×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.500
CausalMutation
group
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011 2016
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.500
CausalMutation
group
CLINVAR
Cetuximab treatment for metastatic colorectal cancer with KRAS p.G13D mutations improves progression-free survival.
26623049 2015
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.500
GeneticVariation
group
CLINVAR
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
25157968 2014
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.500
CausalMutation
group
CLINVAR
KRAS G13D Mutation and Sensitivity to Cetuximab or Panitumumab in a Colorectal Cancer Cell Line Model.
24558511 2014
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.500
CausalMutation
group
CLINVAR
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
25157968 2014
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.500
CausalMutation
group
CLINVAR
Massively parallel tumor multigene sequencing to evaluate response to panitumumab in a randomized phase III study of metastatic colorectal cancer.
23325582 2013
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.500
CausalMutation
group
CLINVAR
Mutant KRAS codon 12 and 13 alleles in patients with metastatic colorectal cancer: assessment as prognostic and predictive biomarkers of response to panitumumab.
23182985 2013
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.500
CausalMutation
group
CLINVAR
Inhibition of MEK and PI3K/mTOR suppresses tumor growth but does not cause tumor regression in patient-derived xenografts of RAS-mutant colorectal carcinomas.
22392911 2012
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.500
CausalMutation
group
CLINVAR
Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer.
22722830 2012
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.500
CausalMutation
group
CLINVAR
Association of KRAS G13D tumor mutations with outcome in patients with metastatic colorectal cancer treated with first-line chemotherapy with or without cetuximab.
22734028 2012
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.500
CausalMutation
group
CLINVAR
Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study.
21228335 2011
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.500
GeneticVariation
group
CLINVAR
Effect of simvastatin on cetuximab resistance in human colorectal cancer with KRAS mutations.
21398618 2011
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.500
CausalMutation
group
CLINVAR
Effect of simvastatin on cetuximab resistance in human colorectal cancer with KRAS mutations.
21398618 2011
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.500
CausalMutation
group
CLINVAR
Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab.
20978259 2010
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.500
CausalMutation
group
CLINVAR
Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study.
20921465 2010
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.500
CausalMutation
group
CLINVAR
Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer.
20921462 2010
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.500
CausalMutation
group
CLINVAR
Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer.
19679400 2009
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.500
CausalMutation
group
CLINVAR
BRAF(V600E) efficient transformation and induction of microsatellite instability versus KRAS(G12V) induction of senescence markers in human colon cancer cells.
19881948 2009
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.500
CausalMutation
group
CLINVAR
Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer.
19114683 2009
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.500
CausalMutation
group
CLINVAR
Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer.
18316791 2008
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.500
CausalMutation
group
CLINVAR
KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer.
16618717 2006
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.500
CausalMutation
group
CLINVAR
Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma.
16361624 2005