Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3240
Gene Symbol: HP
HP
0.400 Biomarker group BEFREE 1 ng/mL of Hp and ≥11 848.5 pg/mL of NT-proBNP had the highest risk of death related to cardiovascular disease. 30287475 2019
Entrez Id: 3240
Gene Symbol: HP
HP
0.400 GeneticVariation group BEFREE Recently, studies have shown significant association between the rs2000999 polymorphism in the haptoglobin-encoding gene (HP) and low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) levels, which are important risk factors for cardiovascular diseases. 31574854 2019
Entrez Id: 3240
Gene Symbol: HP
HP
0.400 Biomarker group BEFREE Interaction Between the Haptoglobin Genotype and Vitamin E on Cardiovascular Disease in Diabetes. 28451949 2017
Entrez Id: 3240
Gene Symbol: HP
HP
0.400 GeneticVariation group BEFREE Haptoglobin (Hp) polymorphism generates three common human genotypes (Hp1-1, Hp2-1, and Hp2-2), having functional differences, related to the risk of development of cardiovascular diseases. 24535155 2014
Entrez Id: 3240
Gene Symbol: HP
HP
0.400 Biomarker group BEFREE We investigated the association of Hp and HbA1c with cardiovascular disease (CVD) in the longitudinal, population-based Bruneck Study. 24837587 2014
Entrez Id: 3240
Gene Symbol: HP
HP
0.400 GeneticVariation group BEFREE We studied whether common variants of haptoglobin (Hp), which facilitates the removal of free hemoglobin and protects tissues from heme-iron induced oxidative damage, would modify the inflammatory response to IPH and the risk of unstable carotid stenosis (CS) and major cardiovascular diseases. 24075749 2013
Entrez Id: 3240
Gene Symbol: HP
HP
0.400 GeneticVariation group BEFREE Genetic analysis of haptoglobin polymorphisms with cardiovascular disease and type 2 diabetes in the Diabetes Heart Study. 23399657 2013
Entrez Id: 3240
Gene Symbol: HP
HP
0.400 Biomarker group BEFREE We review the biological mechanisms underlying the interaction between the Hp genotype and DM on CVD and the accumulating evidence in favor of Hp genotyping all individuals with DM and providing antioxidant vitamin E supplementation specifically to Hp 2-2 DM individuals to reduce their CVD morbidity and mortality. 22427005 2012
Entrez Id: 3240
Gene Symbol: HP
HP
0.400 GeneticVariation group BEFREE This manuscript presents an overview of the biology of the haptoglobin genotype and reviews the literature concerning its role in the development of cardiovascular disease among individuals with diabetes mellitus. 22447230 2012
Entrez Id: 3240
Gene Symbol: HP
HP
0.400 GeneticVariation group BEFREE Although no association between haptoglobin genotype and the presence of cardiovascular disease could be identified, we found a significant excess of patients with Hp2-1 genotype among those with refractory hypertension, who also had higher systolic and diastolic blood pressure, and total and LDL cholesterol levels. 22011804 2011
Entrez Id: 3240
Gene Symbol: HP
HP
0.400 GeneticVariation group BEFREE The haptoglobin (Hp) 2-2 genotype is associated with increased risk of cardiovascular disease (CVD) in diabetes (DM). 19769483 2010
Entrez Id: 3240
Gene Symbol: HP
HP
0.400 Biomarker group CTD_human The haptoglobin (Hp) 2-2 genotype is associated with increased risk of cardiovascular disease (CVD) in diabetes (DM). 19769483 2010
Entrez Id: 3240
Gene Symbol: HP
HP
0.400 GeneticVariation group BEFREE Vitamin E reduces cardiovascular disease in individuals with diabetes mellitus and the haptoglobin 2-2 genotype. 20415560 2010
Entrez Id: 3240
Gene Symbol: HP
HP
0.400 GeneticVariation group BEFREE Haptoglobin (Hp) polymorphisms have been suggested to be associated with many pathological conditions including cardiovascular diseases, infectious diseases, and type 2 diabetes. 19682981 2009
Entrez Id: 3240
Gene Symbol: HP
HP
0.400 GeneticVariation group BEFREE In humans, a polymorphism for haptoglobin associated with increased cardiovascular disease is also characterized by increased lesional iron. 18619522 2009
Entrez Id: 3240
Gene Symbol: HP
HP
0.400 GeneticVariation group BEFREE The haptoglobin 2-2 polymorphism is associated with increased production of oxygen free radicals and reduces levels of vitamin E and C; the consequent elevated risk for cardiovascular disease can be prevented by vitamin E supplementation. 18667016 2008
Entrez Id: 3240
Gene Symbol: HP
HP
0.400 GeneticVariation group BEFREE The genetic polymorphism of haptoglobin (HP) has been associated with cardiovascular disease and type 2 diabetes. 18760271 2008
Entrez Id: 3240
Gene Symbol: HP
HP
0.400 GeneticVariation group BEFREE There exists a common allelic polymorphism in the haptoglobin gene, which has recently been strongly associated with the risk of cardiovascular disease in multiple independent cohorts. 16918369 2006
Entrez Id: 3240
Gene Symbol: HP
HP
0.400 GeneticVariation group BEFREE Two common alleles exist at the haptoglobin (Hp) locus, and the Hp2 allele is associated with an increased incidence of cardiovascular disease, specifically in diabetes mellitus (DM). 17082477 2006
Entrez Id: 3240
Gene Symbol: HP
HP
0.400 GeneticVariation group BEFREE Application of pharmacogenomics in the prevention of diabetic cardiovascular disease: mechanistic basis and clinical evidence for utilization of the haptoglobin genotype in determining benefit from antioxidant therapy. 16854468 2006
Entrez Id: 3240
Gene Symbol: HP
HP
0.400 GeneticVariation group BEFREE We have recently demonstrated in multiple independent population-based longitudinal and cross sectional analyses that the haptoglobin 2-2 genotype is associated with an increased risk for diabetic cardiovascular disease. 15662028 2005
Entrez Id: 3240
Gene Symbol: HP
HP
0.400 Biomarker group BEFREE Haptoglobin (Hp) is a polymorphic protein which appears to confer differential susceptibility to bacterial infection and CVD. 15588436 2004
Entrez Id: 3240
Gene Symbol: HP
HP
0.400 GeneticVariation group LHGDN Haptoglobin 2-2 phenotype is associated with decreased ferroxidase activity in smokers. 12867276 2003
Entrez Id: 3240
Gene Symbol: HP
HP
0.400 Biomarker group BEFREE These results suggest that haptoglobin phenotype is an important risk factor in determining susceptibility to cardiovascular disease in obstructive sleep apnea syndrome, which may be mediated by the decreased antioxidant and antiinflammatory actions of the haptoglobin 2 allelic protein product. 12938813 2003
Entrez Id: 3240
Gene Symbol: HP
HP
0.400 GeneticVariation group BEFREE To understand the relationship between the Hp polymorphism and diabetic CVD, we sought to identify differences in antioxidant and scavenging functions between the Hp types and to determine how these functions were modified in diabetes. 12750308 2003