| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.370 | GeneticVariation | group | BEFREE | Additionally, carriers of MTHFR 677CT + TT or MTHFR 677CT + TT plus TS 2R/3R + 3R/3R had a 1.55- and a 5.39-fold increased risk for colon tumor, respectively, in comparison with carriers of the wild genotypes. | 21603981 | 2011 | ||||
|
0.370 | GeneticVariation | group | LHGDN | Association of methylenetetrahydrofolate reductase gene polymorphisms and sex-specific survival in patients with metastatic colon cancer. | 17704422 | 2007 | ||||
|
0.370 | GeneticVariation | group | BEFREE | We investigated 2 polymorphisms in the MTHFR gene (C677T and A1298C) and their associations with colon tumor characteristics, including acquired mutations in Ki-ras and p53 genes and microsatellite instability (MSI). | 16177213 | 2005 | ||||
|
0.370 | Biomarker | group | CTD_human | Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancer. | 16284371 | 2005 | ||||
|
0.370 | Biomarker | group | LHGDN | The MTHFR C677T polymorphism and colorectal cancer: the multiethnic cohort study. | 15894672 | 2005 | ||||
|
0.370 | GeneticVariation | group | LHGDN | 5,10-Methylenetetrahydrofolate reductase codon 677 and 1298 polymorphisms and colon cancer in African Americans and whites. | 12496052 | 2002 | ||||
|
0.370 | GeneticVariation | group | BEFREE | The MTHFR TT genotype was more frequent in older CRC patients (>or=70 y) compared with equivalent aged controls (p=0.03), was associated with a significantly later age of diagnosis in patients with proximal colon tumours (p=0.02), and was almost twice as frequent in MSI+ than in MSI- tumours (p=0.05). | 11889073 | 2002 | ||||
|
0.370 | GeneticVariation | group | LHGDN | The exclusive pattern of MTHFR allele loss in cases of LOH, suggest that functional MTHFR activity within a tumor might play an important role in the survival and progression of a colonic neoplasm. | 12540022 | 2001 |