×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.500
GeneticVariation
group
BEFREE
Mutation or deletion of Smad4 is found in about 50% of pancreatic tumors and in about 15% of colorectal tumors .
16135802
2005
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.500
AlteredExpression
group
BEFREE
We examined the immunohistochemical expression of Smad4 and frequency of KRAS mutation in primary colorectal tumors and in their corresponding metastatic tissues.
17390050
2007
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.500
Biomarker
group
BEFREE
Importantly, our analyses revealed that, while known CRC driver genes APC and SMAD4 were disrupted in both human colorectal tumors and tumors from ApcMin/+ mice, the questionable MCC gene was disrupted in human tumors but appeared to be intact in mouse tumors.
20707908
2010
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.500
GeneticVariation
group
BEFREE
These results indicate that mutations in DPC4 (SMAD4 ) play a significant role in the malignant progression of colorectal tumors .
9506519
1998
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.500
Biomarker
group
BEFREE
DCC and Smad4 aberrations have been previously identified in pancreatic and colorectal tumors .
10698524
2000
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.500
AlteredExpression
group
BEFREE
Loss of Smad4 expression was observed in 42/304 (14%) colorectal tumors and was associated with reduced numbers of S100A8-positive (P = 0.03) but not S100A9-positive stromal cells (P = 0.26).
20622003
2010
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.500
GeneticVariation
group
BEFREE
These results indicate that mutations in SMAD4 play a significant role in the malignant progression of colorectal tumors .
11197776
2000
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.500
GeneticVariation
group
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.500
CausalMutation
group
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.500
CausalMutation
group
CLINVAR
Transcriptional control by the TGF-beta/Smad signaling system.
10775259
2000
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.500
CausalMutation
group
CLINVAR
Role of Smad4 (DPC4) inactivation in human cancer.
12821112
2003
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.500
CausalMutation
group
CLINVAR
Inactivation of both alleles of the DPC4/SMAD4 gene in advanced colorectal cancers: identification of seven novel somatic mutations in tumors from Japanese patients.
10479724
1999
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.500
CausalMutation
group
CLINVAR
Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells.
14715079
2004
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.500
CausalMutation
group
CLINVAR
Somatic alterations of the DPC4 gene in human colorectal cancers in vivo.
8898652
1996
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.500
CausalMutation
group
CLINVAR
Novel mutations in Smad proteins that inhibit signaling by the transforming growth factor beta in mammalian cells.
17994767
2007
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.500
CausalMutation
group
CLINVAR
TGF-beta signaling and cancer: structural and functional consequences of mutations in Smads.
9679244
1998
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.500
Biomarker
group
CTD_human
SMAD4--molecular gladiator of the TGF-beta signaling is trampled upon by mutational insufficiency in colorectal carcinoma of Kashmiri population: an analysis with relation to KRAS proto-oncogene.
20565773
2010
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.500
Biomarker
group
CTD_human
Highly Expressed Genes in Rapidly Proliferating Tumor Cells as New Targets for Colorectal Cancer Treatment.
25944804
2015
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.500
Biomarker
group
CTD_human
SMAD4 levels and response to 5-fluorouracil in colorectal cancer.
16144935
2005
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.500
GeneticVariation
group
LHGDN
Analysis of SMAD4/DPC4 gene alterations in multiploid colorectal carcinomas.
16082587
2005
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.500
GeneticVariation
group
LHGDN
Infrequent mutation of the tumour-suppressor gene Smad4 in early-stage colorectal cancer.
12569386
2003
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.500
AlteredExpression
group
LHGDN
We examined the immunohistochemical expression of Smad4 and frequency of KRAS mutation in primary colorectal tumors and in their corresponding metastatic tissues.
17390050
2007
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.500
GeneticVariation
group
LHGDN
Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells.
14715079
2004
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.500
AlteredExpression
group
LHGDN
Status of the DPC4 tumor suppressor gene in sporadic colon adenocarcinoma of Croatian patients: identification of a novel somatic mutation.
15063137
2004