Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression group BEFREE GH-deficient prophet of pituitary-specific positive transcription factor 1 (Prop1)(-/-) mice exhibited induced colon p53 levels, and cross-breeding them with Apc(min+/-) mice that normally develop intestinal and colon tumors resulted in GH-deficient double mutants with markedly decreased tumor number and size. 27226307 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker group CTD_human Genomic landscape of cutaneous T cell lymphoma. 26192916 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression group BEFREE Data also suggest that interfering with the integrin α5β1 through the reactivation of p53 by Nutlin-3a may be of valuable interest as a new therapeutic option for colon tumors expressing high level of the integrin and a wild type p53. 23523610 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker group BEFREE Moreover, survival effects of CSNK1A1 together with p53 were also studied.Eighty-three formalin fixed paraffin embedded colon tumors were enriched for tumor cells using flow sorting, the extracted DNA was used in a custom SNP array to determine chr17p13-11 allelic state; p53 immunostaining, TP53 exons 5, 6, 7 and 8 mutations were determined in combination with mRNA expression analysis on frozen tissue. 23739040 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation group BEFREE Germline TP53 mutation c.566C>T results in the missense mutation GCC (Ala) to GTC (Val) at codon 189 (A189V) and has been reported in a case of multiple primary colon tumors. 23667851 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation group BEFREE Examination of miRNAs that were significantly differentially expressed at the 1.5-fold level by tumor phenotype showed 143 unique miRNAs differentially expression for microsatellite instability positive (MSI+) colon tumors; 129 unique miRNAs differentially expressed for CpG Island Methylator Phenotype positive (CIMP+) colon tumors; 135 miRNAs were differentially expressed for KRAS2-mutated colon tumors, and 139 miRNAs were differentially expressed for TP53-mutated colon tumors. 21213373 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation group BEFREE Using fluorescence microscopy and flow cytometry we observed increased dye-effluxing populations in DLD-1 colon tumor cells with mutant p53 versus wild-type (WT) p53-expressing HCT116 cells. 19923899 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation group BEFREE Proximal colon cancers are more likely than rectal and distal colon tumors to have microsatellite instability, CpG island methylator phenotype, and Ki-ras mutations, whereas rectal and distal colon tumors are more likely than proximal colon tumors to have a p53 mutation. 19571709 2009
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker group LHGDN The Snail-p53 binding as the new therapeutic target for K-Ras-mutated cancers including pancreatic, lung, and colon cancers. 19107228 2009
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker group LHGDN Pleurotus ostreatus inhibits proliferation of human breast and colon cancer cells through p53-dependent as well as p53-independent pathway. 19020765 2009
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker group LHGDN Resveratrol displays converse dose-related effects on fluorouracil-evoked colon cancer cell apoptosis: the role of p53 is reported. 18497562 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker group LHGDN Lentiviral delivery of small hairpin RNA targeting Tthymidylate kinase in combination with a low dose of doxorubicin as a new approach to kill colon cancer cells regardless of p53 status. 18413751 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation group BEFREE A p53 mutation in exon 5 could be detected in the colon tumor but not in the sinonasal carcinoma, while a K-ras mutation was only present in the tumor of the inner nose. 17084438 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker group CTD_human Comet fluorescence in situ hybridization analysis for oxidative stress-induced DNA damage in colon cancer relevant genes. 17192441 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression group LHGDN Fluorouracil may show translational regulation and control p53 expression in a colon cancer cell line. 17634554 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker group LHGDN p53 directly regulatescarboxylesterase 2expression in a colonic cancer cell line. 16963839 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker group LHGDN Bivariate analysis of p53/BAX proteins possibly may provide further prognostic evidence in colon cancer. 17426704 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker group BEFREE Small-molecule modulators of p53 family signaling and antitumor effects in p53-deficient human colon tumor xenografts. 16835297 2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation group BEFREE MTHFR variants reduce the risk of G:C->A:T transition mutations within the p53 tumor suppressor gene in colon tumors. 16177213 2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation group LHGDN Polymorphisms in some insulin-related genes are associated with an increased risk of colon cancer with specific KRAS2 and TP53 mutations, implying a link between these genetic changes and specific mutational pathways in carcinogenesis. 16448675 2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker group CTD_human Prognostic significance of tumor necrosis factor-related apoptosis-inducing ligand and its receptors in adjuvantly treated stage III colon cancer patients. 17075118 2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation group LHGDN findings of the present study indicate that p53 codon 72 arginine homozygous genotype may represent a genetic predisposing factor for colon cancer development 16552814 2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker group BEFREE However, whereas this pathway is important in wild-type p53 colon tumors, other pathways are also in operation because colon cancer cell lines in which the p53 gene is mutated are also affected by higher concentrations of WMC-79. 16227412 2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation group BEFREE Colon tumors from the case subjects were evaluated for p53 and Ki-ras mutations and microsatellite instability (MSI). 16489531 2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation group BEFREE TP53 mutations were found in 34% of the proximal colon tumors and in 45% of the distal colon and rectal tumors. 16172461 2005