Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation group BEFREE To compare the association of triglyceride-lowering variants in the lipoprotein lipase (LPL) gene and LDL-C-lowering variants in the LDL receptor gene (LDLR) with the risk of cardiovascular disease per unit change in ApoB. 30694319 2019
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 Biomarker group BEFREE A better understanding of the molecular action of LpL will help to devise novel strategies for intervention of a number of diseases, including blood cell or metabolic disorders, as well to inhibit pathways related to CVD and tissue degenerative processes. 30648986 2019
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 Biomarker group BEFREE The human lipoprotein lipase (LPL) is a therapeutic target for obesity, and inhibition of LPL with the approved small molecule agent orlistat has been widely used in clinic to treat obesity-related health problems such as diabetes and cardiovascular diseases. 27097985 2017
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 Biomarker group BEFREE Emerging strategies of targeting lipoprotein lipase for metabolic and cardiovascular diseases. 27771332 2017
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation group BEFREE In the present study, the D9N, N291S, and T495G polymorphisms of the LPL gene were not risk factors for the development of CVD. 26853140 2016
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation group BEFREE LPL polymorphisms and triglycerides were determined and CVD assessed. 24990426 2014
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 Biomarker group BEFREE With ample in-vitro and in-vivo evidence for a role of apoCIII in lipoprotein lipase-mediated triglyceride clearance and remnant removal, it is, thus, an attractive target for the treatment of hypertriglyceridemia and the prevention of cardiovascular disease. 25255477 2014
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation group BEFREE LPL polymorphism (D9N) predicts cardiovascular disease risk directly and through interaction with CETP polymorphism (TaqIB) in women with high HDL cholesterol and CRP. 21146168 2011
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation group BEFREE Hypertriglyceridemia (HTG) is a well-established independent risk factor for cardiovascular disease and the influence of several genetic variants in genes related with triglyceride (TG) metabolism has been described, including LPL, APOA5 and APOE. 20429872 2010
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation group BEFREE Lipoprotein lipase (LPL) 1595 C/G and hepatic lipase (HL) -480 C/T single nucleotide polymorphisms (SNPs) influence lipid profile and predisposition for cardiovascular disease in the general population. 19052449 2008
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation group BEFREE On the basis of this finding, an efficient and simple bioinformatics criterion for assessment of the pathogenic effect of LPL nonsynonymous single nucleotide substitution as a risk factor of CVD has been proposed. 17803213 2008
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation group BEFREE The HindIII and S447X polymorphisms of the lipoprotein lipase (LPL) gene are associated with cardiovascular disease in some populations. 17484619 2007
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 Biomarker group CTD_human Candidate gene polymorphism in cardiovascular disease: the BIP cohort. 16544732 2006
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation group BEFREE The frequent lipoprotein lipase S447X variant (LPLS447X) is firmly associated with a lower incidence of cardiovascular disease, the mechanisms for which remain to be established. 16253639 2005
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation group BEFREE Such findings support the active role of placental LPL and APOE in the metabolism of maternal lipoproteins and suggest that fetal genes may modulate the risk for problems related to maternal dyslipidemia (preeclampsia, pancreatitis, and future cardiovascular disease). 16106048 2005
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 Biomarker group BEFREE Polymorphisms of paraoxonase 1 and 2, cholesteryl ester transfer protein, hepatic lipase, and lipoprotein lipase were tested for associations with measures of subclinical CVD including carotid intima-media thickness measured by B-mode ultrasound and carotid and coronary arterial calcification measured by computed tomography. 16141008 2005
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation group BEFREE Lipoprotein lipase gene variants and the effect of environmental factors on cardiovascular disease risk. 14686956 2004
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation group BEFREE There is substantial evidence to suggest that one such gene, lipoprotein lipase (LPL), has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the blood; both independent risk factors for cardiovascular disease. 12652096 2002
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 Biomarker group BEFREE In the field of lipoprotein metabolism and cardiovascular disease several gene polymorphisms for key proteins, such as apoproteins (apo) E, B, A-IV and C-III, LDL receptor, microsomal transfer protein (MTP), fatty acid-binding protein (FABP), cholesteryl ester transfer protein (CETP), lipoprotein lipase and hepatic lipase, have been identified and linked to variable responses to diets. 12691171 2002
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation group BEFREE Subjects were genotyped for the Ser447Stop mutation and for HindIII/PvuII restriction fragment length polymorphisms of the LPL gene, and the findings were investigated for associations with the clinical subtypes of CVD and with lipid levels. 11441189 2001
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation group BEFREE A genetic variant of the LPL gene on chromosome 8p22, Asn291Ser, has previously been associated with dyslipidaemia and an increased frequency of cardiovascular disease as well as familial disorders of lipoprotein metabolism. 11073182 2000
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation group BEFREE The lipoprotein lipase N291S allele is associated with a marginal increase in cardiovascular disease (summary odds ratio 1.25, 95% confidence interval 0.99-1.60, P = 0.07). 10554701 1999
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation group BEFREE These results are consistent with the possibility that apoE, ACE, and LPL genotypes may identify hypertensives who will improve blood pressure, lipoprotein lipids, and cardiovascular disease risk the most with exercise training. 10406818 1999
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation group BEFREE Carriers of N291S or D9N missense mutations in the lipoprotein lipase (LPL) gene exhibit reductions in LPL activity and are predisposed to dyslipidemia and cardiovascular disease. 10636447 1999
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation group BEFREE We investigated the influence of this D9N mutation on lipid and lipoprotein levels and risk for cardiovascular disease (CVD) in patients with familial hypercholesterolemia (FH). 10559015 1999