Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7139
Gene Symbol: TNNT2
TNNT2
0.900 Biomarker group BEFREE Mutations in genes encoding cardiac troponin I (TNNI3) and cardiac troponin T (TNNT2) caused altered troponin protein stoichiometry in patients with dilated cardiomyopathy. 28436080 2018
Entrez Id: 7139
Gene Symbol: TNNT2
TNNT2
0.900 GeneticVariation group BEFREE Carriers of the Arg92Gln mutation developed hypertrophic or dilated cardiomyopathy and had a significantly worse prognosis than those with other mutations in TNNT2 or other sarcomeric genes. 26507537 2017
Entrez Id: 7273
Gene Symbol: TTN
TTN
0.900 Biomarker group BEFREE Inhibition of miR-208b improves cardiac function in titin-based dilated cardiomyopathy. 28065693 2017
Entrez Id: 7273
Gene Symbol: TTN
TTN
0.900 GeneticVariation group BEFREE Improved understanding of dilated cardiomyopathy (DCM) due to titin truncation (TTNtv) may help guide patient stratification. 29073955 2017
Entrez Id: 7139
Gene Symbol: TNNT2
TNNT2
0.900 Biomarker group BEFREE Digenic inheritance of mutations in the cardiac troponin (TNNT2) and cardiac beta myosin heavy chain (MYH7) as the cause of severe dilated cardiomyopathy. 28642161 2017
Entrez Id: 7139
Gene Symbol: TNNT2
TNNT2
0.900 Biomarker group BEFREE Novel Genetic Variants in BAG3 and TNNT2 in a Swedish Family with a History of Dilated Cardiomyopathy and Sudden Cardiac Death. 28669108 2017
Entrez Id: 7139
Gene Symbol: TNNT2
TNNT2
0.900 Biomarker group MGD Gene-Targeted Mice with the Human Troponin T R141W Mutation Develop Dilated Cardiomyopathy with Calcium Desensitization. 27936050 2017
Entrez Id: 7273
Gene Symbol: TTN
TTN
0.900 GeneticVariation group BEFREE Truncating titin mutations are associated with a mild and treatable form of dilated cardiomyopathy. 27813223 2017
Entrez Id: 7273
Gene Symbol: TTN
TTN
0.900 GeneticVariation group BEFREE Titin-truncating variants (TTNtv) have been detected in a variety of cardiomyopathies and represent the most common cause of dilated cardiomyopathy. 28822653 2017
Entrez Id: 7273
Gene Symbol: TTN
TTN
0.900 GeneticVariation group BEFREE HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy. 26315439 2016
Entrez Id: 7273
Gene Symbol: TTN
TTN
0.900 CausalMutation group CLINVAR Atlas of the clinical genetics of human dilated cardiomyopathy. 25163546 2016
Entrez Id: 7273
Gene Symbol: TTN
TTN
0.900 Biomarker group BEFREE Role of Titin Missense Variants in Dilated Cardiomyopathy. 26567375 2016
Entrez Id: 7273
Gene Symbol: TTN
TTN
0.900 Biomarker group BEFREE Truncating mutations in the giant sarcomeric protein Titin result in dilated cardiomyopathy and skeletal myopathy. 26473617 2016
Entrez Id: 7273
Gene Symbol: TTN
TTN
0.900 GeneticVariation group BEFREE Truncating titin (TTN) mutations, especially in A-band region, represent the most common cause of dilated cardiomyopathy (DCM). 26701604 2016
Entrez Id: 7273
Gene Symbol: TTN
TTN
0.900 CausalMutation group CLINVAR Genetic basis of familial dilated cardiomyopathy patients undergoing heart transplantation. 26899768 2016
Entrez Id: 1756
Gene Symbol: DMD
DMD
0.900 GeneticVariation group BEFREE Early-progressive dilated cardiomyopathy in a family with Becker muscular dystrophy related to a novel frameshift mutation in the dystrophin gene exon 27. 25537791 2016
Entrez Id: 7273
Gene Symbol: TTN
TTN
0.900 Biomarker group BEFREE Antisense-mediated exon skipping: a therapeutic strategy for titin-based dilated cardiomyopathy. 25759365 2016
Entrez Id: 7273
Gene Symbol: TTN
TTN
0.900 GeneticVariation group BEFREE Dilated cardiomyopathy is often triggered by mutations that disrupt the giant protein titin. 25651172 2016
Entrez Id: 7273
Gene Symbol: TTN
TTN
0.900 CausalMutation group CLINVAR Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies. 26735901 2016
Entrez Id: 7273
Gene Symbol: TTN
TTN
0.900 Biomarker group CTD_human Titin-truncating variants (TTNtv) commonly cause dilated cardiomyopathy (DCM). 27869827 2016
Entrez Id: 7273
Gene Symbol: TTN
TTN
0.900 GeneticVariation group BEFREE The recent discovery of heterozygous human mutations that truncate full-length titin (TTN, an abundant structural, sensory, and signaling filament in muscle) as a common cause of end-stage dilated cardiomyopathy (DCM) promises new prospects for improving heart failure management. 25589632 2015
Entrez Id: 7273
Gene Symbol: TTN
TTN
0.900 GeneticVariation group CLINVAR Nonsense mutations in BAG3 are associated with early-onset dilated cardiomyopathy in French Canadians. 25448463 2015
Entrez Id: 7273
Gene Symbol: TTN
TTN
0.900 GeneticVariation group BEFREE The recent discovery of titin mutations being a major cause of dilated cardiomyopathy (DCM) also underpins the importance of mechanosensation and mechanotransduction in the pathogenesis of heart failure. 24531746 2015
Entrez Id: 7273
Gene Symbol: TTN
TTN
0.900 GeneticVariation group CLINVAR Up to 37% of dilated cardiomyopathy cases carry a clinically relevant variant in one of 20 genes, titin (TTN) being the largest contributor (up to 14%). 24503780 2015
Entrez Id: 7273
Gene Symbol: TTN
TTN
0.900 CausalMutation group CLINVAR Up to 37% of dilated cardiomyopathy cases carry a clinically relevant variant in one of 20 genes, titin (TTN) being the largest contributor (up to 14%). 24503780 2015