Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression group BEFREE These results reveal that the JB oil acted as a chemopreventive dietary agent, inhibiting cell proliferation and COX-2 expression and inducing apoptosis, resulting in a significant reduction in colon tumor formation. 31617778 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression group BEFREE Interestingly, carcinogenic exposure alone induced multiple colon tumors and increased cyclooxygenase-2 (Ptgs2) expression in Tph1KO mice. 31038736 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression group BEFREE In Apc(Min) (/+) mice, constitutive CpG methylation of the Fxrα3/4 promoter was linked to reduced (60-90%) baseline Fxr, Ibabp, and Shp and increased Cox-2 expression in apparently normal adjacent mucosa and colon tumors. 26609171 2016
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker group CTD_human Western blots revealed overexpression of β-catenin, c-Myc, cyclin D1, inducible nitric oxide synthase and cyclooxygenase-2 in colon tumor samples. 21081470 2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker group BEFREE Western blots revealed overexpression of β-catenin, c-Myc, cyclin D1, inducible nitric oxide synthase and cyclooxygenase-2 in colon tumor samples. 21081470 2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression group BEFREE Butyrate suppresses mRNA increase of osteopontin and cyclooxygenase-2 in human colon tumor tissue. 21459756 2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker group RGD Diclofenac, a selective COX-2 inhibitor, inhibits DMH-induced colon tumorigenesis through suppression of MCP-1, MIP-1α and VEGF. 21268133 2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression group BEFREE Moreover, CCL2 antagonists decreased intracolonic macrophage infiltration and COX-2 expression, attenuated neovascularization, and eventually reduced the numbers and size of colon tumors, even when given after multiple colon tumors have developed. 19773434 2009
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker group BEFREE This study investigated the relationship between E-cadherin and COX-2 in colon cancer cells and human colon tumors. 20046424 2009
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker group BEFREE We examined the functions of HuR and TTP during colon tumorigenesis and their ability to regulate cyclooxygenase (COX-2), a mediator of prostaglandin synthesis that increases in the colon tumor microenvironment. 19208339 2009
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker group BEFREE Collectively, our data indicate that COX-2 promotes colon tumor progression, but not initiation, and it does so, in part, by activating EGFR and Akt signaling pathways. 18790560 2009
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression group LHGDN Cyclooxygenase-2 expression is an independent predictor of poor prognosis in colon cancer. 19088039 2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker group LHGDN Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells. 18326857 2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression group LHGDN Survivin and Cyclooxygenase-2 are co-expressed in human and mouse colon carcinoma and in terminally differentiated colonocytes. 17128412 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker group CTD_human Cyclooxygenase-2 (COX-2) is overexpressed in colon tumors. 17667525 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression group BEFREE Activation of beta-adrenoceptors and the subsequent stimulation of COX-2, PGE(2), and VEGF expression is perhaps an important mechanism in the tumorigenic action of nicotine on colon tumor growth. 17369603 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression group BEFREE Herein, we demonstrate that 15-PGDH is active in vivo as a highly potent suppressor of colon neoplasia development and acts in the colon as a required physiologic antagonist of the prostaglandin-synthesizing activity of the cyclooxygenase 2 (COX-2) oncogene. 16880406 2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression group BEFREE Therefore, we examined the expression of SK1 and COX-2 in rat colon tumors induced by azoxymethane (AOM) and the relationship of these two proteins in normal and malignant intestinal epithelial cells. 16319132 2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker group LHGDN RhoA mediates cyclooxygenase-2 signaling to disrupt the formation of adherens junctions and increase cell motility. 17178865 2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression group BEFREE To further explore how cancer cells exploit the progrowth actions of prostaglandins while suppressing the proapoptotic actions of intracellular arachidonic acid, we determined the cytoplasmic phospholipase A(2) (cPLA(2)) and COX-2 expression levels in a panel of human colon tumors by immunohistochemistry. 15788676 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker group LHGDN The role of cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and vascular endothelial growth factor production in colorectal cancer. 16203768 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression group BEFREE We are interested in the mechanism of cyclooxygenase-2 (Cox-2) regulation in colon cancer cells because this knowledge could provide insight into colon carcinogenesis and suggest ways to suppress Cox-2 expression in colon tumors. 15713675 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression group LHGDN Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways. 15896711 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression group LHGDN Marked increased expression of cyclooxygenase 2 (COX-2), a prostaglandin-synthesizing enzyme that is pharmacologically inhibited by nonsteroid anti-inflammatory-type drugs, is a major early oncogenic event in the genesis of human colon neoplasia. 15574495 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression group BEFREE Marked increased expression of cyclooxygenase 2 (COX-2), a prostaglandin-synthesizing enzyme that is pharmacologically inhibited by nonsteroid anti-inflammatory-type drugs, is a major early oncogenic event in the genesis of human colon neoplasia. 15574495 2004