Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.500 Biomarker phenotype CTD_mouse Manganese superoxide dismutase is a p53-regulated gene that switches cancers between early and advanced stages. 22009531 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.500 Biomarker phenotype CTD_human A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. 15550242 2004
Entrez Id: 1877
Gene Symbol: E4F1
E4F1 		0.300 Biomarker phenotype CTD_human E4F1 silencing inhibits the cell growth through cell-cycle arrest in malignant transformed cells induced by hydroquinone. 30506647 2019
Entrez Id: 55584
Gene Symbol: CHRNA9
CHRNA9 		0.300 Biomarker phenotype CTD_human Long-term exposure to extremely low-dose of nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induce non-malignant breast epithelial cell transformation through activation of the a9-nicotinic acetylcholine receptor-mediated signaling pathway. 30259641 2019
Entrez Id: 2729
Gene Symbol: GCLC
GCLC 		0.300 Therapeutic phenotype CTD_human Down-regulation of GCLC is involved in microcystin-LR-induced malignant transformation of human liver cells. 30940545 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC 		0.300 Biomarker phenotype CTD_human Wnt/β-catenin modulates chronic tobacco smoke exposure-induced acquisition of pulmonary cancer stem cell properties and diallyl trisulfide intervention. 29626521 2018
Entrez Id: 10919
Gene Symbol: EHMT2
EHMT2 		0.300 Biomarker phenotype CTD_human Upregulation of histone-lysine methyltransferases plays a causal role in hexavalent chromium-induced cancer stem cell-like property and cell transformation. 29391238 2018
Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B 		0.300 Biomarker phenotype CTD_human Wnt/β-catenin modulates chronic tobacco smoke exposure-induced acquisition of pulmonary cancer stem cell properties and diallyl trisulfide intervention. 29626521 2018
Entrez Id: 8842
Gene Symbol: PROM1
PROM1 		0.300 Biomarker phenotype CTD_human Wnt/β-catenin modulates chronic tobacco smoke exposure-induced acquisition of pulmonary cancer stem cell properties and diallyl trisulfide intervention. 29626521 2018
Entrez Id: 406991
Gene Symbol: MIR21
MIR21 		0.300 Therapeutic phenotype CTD_human Involvement of HIF-1α-regulated miR-21, acting via the Akt/NF-κB pathway, in malignant transformation of HBE cells induced by cigarette smoke extract. 29501572 2018
Entrez Id: 10550
Gene Symbol: ARL6IP5
ARL6IP5 		0.300 Biomarker phenotype CTD_human JWA deficiency induces malignant transformation of murine embryonic fibroblast cells. 29545876 2018
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		0.300 Biomarker phenotype CTD_human Wnt/β-catenin modulates chronic tobacco smoke exposure-induced acquisition of pulmonary cancer stem cell properties and diallyl trisulfide intervention. 29626521 2018
Entrez Id: 2146
Gene Symbol: EZH2
EZH2 		0.300 Biomarker phenotype CTD_human Upregulation of histone-lysine methyltransferases plays a causal role in hexavalent chromium-induced cancer stem cell-like property and cell transformation. 29391238 2018
Entrez Id: 216
Gene Symbol: ALDH1A1
ALDH1A1 		0.300 Biomarker phenotype CTD_human Wnt/β-catenin modulates chronic tobacco smoke exposure-induced acquisition of pulmonary cancer stem cell properties and diallyl trisulfide intervention. 29626521 2018
Entrez Id: 406966
Gene Symbol: MIR191
MIR191 		0.300 Biomarker phenotype CTD_human MicroRNA-191, regulated by HIF-2α, is involved in EMT and acquisition of a stem cell-like phenotype in arsenite-transformed human liver epithelial cells. 29277653 2018
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A 		0.300 Biomarker phenotype CTD_human Involvement of HIF-1α-regulated miR-21, acting via the Akt/NF-κB pathway, in malignant transformation of HBE cells induced by cigarette smoke extract. 29501572 2018
Entrez Id: 6839
Gene Symbol: SUV39H1
SUV39H1 		0.300 Biomarker phenotype CTD_human Upregulation of histone-lysine methyltransferases plays a causal role in hexavalent chromium-induced cancer stem cell-like property and cell transformation. 29391238 2018
Entrez Id: 406991
Gene Symbol: MIR21
MIR21 		0.300 Biomarker phenotype CTD_human Involvement of HIF-1α-regulated miR-21, acting via the Akt/NF-κB pathway, in malignant transformation of HBE cells induced by cigarette smoke extract. 29501572 2018
Entrez Id: 79923
Gene Symbol: NANOG
NANOG 		0.300 Biomarker phenotype CTD_human Wnt/β-catenin modulates chronic tobacco smoke exposure-induced acquisition of pulmonary cancer stem cell properties and diallyl trisulfide intervention. 29626521 2018
Entrez Id: 5970
Gene Symbol: RELA
RELA 		0.300 Biomarker phenotype CTD_human Involvement of HIF-1α-regulated miR-21, acting via the Akt/NF-κB pathway, in malignant transformation of HBE cells induced by cigarette smoke extract. 29501572 2018
Entrez Id: 406947
Gene Symbol: MIR155
MIR155 		0.300 Biomarker phenotype CTD_human MicroRNA-155 regulates arsenite-induced malignant transformation by targeting Nrf2-mediated oxidative damage in human bronchial epithelial cells. 28688901 2017
Entrez Id: 79605
Gene Symbol: PGBD5
PGBD5 		0.300 Biomarker phenotype CTD_human PGBD5 promotes site-specific oncogenic mutations in human tumors. 28504702 2017
Entrez Id: 4790
Gene Symbol: NFKB1
NFKB1 		0.300 Biomarker phenotype CTD_human The tumor suppressor phosphatase and tensin homolog protein (PTEN) is negatively regulated by NF-κb p50 homodimers and involves histone 3 methylation/deacetylation in UROtsa cells chronically exposed to monomethylarsonous acid. 28823542 2017
Entrez Id: 406991
Gene Symbol: MIR21
MIR21 		0.300 Biomarker phenotype CTD_human Quercetin inhibits Cr(VI)-induced malignant cell transformation by targeting miR-21-PDCD4 signaling pathway. 28881718 2017
Entrez Id: 406991
Gene Symbol: MIR21
MIR21 		0.300 Therapeutic phenotype CTD_human Quercetin inhibits Cr(VI)-induced malignant cell transformation by targeting miR-21-PDCD4 signaling pathway. 28881718 2017