Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.360 AlteredExpression group BEFREE The mechanism by which sulindac sulfide and the cGMP/PKG pathway inhibits colon tumor cell growth involves the transcriptional suppression of β-catenin to inhibit Wnt/β-catenin T-cell factor transcriptional activity, leading to downregulation of cyclin D1 and survivin. 23804703 2014
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.360 AlteredExpression group BEFREE In a converse experiment, the forced expression of LPP3 in human colon tumor (SW480) cells potentiated tumor growth via increased β-catenin stability and CYCLIN-D1 synthesis. 21569306 2011
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.360 Biomarker group CTD_human Western blots revealed overexpression of β-catenin, c-Myc, cyclin D1, inducible nitric oxide synthase and cyclooxygenase-2 in colon tumor samples. 21081470 2011
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.360 Biomarker group CTD_human Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. 21188121 2011
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.360 AlteredExpression group BEFREE Thus, PKCalpha is a potent negative regulator of cyclin D1 expression and anchorage-independent cell growth in colon tumor cells, findings that offer important perspectives on the frequent loss of this isozyme during intestinal carcinogenesis. 19232344 2009
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.360 Biomarker group CTD_human gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity. 19147571 2009
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.360 Biomarker group CTD_human Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat. 18283038 2008
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.360 AlteredExpression group BEFREE We conclude that ISH of cyclin D1 mRNA is an effective and relatively specific means of detecting activity of this gene in colonic neoplasms. 10749591 2000
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.360 Biomarker group BEFREE Recently defined target genes are c-myc and cyclin D1, linking the APC gene defect to the capacity for autonomous proliferation of colon tumors. 10514384 1999
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.360 AlteredExpression group BEFREE These findings provide direct evidence that increased expression of cyclin D1 in colon tumor cells contributes to their abnormal growth and tumorigenicity. 9108461 1997