Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 324
Gene Symbol: APC
APC
0.800 GeneticVariation disease BEFREE Mutations in the adenomatous polyposis coli (APC) gene initiate the majority of both sporadic and hereditary colorectal cancers (CRC) and around 30% of these mutations are nonsense mutations. 31283021 2020
Entrez Id: 324
Gene Symbol: APC
APC
0.800 GeneticVariation disease BEFREE APC gene pathogenic variants are characterized by a lifetime risk of nearly 100% to develop a colorectal carcinoma. 31802619 2020
Entrez Id: 324
Gene Symbol: APC
APC
0.800 GeneticVariation disease BEFREE Colorectal cancer (CRC) development is characterized by the stepwise accumulation of mutations over time, of which mutations in the tumor suppressor APC are often very early to occur. 30799131 2020
Entrez Id: 324
Gene Symbol: APC
APC
0.800 GeneticVariation disease BEFREE IMPLICATIONS: The tumor-suppressive function of APC, the most frequently mutated gene in colorectal cancer, is mainly attributed to its role in β-catenin/Wnt signaling. 31160382 2019
Entrez Id: 324
Gene Symbol: APC
APC
0.800 GeneticVariation disease BEFREE Colorectal cancers (CRCs) initiate through distinct mutations, including in APC pathway components leading to tubular adenomas (TAs); in BRAF, with epigenetic silencing of CDX2, leading to serrated adenomas (SAs); and in the DNA mismatch repair machinery driving microsatellite instability (MSI). 30716341 2019
Entrez Id: 324
Gene Symbol: APC
APC
0.800 GeneticVariation disease BEFREE One of the major characteristics of CRC is enhanced Wnt signaling caused by loss-of-function mutations in the adenomatous polyposis coli (APC) gene. 30867802 2019
Entrez Id: 324
Gene Symbol: APC
APC
0.800 AlteredExpression disease BEFREE WNT signaling activation in colorectal cancers (CRCs) occurs through APC inactivation or β-catenin mutations. 31804558 2019
Entrez Id: 324
Gene Symbol: APC
APC
0.800 Biomarker disease BEFREE We also discuss the diagnostic and prognostic value of the APC gene in the pathogenesis of CRC for a better understanding of CRC disease. 30414835 2019
Entrez Id: 324
Gene Symbol: APC
APC
0.800 GeneticVariation disease BEFREE PET/CT-derived radiomics can provide supplemental information to determine KRAS, TP53, and APC genetic alterations in CRC. 29948642 2019
Entrez Id: 324
Gene Symbol: APC
APC
0.800 Biomarker disease BEFREE The adenomatous polyposis coli (APC) gene plays a pivotal role in the pathogenesis of colorectal carcinoma (CRC) but remains a challenge for drug development. 30511962 2019
Entrez Id: 324
Gene Symbol: APC
APC
0.800 GeneticVariation disease BEFREE After filtering, 15 pathogenic germline variants (9.9%) were found in 15 patients, arising from 9 genes of varying penetrance for colorectal cancer (APC (n = 2; 13%), ATM (n = 1; 6%), BRCA1 (n = 2; 13%), CDH1 (n = 2; 13%), CHEK2 (n = 4; 27%), MSH2 (n = 1; 7%), MSH6 (n = 1; 7%), NF2 (n = 1; 7%), and TP53 (n = 1; 7%)). 30730459 2019
Entrez Id: 324
Gene Symbol: APC
APC
0.800 Biomarker disease BEFREE To further investigate the role of Wntless in tumorigenesis, APC-deficient spontaneous intestinal tumors and chemical induced colorectal cancer mouse models were employed. 31547988 2019
Entrez Id: 324
Gene Symbol: APC
APC
0.800 Biomarker disease BEFREE The remaining case was CIMP negative and MMR proficient in both the components, harbored a BRAF mutation in the SSA/P counterpart, whereas the CRC one was APC and TP53 mutated and showed p16 and β-catenin dysregulation. 30738693 2019
Entrez Id: 324
Gene Symbol: APC
APC
0.800 GeneticVariation disease BEFREE Genetic factors such as germline MLH1 and APC mutations have an aetiologic role, predisposing individuals to CRC. 31455888 2019
Entrez Id: 324
Gene Symbol: APC
APC
0.800 GeneticVariation disease BEFREE The classical genetic model of colorectal cancer presents APC mutations as the earliest genomic alterations, followed by KRAS and TP53 mutations. 31416464 2019
Entrez Id: 324
Gene Symbol: APC
APC
0.800 GeneticVariation disease BEFREE Truncating mutations of APC generated by CRISPR/Cas9 strongly synergize with MEK inhibitors in enhancing Wnt responses in isogenic CRC models. 31097693 2019
Entrez Id: 324
Gene Symbol: APC
APC
0.800 GeneticVariation disease BEFREE We studied thirteen single nucleotide polymorphisms (SNPs) located in SFRP3 (rs7775), CTNNB1 (β-catenin) [rs4135385, rs13072632], APC (rs454886, rs459552), LRP6 (rs2075241, rs2284396), DKK4 (rs3763511), DKK3 (rs6485350), TCF4 (rs12255372) and AXIN2 (rs3923086, rs3923087, rs4791171) in patients with colorectal cancer (n = 122) and controls (n = 110). 31485167 2019
Entrez Id: 324
Gene Symbol: APC
APC
0.800 GeneticVariation disease BEFREE The adenomatous polyposis coli (APC) gene is mutated within specific sequence contexts in colorectal carcinomas but the underlying mechanism is not fully understood. 31732732 2019
Entrez Id: 324
Gene Symbol: APC
APC
0.800 GeneticVariation disease GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019
Entrez Id: 324
Gene Symbol: APC
APC
0.800 GeneticVariation disease BEFREE Inactivation of the Adenomatous polyposis coli (APC) gene is an initiating and the most relevant event in most sporadic cases of colorectal cancer, providing a rationale for using Apc-mutant mice as the disease model. 30637899 2019
Entrez Id: 324
Gene Symbol: APC
APC
0.800 GeneticVariation disease BEFREE The adenomatous polyposis coli (APC) gene is mutated in familial adenomatous polyposis and in the majority of sporadic CRCs. 31414579 2019
Entrez Id: 324
Gene Symbol: APC
APC
0.800 GeneticVariation disease BEFREE Colorectal cancer is a complex disease driven by well-established mutations such as APC and other yet to be identified pathways. 31213502 2019
Entrez Id: 324
Gene Symbol: APC
APC
0.800 GeneticVariation disease BEFREE To obtain new insights into the mechanisms underlying APC mutation and to elucidate the mechanisms of CRC development, we performed to identify the potential metabolites in FAP based on metabolomic strategy. 30983515 2019
Entrez Id: 324
Gene Symbol: APC
APC
0.800 GeneticVariation disease BEFREE We also identified apoptosis-related genes enriched with ancestor mutations in lung cancers and a relationship between APC hotspot mutations and TP53 mutations in colorectal cancers. 29697365 2018
Entrez Id: 324
Gene Symbol: APC
APC
0.800 Biomarker disease BEFREE The wnt/APC/<i>β</i>-catenin pathway is a critical initiator in colorectal carcinogenesis in both hereditary and sporadic colorectal cancer (CRC). 30186819 2018