Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 GeneticVariation group BEFREE Mutation or deletion of Smad4 is found in about 50% of pancreatic tumors and in about 15% of colorectal tumors. 16135802 2005
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 AlteredExpression group BEFREE We examined the immunohistochemical expression of Smad4 and frequency of KRAS mutation in primary colorectal tumors and in their corresponding metastatic tissues. 17390050 2007
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 Biomarker group BEFREE Importantly, our analyses revealed that, while known CRC driver genes APC and SMAD4 were disrupted in both human colorectal tumors and tumors from ApcMin/+ mice, the questionable MCC gene was disrupted in human tumors but appeared to be intact in mouse tumors. 20707908 2010
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 GeneticVariation group BEFREE These results indicate that mutations in DPC4 (SMAD4) play a significant role in the malignant progression of colorectal tumors. 9506519 1998
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 Biomarker group BEFREE DCC and Smad4 aberrations have been previously identified in pancreatic and colorectal tumors. 10698524 2000
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 AlteredExpression group BEFREE Loss of Smad4 expression was observed in 42/304 (14%) colorectal tumors and was associated with reduced numbers of S100A8-positive (P = 0.03) but not S100A9-positive stromal cells (P = 0.26). 20622003 2010
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 GeneticVariation group BEFREE These results indicate that mutations in SMAD4 play a significant role in the malignant progression of colorectal tumors. 11197776 2000
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 GeneticVariation group CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 CausalMutation group CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 CausalMutation group CLINVAR Transcriptional control by the TGF-beta/Smad signaling system. 10775259 2000
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 CausalMutation group CLINVAR Role of Smad4 (DPC4) inactivation in human cancer. 12821112 2003
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 CausalMutation group CLINVAR Inactivation of both alleles of the DPC4/SMAD4 gene in advanced colorectal cancers: identification of seven novel somatic mutations in tumors from Japanese patients. 10479724 1999
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 CausalMutation group CLINVAR Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells. 14715079 2004
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 CausalMutation group CLINVAR Somatic alterations of the DPC4 gene in human colorectal cancers in vivo. 8898652 1996
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 CausalMutation group CLINVAR Novel mutations in Smad proteins that inhibit signaling by the transforming growth factor beta in mammalian cells. 17994767 2007
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 CausalMutation group CLINVAR TGF-beta signaling and cancer: structural and functional consequences of mutations in Smads. 9679244 1998
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 Biomarker group CTD_human SMAD4--molecular gladiator of the TGF-beta signaling is trampled upon by mutational insufficiency in colorectal carcinoma of Kashmiri population: an analysis with relation to KRAS proto-oncogene. 20565773 2010
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 Biomarker group CTD_human Highly Expressed Genes in Rapidly Proliferating Tumor Cells as New Targets for Colorectal Cancer Treatment. 25944804 2015
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 Biomarker group CTD_human SMAD4 levels and response to 5-fluorouracil in colorectal cancer. 16144935 2005
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 GeneticVariation group LHGDN Analysis of SMAD4/DPC4 gene alterations in multiploid colorectal carcinomas. 16082587 2005
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 GeneticVariation group LHGDN Infrequent mutation of the tumour-suppressor gene Smad4 in early-stage colorectal cancer. 12569386 2003
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 AlteredExpression group LHGDN We examined the immunohistochemical expression of Smad4 and frequency of KRAS mutation in primary colorectal tumors and in their corresponding metastatic tissues. 17390050 2007
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 GeneticVariation group LHGDN Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells. 14715079 2004
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 AlteredExpression group LHGDN Status of the DPC4 tumor suppressor gene in sporadic colon adenocarcinoma of Croatian patients: identification of a novel somatic mutation. 15063137 2004