Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 Biomarker group BEFREE Multivariate analyses on 64 study subjects of varying arsenic exposure levels showed that the association of CCL2/MCP1 plasma protein level with blood arsenic remained significant after adjustment for other risk factors of cardiovascular diseases. 12928151 2003
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 Biomarker group LHGDN This interaction may reflect the new role of MCP-1 as an arteriogenic factor in HD patients with CVD. 15627719 2005
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 Biomarker group CTD_human Soy-isoflavone-enriched foods and inflammatory biomarkers of cardiovascular disease risk in postmenopausal women: interactions with genotype and equol production. 16332659 2005
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 AlteredExpression group BEFREE Thus the augmented MCP-1 expression by ANG II in preadipocytes may provide a new link between obesity and cardiovascular disease. 16705055 2006
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 AlteredExpression group BEFREE We measured CRP (by immunonephelometry) and monocyte expression of TF and MCP-1 (by real-time PCR) in 80 untreated hypertensive patients without clinical cardiovascular disease (CVD) or additional risk factors for CVD compared with 41 controls. 18339698 2008
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 GeneticVariation group LHGDN There was no statistically significant difference in the distribution of MCP-1 genotypes between ESRD patients without CVD and healthy controls. 19014891 2008
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 GeneticVariation group BEFREE There was no statistically significant difference in the distribution of MCP-1 genotypes between ESRD patients without CVD and healthy controls. 19014891 2008
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 Biomarker group BEFREE Monocyte chemoattractant protein-1 (MCP-1) is a potent chemokine and plays an important role in cardiovascular diseases. 19781803 2009
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 Biomarker group BEFREE In conclusion, anti-inflammatory gene therapy targeting MCP-1/CCR2 signal, with a novel NP-mediated gene delivery system, is a potent therapeutic strategy for the treatment of cardiovascular diseases. 22023473 2011
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 Biomarker group BEFREE These results demonstrate that MCPIP may be an important regulator of inflammatory angiogenesis and provide novel mechanistic insights into the link between MCP-1 and cardiovascular diseases. 24008336 2013
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 GeneticVariation group BEFREE Both lower and higher MCP-1 levels are associated with an increased risk of all-cause and CVD mortality among CAD patients. 25786118 2015
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 Biomarker group BEFREE Obesity is associated with elevated monocyte chemoattractant protein-1 (MCP-1), a proinflammatory chemokine related to diabetes and cardiovascular disease. 25994074 2015
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 Biomarker group BEFREE Reduction in ICAM-1 and MCP-1 in human endothelium is an important extent of the use of this drug for treatment of cardiovascular diseases, and NO has an important role in this process. 28371087 2017
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 Biomarker group BEFREE Higher concentrations of urine α1m, MCP-1, and PINP may identify KTRs at higher risk for CVD events and death. 28371433 2017
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 Biomarker group BEFREE This review presents the importance of these monocyte subsets in cardiovascular diseases (CVDs), and sheds light on new strategies for the blocking of the MCP-1/CCR2 axis as a therapeutic goal for treating vascular disorders. 28566450 2017
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 Biomarker group BEFREE Although the serum MCP-1 concentration is higher in patients with than without cardiovascular disease, the precise correlations between the serum MCP-1 concentration and factors associated with smoking and atherosclerosis are unknown. 29098933 2018
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 Biomarker group BEFREE CCL2 played important roles in regulating platelet function and arterial thrombosis through the PKCα-P38MAPK-HSP27 pathway, which might provide theoretical basis for searching new antiplatelet drugs and the treatment for cardiovascular diseases. 29864522 2018
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 Biomarker group BEFREE A novel electrochemical immunosensor was proposed for the detection of monocyte chemoattractant protein-1 (MCP-1), a biomarker of cardiovascular disease. 30826652 2019
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 Biomarker group BEFREE Additionally, CX<sub>3</sub>CL1/CX<sub>3</sub>CR1 or CCL2/CCR2 axes are potential candidates for therapeutic intervention in cardiovascular disorders in metabolic syndrome patients, as their blockade impairs the augmented arterial platelet-Mon1 monocyte aggregate adhesiveness, which is a key event in atherogenesis. 31109070 2019
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 Biomarker group BEFREE To determine the association between MCP-1, FGF-21 and subclinical atherosclerosis [i.e., carotid intima-media thickness (cIMT)] in women without clinical evidence of CVD. 31152776 2019
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 Biomarker group BEFREE Fibroblast growth factor 21 (FGF-21) and monocyte chemoattractant protein 1 (MCP-1) are associated with cardiovascular disease and systemic inflammation. 31429530 2019
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 AlteredExpression group BEFREE Our findings show that CCL2 levels are associated with dyslipidemia, which suggests a role of this cytokine in the pathogenesis of cardiovascular disease in HD patients. 31557637 2020