Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker group BEFREE In the general population, lipoprotein(a) [Lp(a)] has been established as an independent causal risk factor for cardiovascular disease. 28336560 2017
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 GeneticVariation group BEFREE Lipoprotein (a) (Lp(a)) is an independent risk factor for cardiovascular disease. 26377243 2016
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker group BEFREE Lipoprotein(a): novel target and emergence of novel therapies to lower cardiovascular disease risk. 26825471 2016
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 GeneticVariation group BEFREE Genetic molecular diagnosis is performed in only 33% of patients while Lipoprotein(a) (Lp(a)) is included in cardiovascular disease risk assessment in 71% of participating Centers. 25936332 2016
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 GeneticVariation group BEFREE Lipoprotein (a) [Lp(a)] is an independent risk factor for cardiovascular disease. 25318824 2015
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 GeneticVariation group BEFREE Through accessing the national medical records of these participants, we evaluate the LPA finding via Mendelian randomization and confirm that these splice variants confer protection from cardiovascular disease (OR = 0.84, P = 3×10⁻⁴), demonstrating for the first time the correlation between very low levels of LPA in humans with potential therapeutic implications for cardiovascular diseases. 25078778 2015
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 GeneticVariation group BEFREE Progress continues to be made in the understanding of Lp(a) metabolism, and Lp(a) levels, rather than apolipoprotein (a) isoform size, have been shown to be more closely related to CVD risk. 24977982 2015
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker group BEFREE What is the ultimate test that lowering lipoprotein(a) is beneficial for cardiovascular disease and aortic stenosis? 25340480 2015
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker group BEFREE Robust epidemiologic and genetic studies have solidified the role of lipoprotein (a) [Lp(a)] as an independent and causal risk factor for cardiovascular disease. 25736345 2015
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 GeneticVariation group BEFREE Lipoprotein(a) is one of the strongest genetically determined risk factors for cardiovascular disease, and patients with chronic kidney disease have major disturbances in lipoprotein(a) metabolism. 24129557 2014
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 AlteredExpression group BEFREE Lipoprotein(a) levels in familial hypercholesterolemia: an important predictor of cardiovascular disease independent of the type of LDL receptor mutation. 24632281 2014
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker group BEFREE Recently published epidemiological and genetic studies strongly suggest a causal relationship of elevated concentrations of lipoprotein (a) [Lp(a)] with cardiovascular disease (CVD), independent of low-density lipoproteins (LDLs), reduced high density lipoproteins (HDL), and other traditional CVD risk factors. 23735860 2014
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 GeneticVariation group BEFREE Lipoprotein(a) (Lp(a)) is associated with cardiovascular disease risk. 23243000 2013
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 GeneticVariation group BEFREE Recent epidemiological and genetic studies have suggested that lipoprotein (a) [Lp(a)] is a causal mediator of cardiovascular disease (CVD). 23041907 2013
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker group BEFREE HoFH patients have aggressive cardiovascular disease that develops from birth due to severe LDLR defects, resulting, in turn, in excess production of Apo B-containing atherogenic lipoproteins (low-density lipoprotein [LDL] and lipoprotein(a)). 22398274 2013
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker group BEFREE Elevated plasma lipoprotein(a) (LPA) levels are recognized as an independent risk factor for cardiovascular diseases. 22930813 2013
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 GeneticVariation group BEFREE To examine the relations between genetic loci, plasma lipoprotein(a) [Lp(a)] levels, and cardiovascular disease (CVD) risk among diabetic patients and compare with the observations in the general population. 21900290 2012
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 GeneticVariation group BEFREE The aim of the present study was to determine whether lipoprotein(a) [Lp(a)], considered a causal risk factor for cardiovascular disease, primarily promotes thrombosis or atherosclerosis. 22516069 2012
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 GeneticVariation group BEFREE Lipoprotein(a) as a potential causal genetic risk factor of cardiovascular disease: a rationale for increased efforts to understand its pathophysiology and develop targeted therapies. 22898069 2012
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 GeneticVariation group BEFREE Lipoprotein(a) [Lp(a)] is a risk factor for cardiovascular disease; we highlight the most recent research initiatives that have sought to define Lp(a)-dependent pathogenicity as well as pharmacologic approaches to lowering Lp(a). 22327610 2012
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 GeneticVariation group BEFREE In 2010, more than 45 years after the initial discovery of lipoprotein(a) [Lp(a)] by Kare Berg, an European Atherosclerosis Society Consensus Panel recommended screening for elevated Lp(a) in people at moderate to high risk of atherosclerotic cardiovascular disease (CVD). 21749171 2012
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker group BEFREE Lipoprotein(a) [Lp(a)] is a cardiovascular disease (CVD) risk factor, where inflammation impacts levels differentially across ethnicity. 21757153 2011
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker group BEFREE Lipoprotein(a) and family history of cardiovascular disease in children with familial dyslipidemias. 21392785 2011
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 GeneticVariation group BEFREE Genetic determinants of LDL, lipoprotein(a), triglyceride-rich lipoproteins and HDL: concordance and discordance with cardiovascular disease risk. 21358543 2011
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 GeneticVariation group BEFREE Although it is well known that Lipoprotein(a) (Lp(a)) is an atherogenic lipoprotein and an independent risk factor for cardiovascular disease, there is no confirmed therapy to decrease Lp(a) or prevent atherosclerosis induced by Lp(a). 20138621 2010