunohistochemistry has been recommended as a prognostic test in clinical practice. 28621317 2018
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 AlteredExpression disease BEFREE To evaluate the impact of HPV16 load (VL-the number of virus genome copies per cell) and P16 expression on prognosis of patients with squamous cell carcinomas (SCCs) of head and neck (HN). 29043437 2018
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 AlteredExpression disease BEFREE Comparative study of p16 protein expression in squamous cell carcinomas from patients with epidermodysplasia verruciformis and patients without the disease. 28439661 2018
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 AlteredExpression disease BEFREE Role of CDKN2A/p16 expression in the prognostication of oral squamous cell carcinoma. 28939073 2018
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.700 GeneticVariation disease BEFREE Association of the XPD and XRCC3 gene polymorphisms with oral squamous cell carcinoma in a Northeastern Brazilian population: A pilot study. 26742000 2017
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 Biomarker disease BEFREE Laser capture microdissection-polymerase chain reaction (LCM-PCR) supported by p16 was used for the first time to demonstrate human papillomavirus (HPV) DNA in histologically specific penile lesions, which were as follows: squamous hyperplasia (12 lesions, 10 patients), flat lesions (12 lesions, 5 patients), condylomas (26 lesions, 7 patients), penile intraepithelial neoplasia (PeIN) (115 lesions, 43 patients), and invasive squamous cell carcinomas (26 lesions, 26 patients). 28486384 2017
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 AlteredExpression disease BEFREE Here we demonstrate that p16(INK4a) overexpression in two cancer cell lines (UAB-3 and UAB-4), derived from oral cavity squamous cell carcinomas with the most aggressive invasive phenotype (worst pattern of invasion type 5 (WPOI-5)), dramatically decreases tumor invasiveness by altering expression of extracellular matrix remodeling genes. 25523612 2016
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 AlteredExpression disease BEFREE Both expression of p16(INK4a) and presence of HR-HPV DNA, but not histologic grade, were inversely associated with pSCC tumour invasion (p = 0.01, p = 0.03, and p = 0.71). 25885064 2016
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 Biomarker disease BEFREE By comparing NGS results of our SCC cohort to a non-SCC cohort (N = 277), we found that CDKN2A, SOX2, NOTCH1, TP53, PIK3CA, CCND1, and FBXW7 were significantly more frequently altered, unlike KRAS, which was less frequently altered in SCC specimens (all P < 0.05; multivariable analysis). 26030731 2016
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 Biomarker disease BEFREE We analyzed 209 samples of head and neck SCC to establish a predictive cutoff for p16 and determine the role of p16 positivity in OTs versus non-OTs. 26481441 2016
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 Biomarker disease BEFREE The loss of heterozygosity (LOH) of markers on 9p21 (D9s1747, RPS6, D9s162) and 17p13 (TP53) and the immunostaining results of the corresponding mutant P53, P14, P15, and P16 proteins were assessed and correlated with LR and disease-free survival in 71 OSCC patients who had HNM. 26260282 2016
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 AlteredExpression disease BEFREE Correlation of p16 expression and HPV type with survival in oropharyngeal squamous cell cancer. 26183400 2016
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.700 Biomarker disease BEFREE For ERCC2 Gln751Gln, the association was significant for both SCCs (P=0.001, OR=10.1, 95% CI=2.6-37.9) and SILs (P=0.001, OR=8.9, 95% CI=2.8-28.3). 25812040 2016
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.700 GeneticVariation disease BEFREE Polymorphisms in ERCC2/XPD Asp312Asn may be associated with increased DNA adduct levels in the lung, especially among subjects with SQCC. 26001533 2016
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 Biomarker disease BEFREE Our results showed two hypomethylated genes (CDKN2A and MGMT) and three hypermethylated genes (CDH13, RUNX3 and APC) in ACs compared with SCCs. 26862903 2016
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 GeneticVariation disease BEFREE Finally, we observed that the expression signatures indentified in phenotypically normal cells carrying CDKN2A mutations or MC1R variants are maintained in skin cancer tumors (melanoma and squamous cell carcinoma). 24742402 2015
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 GeneticVariation disease BEFREE The p14 promoter was unmethylated in 86.7 % of OSCC and in 85.7 % of LSCC patients; for the p16 promoter these rates were 69.0 % and 76.2 % for OSCC and LSCC patients, respectively. 24710824 2015
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 AlteredExpression disease BEFREE HPV-16 or -18 were present in 59.7% (80/134) of abnormal specimens. p16 and E6 mRNA expression was increasing with severity of cervical dysplasia. p16 mRNA expression was found 4.35-fold and 13.15-fold increased in high-grade squamous intraepithelial lesions and squamous cell carcinomas, respectively. 24477172 2015
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 GeneticVariation disease BEFREE Human papillomavirus (HPV), p16 expression, and TP53 mutations are known prognostic factors in head and neck squamous cell carcinoma, but their role in squamous cell carcinoma of the anal canal (SCCAC) is less well established. 25871546 2015
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 Biomarker disease BEFREE HPV infection appears to be involved in cancer progression in SQC by promoting the expression of p53; however, p16 cannot be used as a surrogate marker for HPV infection in SQC. 25544708 2015
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 GeneticVariation disease BEFREE P16(INK⁴a) overexpression is associated with CDKN2A mutation and worse prognosis in HPV-negative laryngeal squamous cell carcinomas. 25652585 2015
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 GeneticVariation disease BEFREE No evidence of oncogenic KRAS mutations in squamous cell carcinomas of the anogenital tract and head and neck region independent of human papillomavirus and p16(INK4a) status. 25257576 2015
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 AlteredExpression disease BEFREE Promoter region hypermethylation and mRNA expression of MGMT and p16 genes in tissue and blood samples of human premalignant oral lesions and oral squamous cell carcinoma. 24991542 2015
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 AlteredExpression disease BEFREE The expression levels of some of these genes including matrix metallopeptidase 1 (MMP1), matrix metallopeptidase 10 (MMP10), parathyroid hormone-like hormone (PTHLH), cyclin-dependent kinase inhibitor 2A (CDKN2A), A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1), FBJ osteosarcoma oncogene (FOS), interleukin 6 (IL6) and reversion-inducing-cysteine-rich protein with kazal motifs (RECK) were significantly differentially expressed (P≤0.02) in squamous cell carcinoma compared with normal skin. 24356192 2015
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 Biomarker disease CTD_human Functional kinomics identifies candidate therapeutic targets in head and neck cancer. 25125259 2015