Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.400 Biomarker group BEFREE This study aimed to identify low-level constitutional MLH1 epimutations and determine its causal role in patients with MLH1-hypermethylated colorectal cancer.Eighteen patients with MLH1-hypermethylated colorectal tumors in whom MLH1 methylation was previously undetected in blood by methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) were screened for MLH1 methylation using highly sensitive MS-melting curve analysis (MS-MCA). 31779681 2019
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.400 PosttranslationalModification group BEFREE HES1 loss correlates with the development of human right-sided colorectal tumors with epigenetic loss of MLH1. 27639802 2017
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.400 GeneticVariation group BEFREE We investigated the clinical and molecular features of the MSH6 variants, such as the family cancer history, pathological findings, immunohistochemistry, methylation status of the MLH1 promoter and BRAF mutation in the colorectal tumor. 24100870 2013
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.400 Biomarker group BEFREE Analysis of colorectal tumors from probands included a microsatellite instability study and immunohistochemical evaluation for MLH1 and MSH2. 20305446 2010
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.400 Biomarker group BEFREE These preliminary data suggest that lower MLH1 expression in the normal colonic mucosa, at least in the ascending colon, may be associated with increased risk of incident, sporadic colorectal adenoma, as well as with modifiable risk factors for colorectal neoplasms, thus supporting further investigation of MLH1 expression as a potential "treatable" biomarker of risk for colorectal neoplasms. 19423536 2009
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.400 PosttranslationalModification group LHGDN Deficient mismatch repair system in patients with sporadic advanced colorectal cancer. 19165197 2009
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.400 GeneticVariation group LHGDN Microsatellite instability, MLH1 promoter methylation, and BRAF mutation analysis in sporadic colorectal cancers of different ethnic groups in Israel. 19127559 2009
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.400 Biomarker group CTD_human Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study. 18718023 2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.400 GeneticVariation group LHGDN MLH1 -93G>A promoter polymorphism and risk of mismatch repair deficient colorectal cancer. 18712731 2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.400 PosttranslationalModification group LHGDN Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening. 18990764 2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.400 AlteredExpression group LHGDN Sporadic colon cancer: mismatch repair immunohistochemistry and microsatellite instability in Omani subjects. 18299982 2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.400 AlteredExpression group LHGDN Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study. 18718023 2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.400 Biomarker group LHGDN Oncoprotein Bcl-2 and microsatellite instability are associated with disease-free survival and treatment response in colorectal cancer. 18949393 2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.400 AlteredExpression group LHGDN Fhit, Mlh1, P53 and phenotypic expression in the early stage of colorectal neoplasms. 18097574 2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.400 Biomarker group CTD_human Oncoprotein Bcl-2 and microsatellite instability are associated with disease-free survival and treatment response in colorectal cancer. 18949393 2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.400 AlteredExpression group BEFREE Fhit, Mlh1, P53 and phenotypic expression in the early stage of colorectal neoplasms. 18097574 2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.400 PosttranslationalModification group LHGDN Redundant DNA methylation in colorectal cancers of Lynch-syndrome patients. 18618713 2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.400 AlteredExpression group LHGDN Expression of the hMLH1 gene is a possible predictor for the clinical response to 5-fluorouracil after a surgical resection in colorectal cancer. 18497967 2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.400 Biomarker group CTD_human Expression of the hMLH1 gene is a possible predictor for the clinical response to 5-fluorouracil after a surgical resection in colorectal cancer. 18497967 2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.400 GeneticVariation group LHGDN Reduced mRNA expression in paraffin-embedded tissue identifies MLH1- and MSH2-deficient colorectal tumours and potential mutation carriers. 18581137 2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.400 PosttranslationalModification group LHGDN Further evidence for heritability of an epimutation in one of 12 cases with MLH1 promoter methylation in blood cells clinically displaying HNPCC. 18301449 2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.400 PosttranslationalModification group LHGDN Associations of dietary methyl donor intake with MLH1 promoter hypermethylation and related molecular phenotypes in sporadic colorectal cancer. 18339680 2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.400 GeneticVariation group LHGDN Phenotype comparison of MLH1 and MSH2 mutation carriers in a cohort of 1,914 individuals undergoing clinical genetic testing in the United States. 18708397 2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.400 PosttranslationalModification group LHGDN Coexisting somatic promoter hypermethylation and pathogenic MLH1 germline mutation in Lynch syndrome. 17973250 2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.400 GeneticVariation group BEFREE The patient with the epimutation had developed an epidermoid lip carcinoma and an early-onset colorectal tumor with MSI, no MLH1 expression, and loss of heterozygosity of the gene. 17309645 2007