Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker group BEFREE To clarify the roles of vitamin D and calcium as potential chemopreventive agents against colorectal cancer in humans, and to develop "treatable", pre-neoplastic, phenotypic biomarkers of risk for colorectal neoplasms, we estimated the effects of supplemental vitamin D3 (1,000 IU/day [25 μg/day]) and calcium (1,200 mg/day), alone and in combination, on biomarkers of proliferation (mib-1), differentiation (p21), and apoptosis (bax [apoptosis-promoting] and bcl-2 [apoptosis-inhibiting]), in the normal-appearing rectal mucosa in a subsample of participants (n = 104) in a larger randomized, double-blind, placebo-controlled clinical trial among colorectal adenoma patients. 30557404 2018
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker group BEFREE We found that the HIF-1α gene expression, HIF-1α protein concentration, and IHC expression of HIF-1α, GLUT-1, Ki-67, and Bcl-2 were not systematically affected by either the fixation or freezing delay of the tissue, the perioperative ischemia time, or the total ischemia time (perioperative ischemia+delay of fixation or freezing) in colorectal tumors. 23060299 2013
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker group LHGDN Oncoprotein Bcl-2 and microsatellite instability are associated with disease-free survival and treatment response in colorectal cancer. 18949393 2008
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker group CTD_human Oncoprotein Bcl-2 and microsatellite instability are associated with disease-free survival and treatment response in colorectal cancer. 18949393 2008
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker group LHGDN p53 and p27 as predictors of clinical outcome for rectal-cancer patients receiving neoadjuvant therapy. 17360176 2006
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 AlteredExpression group BEFREE Loss of pSer70 Bcl-2 expression is closely linked to biological aggressiveness in colorectal tumors and represents a statistically significant molecular index for prognosis of patients with these tumors. 16243795 2005
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 AlteredExpression group LHGDN Prognostic significance of bcl-2 and p53 expression in colorectal carcinoma. 16358373 2005
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 AlteredExpression group LHGDN p53, Bcl-2 and C-Myc expressions in colorectal carcinoma associated with schistosomiasis in Egypt. 16308474 2005
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 AlteredExpression group LHGDN Loss of pSer70 Bcl-2 expression is closely linked to biological aggressiveness in colorectal tumors and represents a statistically significant molecular index for prognosis of patients with these tumors. 16243795 2005
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 AlteredExpression group LHGDN Potential role of bcl-2 and ki-67 expression and apoptosis in colorectal carcinoma: a clinicopathologic study. 14627346 2003
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker group LHGDN Bcl-2 constitutively suppresses p53-dependent apoptosis in colorectal cancer cells. 12670866 2003
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 GeneticVariation group BEFREE The aim of this study was to determine the frequency of apoptosis in colorectal neoplasms and to examine its relationship to a number of pathological parameters, to the presence of mutations in the p53 tumor suppressor gene, and to overexpression of the bcl-2 oncoprotein. 9143411 1997
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker group BEFREE Thus, a shift from expression of the anti-apoptotic proteins Bcl-2 and Mcl-1 to the Bcl-XL protein may occur during progression of colorectal tumors. 8625322 1996