Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 159296
Gene Symbol: NKX2-3
NKX2-3
0.400 GeneticVariation disease BEFREE To generate large-scale evidence on whether NKX2-3 polymorphisms are associated with CD or UC susceptibility we have conducted a meta-analysis of 17 studies involving 17329 patients and 18029 controls. 24473197 2014
Entrez Id: 159296
Gene Symbol: NKX2-3
NKX2-3
0.400 GeneticVariation disease BEFREE We confirmed that the NKX2-3 polymorphism is associated with common susceptibility to IBD and that HLA-DRB1*0450 alleles increase susceptibility to CD but reduce risk for UC while HLA-DRB1*1502 alleles increase susceptibility to UC but reduce CD risk. 23942620 2014
Entrez Id: 159296
Gene Symbol: NKX2-3
NKX2-3
0.400 GeneticVariation disease BEFREE We found 14 SNPs tagging 9 loci, including 21q21.1, NKX2-3, MST1, the HLA region, 1p36.13, IL10, JAK2, ORMDL3, and IL23R, to be associated with UC. 23974994 2013
Entrez Id: 159296
Gene Symbol: NKX2-3
NKX2-3
0.400 AlteredExpression disease BEFREE A positive correlation was observed between mRNA expression of PTPN2 and NKX2-3 in B cells and in intestinal tissues from both CD and UC patients. 22377701 2012
Entrez Id: 159296
Gene Symbol: NKX2-3
NKX2-3
0.400 Biomarker disease BEFREE NKX2-3 may play different roles in UC and CD pathogenesis by differential regulation of EGR1. 21968973 2012
Entrez Id: 159296
Gene Symbol: NKX2-3
NKX2-3
0.400 GeneticVariation disease BEFREE We confirmed the association of SNP rs10883365 located in the 5' flanking region of NKX2-3 with Japanese UC and colonic CD and determined the risk haplotype (haplotype B) for UC. 21514341 2011
Entrez Id: 159296
Gene Symbol: NKX2-3
NKX2-3
0.400 GeneticVariation disease BEFREE Consistent with epidemiologic predictions, many IBD-associated loci demonstrate genome-wide significant associations to both CD and UC, notably, genes whose products function in the interleukin-23 pathway, and transcription factors, including NK2 transcription factor related, locus 3 (NKX2-3), SMAD3, STAT3, ZMIZ1, and c-REL. 21530736 2011
Entrez Id: 159296
Gene Symbol: NKX2-3
NKX2-3
0.400 Biomarker disease BEFREE A correlation with NKX2-3 and need for surgery (P  =  0.038), and with HLA and steroid-responsiveness (P  =  0.024) in UC patients was observed. 21818367 2011
Entrez Id: 159296
Gene Symbol: NKX2-3
NKX2-3
0.400 Biomarker disease CTD_human Genome-wide association identifies multiple ulcerative colitis susceptibility loci. 20228799 2010
Entrez Id: 159296
Gene Symbol: NKX2-3
NKX2-3
0.400 GeneticVariation disease BEFREE NKX2-3 rs10883365 variant allele was associated with increased risk for CD (P = 0.009, OR = 1.24, 95% CI = 1.06-1.48) and UC (P = 0.001, OR = 1.36, 95% CI = 1.13-1.63), whereas variant IRGM allele increased risk for CD (P = 0.029, OR = 1.36, 95% CI = 1.03-1.79). 21049557 2010
Entrez Id: 159296
Gene Symbol: NKX2-3
NKX2-3
0.400 Biomarker disease BEFREE An association between NKX2-3 and UC susceptibility was replicated and diverse evidence of epistasis in Japan was suggested. 19340882 2009
Entrez Id: 159296
Gene Symbol: NKX2-3
NKX2-3
0.400 GeneticVariation disease BEFREE By contrast, variation in the gene encoding the interleukin-23 (IL-23) receptor subunit, as well as in the IL12B, STAT3 and NKX2-3 gene regions, is associated with both Crohn's disease and ulcerative colitis. 18500230 2008
Entrez Id: 159296
Gene Symbol: NKX2-3
NKX2-3
0.400 GeneticVariation disease BEFREE Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection. 18438405 2008
Entrez Id: 159296
Gene Symbol: NKX2-3
NKX2-3
0.400 Biomarker disease CTD_human Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection. 18438405 2008
Entrez Id: 159296
Gene Symbol: NKX2-3
NKX2-3
0.400 GeneticVariation disease LHGDN Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection. 18438405 2008
Entrez Id: 159296
Gene Symbol: NKX2-3
NKX2-3
0.400 Biomarker disease CTD_human We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease. 18438406 2008