Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group BEFREE Risks of colorectal neoplasms and cardiovascular thromboembolic events after the combined use of selective COX-2 inhibitors and aspirin with 5-year follow-up: a meta-analysis. 30656820 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group BEFREE However, the downstream prostaglandin (PG)-PG receptor pathway involved in these effects is poorly characterized.We studied the PG-pathway in gene expression databases and we found that PTGS2 (prostaglandin G/H synthase and cyclooxygenase) and PTGES (prostaglandin E synthase) are co-expressed in human colorectal tumors. 26498686 2015
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group BEFREE Levels of COX-2 mRNA are found over-expressed in almost 80% of the colorectal tumors, compared to paired adjacent normal colorectal mucosa, suggesting a role of COX-2 as a potential biomarker for cancer risk, whereas inhibitors of COX-2 could be of value in chemoprevention of colon cancer. 24383454 2014
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group BEFREE COX-2 overexpression is a frequent, but not universal event in colorectal neoplasms. 21158711 2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group CTD_human Cyclooxygenase-2 expression and recurrence of colorectal adenomas: effect of aspirin chemoprevention. 20427397 2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group BEFREE Bioactive metabolites downstream of cyclooxygenase-2 (COX-2) generated prostaglandin H(2) (PGH(2)), in particular prostaglandin E(2) (PGE(2)), are thought to play critical roles during the development of colorectal tumors. 19035518 2009
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group CTD_human Aspirin use and survival after diagnosis of colorectal cancer. 19671906 2009
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group LHGDN Detection of colorectal cancer cells from feces using quantitative real-time RT-PCR for colorectal cancer diagnosis. 19016757 2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group LHGDN Proline oxidase, a p53-induced gene, targets COX-2/PGE2 signaling to induce apoptosis and inhibit tumor growth in colorectal cancers. 18794809 2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 GeneticVariation group LHGDN Polymorphisms in cyclooxygenase-2 and epidermal growth factor receptor are associated with progression-free survival independent of K-ras in metastatic colorectal cancer patients treated with single-agent cetuximab. 19047118 2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 GeneticVariation group LHGDN Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer. 17151091 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group LHGDN Expression of cyclooxygenase-2 and its relationship to p53 accumulation in colorectal cancers. 17594159 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group LHGDN An upstream CRE-E-box element is essential for gastrin-dependent activation of the cyclooxygenase-2 gene in human colon cancer cells. 17604853 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group LHGDN Coexpression of VEGF-C and Cox-2 in human colorectal cancer and its association with lymph node metastasis. 16474989 2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group BEFREE Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia. 16818642 2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group LHGDN Combined analysis of COX-2 and p53 expressions reveals synergistic inverse correlations with microsatellite instability and CpG island methylator phenotype in colorectal cancer. 16820091 2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group CTD_human Prostaglandin E2 enhances intestinal adenoma growth via activation of the Ras-mitogen-activated protein kinase cascade. 15753380 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group BEFREE Overexpression of COX-2 and iNOS mRNA expression was observed in 42.2% and 66.7% of the 90 colorectal tumors, respectively. 15695237 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group LHGDN Lysophosphatidic acid transactivates both c-Met and epidermal growth factor receptor, and induces cyclooxygenase-2 expression in human colon cancer LoVo cells. 16237757 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 GeneticVariation group LHGDN Analysis of K-ras mutations and expression of cyclooxygenase-2 and gastrin protein in laterally spreading tumors. 16174078 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group LHGDN Cyclooxygenase-2 expression in primary human colorectal cancers and bone marrow micrometastases. 15248379 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group LHGDN RNA profiling of cyclooxygenases 1 and 2 in colorectal cancer. 15328521 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group LHGDN Cyclooxygenase-2 activation mediates the proangiogenic effect of nitric oxide in colorectal cancer. 15102673 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group BEFREE In addition, overexpression of COX-2 was found more frequently in colorectal tumors with lymphatic invasion, regional lymph node metastasis and larger size, although without statistical significance. 15075004 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group BEFREE Cyclooxygenase 2 (COX-2) is overexpressed frequently in aerodigestive tumors, especially in colorectal tumors. 15300574 2004