×
Entrez Id:
4292
Gene Symbol:
MLH1
MLH1
0.400
Biomarker
group
BEFREE
This study aimed to identify low-level constitutional MLH1 epimutations and determine its causal role in patients with MLH1 -hypermethylated colorectal cancer.Eighteen patients with MLH1 -hypermethylated colorectal tumors in whom MLH1 methylation was previously undetected in blood by methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) were screened for MLH1 methylation using highly sensitive MS-melting curve analysis (MS-MCA).
31779681
2019
×
Entrez Id:
4292
Gene Symbol:
MLH1
MLH1
0.400
PosttranslationalModification
group
BEFREE
HES1 loss correlates with the development of human right-sided colorectal tumors with epigenetic loss of MLH1 .
27639802
2017
×
Entrez Id:
4292
Gene Symbol:
MLH1
MLH1
0.400
GeneticVariation
group
BEFREE
We investigated the clinical and molecular features of the MSH6 variants, such as the family cancer history, pathological findings, immunohistochemistry, methylation status of the MLH1 promoter and BRAF mutation in the colorectal tumor .
24100870
2013
×
Entrez Id:
4292
Gene Symbol:
MLH1
MLH1
0.400
Biomarker
group
BEFREE
Analysis of colorectal tumors from probands included a microsatellite instability study and immunohistochemical evaluation for MLH1 and MSH2.
20305446
2010
×
Entrez Id:
4292
Gene Symbol:
MLH1
MLH1
0.400
Biomarker
group
BEFREE
These preliminary data suggest that lower MLH1 expression in the normal colonic mucosa, at least in the ascending colon, may be associated with increased risk of incident, sporadic colorectal adenoma, as well as with modifiable risk factors for colorectal neoplasms , thus supporting further investigation of MLH1 expression as a potential "treatable" biomarker of risk for colorectal neoplasms .
19423536
2009
×
Entrez Id:
4292
Gene Symbol:
MLH1
MLH1
0.400
PosttranslationalModification
group
LHGDN
Deficient mismatch repair system in patients with sporadic advanced colorectal cancer.
19165197
2009
×
Entrez Id:
4292
Gene Symbol:
MLH1
MLH1
0.400
GeneticVariation
group
LHGDN
Microsatellite instability, MLH1 promoter methylation, and BRAF mutation analysis in sporadic colorectal cancers of different ethnic groups in Israel.
19127559
2009
×
Entrez Id:
4292
Gene Symbol:
MLH1
MLH1
0.400
Biomarker
group
CTD_human
Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study.
18718023
2008
×
Entrez Id:
4292
Gene Symbol:
MLH1
MLH1
0.400
GeneticVariation
group
LHGDN
MLH1 -93G>A promoter polymorphism and risk of mismatch repair deficient colorectal cancer.
18712731
2008
×
Entrez Id:
4292
Gene Symbol:
MLH1
MLH1
0.400
PosttranslationalModification
group
LHGDN
Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening.
18990764
2008
×
Entrez Id:
4292
Gene Symbol:
MLH1
MLH1
0.400
AlteredExpression
group
LHGDN
Sporadic colon cancer: mismatch repair immunohistochemistry and microsatellite instability in Omani subjects.
18299982
2008
×
Entrez Id:
4292
Gene Symbol:
MLH1
MLH1
0.400
AlteredExpression
group
LHGDN
Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study.
18718023
2008
×
Entrez Id:
4292
Gene Symbol:
MLH1
MLH1
0.400
Biomarker
group
LHGDN
Oncoprotein Bcl-2 and microsatellite instability are associated with disease-free survival and treatment response in colorectal cancer.
18949393
2008
×
Entrez Id:
4292
Gene Symbol:
MLH1
MLH1
0.400
AlteredExpression
group
LHGDN
Fhit, Mlh1 , P53 and phenotypic expression in the early stage of colorectal neoplasms .
18097574
2008
×
Entrez Id:
4292
Gene Symbol:
MLH1
MLH1
0.400
Biomarker
group
CTD_human
Oncoprotein Bcl-2 and microsatellite instability are associated with disease-free survival and treatment response in colorectal cancer.
18949393
2008
×
Entrez Id:
4292
Gene Symbol:
MLH1
MLH1
0.400
AlteredExpression
group
BEFREE
Fhit, Mlh1 , P53 and phenotypic expression in the early stage of colorectal neoplasms .
18097574
2008
×
Entrez Id:
4292
Gene Symbol:
MLH1
MLH1
0.400
PosttranslationalModification
group
LHGDN
Redundant DNA methylation in colorectal cancers of Lynch-syndrome patients.
18618713
2008
×
Entrez Id:
4292
Gene Symbol:
MLH1
MLH1
0.400
AlteredExpression
group
LHGDN
Expression of the hMLH1 gene is a possible predictor for the clinical response to 5-fluorouracil after a surgical resection in colorectal cancer.
18497967
2008
×
Entrez Id:
4292
Gene Symbol:
MLH1
MLH1
0.400
Biomarker
group
CTD_human
Expression of the hMLH1 gene is a possible predictor for the clinical response to 5-fluorouracil after a surgical resection in colorectal cancer.
18497967
2008
×
Entrez Id:
4292
Gene Symbol:
MLH1
MLH1
0.400
GeneticVariation
group
LHGDN
Reduced mRNA expression in paraffin-embedded tissue identifies MLH1- and MSH2-deficient colorectal tumours and potential mutation carriers.
18581137
2008
×
Entrez Id:
4292
Gene Symbol:
MLH1
MLH1
0.400
PosttranslationalModification
group
LHGDN
Further evidence for heritability of an epimutation in one of 12 cases with MLH1 promoter methylation in blood cells clinically displaying HNPCC.
18301449
2008
×
Entrez Id:
4292
Gene Symbol:
MLH1
MLH1
0.400
PosttranslationalModification
group
LHGDN
Associations of dietary methyl donor intake with MLH1 promoter hypermethylation and related molecular phenotypes in sporadic colorectal cancer.
18339680
2008
×
Entrez Id:
4292
Gene Symbol:
MLH1
MLH1
0.400
GeneticVariation
group
LHGDN
Phenotype comparison of MLH1 and MSH2 mutation carriers in a cohort of 1,914 individuals undergoing clinical genetic testing in the United States.
18708397
2008
×
Entrez Id:
4292
Gene Symbol:
MLH1
MLH1
0.400
PosttranslationalModification
group
LHGDN
Coexisting somatic promoter hypermethylation and pathogenic MLH1 germline mutation in Lynch syndrome.
17973250
2008
×
Entrez Id:
4292
Gene Symbol:
MLH1
MLH1
0.400
GeneticVariation
group
BEFREE
The patient with the epimutation had developed an epidermoid lip carcinoma and an early-onset colorectal tumor with MSI, no MLH1 expression, and loss of heterozygosity of the gene.
17309645
2007