Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 29851
Gene Symbol: ICOS
ICOS
0.800 AlteredExpression disease BEFREE In contrast, circulating follicular helper T-cell frequency and expression of inducible T-cell co-stimulator and chemokine receptors were only significantly altered in patients with common variable immunodeficiency. 27634199 2017
Entrez Id: 29851
Gene Symbol: ICOS
ICOS
0.800 Biomarker disease BEFREE Genes that have been implicated in monogenic CVID include ICOS, TNFRSF13B (TACI), TNFRSF13C (BAFF-R), TNFSF12 (TWEAK), CD19, CD81, CR2 (CD21), MS4A1 (CD20), TNFRSF7 (CD27), IL21, IL21R, LRBA, CTLA4, PRKCD, PLCG2, NFKB1, NFKB2, PIK3CD, PIK3R1, VAV1, RAC2, BLK, IKZF1 (IKAROS) and IRF2BP2 With the increasing number of disease genes identified in CVID, it has become clear that CVID is an umbrella diagnosis and that many of these genetic defects cause distinct disease entities. 27250108 2016
Entrez Id: 29851
Gene Symbol: ICOS
ICOS
0.800 AlteredExpression disease BEFREE Within CXCR5+CD4+ T cells, the percentage of PD-1 (+) was higher and that of CCR7 (+) was lower in Group I than in Group II and N. The percentages of Treg and TFH reg were similar in both CVID groups and in N. TFH responded to stimulation increasing the expression of the costimulatory molecules CD40L and ICOS as did N. After submitogenic PHA+IL-2 stimulation, intracellular expression of TFH cytokines (IL-10, IL-21) was higher than N in Group I, and IL-4 was higher than N in Group II. 27069935 2016
Entrez Id: 29851
Gene Symbol: ICOS
ICOS
0.800 GeneticVariation disease BEFREE Three different classifications, B lymphocyte subpopulations, TNFRSF13B (TACI), TNFRSF13C (BAFF-R), TNFSF13 (APRIL) gene mutations, CTLA-4 and ICOS gene polymorphisms in Turkish patients with common variable immunodeficiency. 22699762 2012
Entrez Id: 29851
Gene Symbol: ICOS
ICOS
0.800 GeneticVariation disease BEFREE The candidate gene approach has led to the detection of associations between common variable immunodeficiency (CVID) and mutations in the genes TACI, ICOS, BAFF-R, CD19, CD20, and CD81. 21905497 2011
Entrez Id: 29851
Gene Symbol: ICOS
ICOS
0.800 GeneticVariation disease BEFREE The discovery of human ICOS deficiency showed that a monogenic disorder could account for the full spectrum of manifestations seen in childhood and adulthood-onset CVID, including autoimmune, inflammatory, and malignant disease complications, as well as recurrent infections. 19426217 2009
Entrez Id: 29851
Gene Symbol: ICOS
ICOS
0.800 GeneticVariation disease BEFREE In addition, the flowcytometric analysis of the inducible costimulator on activated T cells, CD19 and BAFF-R on B cells are valid screening methods for three of the four known genetic defects associated with CVID. 18561200 2008
Entrez Id: 29851
Gene Symbol: ICOS
ICOS
0.800 GeneticVariation disease BEFREE Seven known genetic defects, including Bruton tyrosine kinase (Btk), CD4OL, and signaling lymphocyte activation molecule-associated protein (SAP) (all X-linked) and inducible costimulator molecule (ICOS), transmembrane activator and calcium-modulator and cytophilin ligand interactor (TACI), B-cell-activating factor of the tumor necrosis family receptor (BAFFR), and CD19 (all autosomal recessive), were found in patients with the phenotype of common variable immunodeficiency (CVID). 18051214 2007
Entrez Id: 29851
Gene Symbol: ICOS
ICOS
0.800 Biomarker disease BEFREE Until recently the only known genetic defect specific to CVID was ICOS deficiency that accounts for about 1% of the patients analyzed. 17917015 2007
Entrez Id: 29851
Gene Symbol: ICOS
ICOS
0.800 Biomarker disease BEFREE Recently, several mutations in genes encoding for molecules (CD19, TACI, ICOS) involved in B cell survival and isotype switch have been identified in patients with CVID. 17173844 2007
Entrez Id: 29851
Gene Symbol: ICOS
ICOS
0.800 Biomarker disease BEFREE Human ICOS deficiency is indistinguishable from CVID and thus serves as a monogenic model for this complex syndrome. 16384931 2006
Entrez Id: 29851
Gene Symbol: ICOS
ICOS
0.800 Biomarker disease LHGDN The incidence of ICOS deficiency among patients with CVID is less than 5%. 15507387 2004
Entrez Id: 29851
Gene Symbol: ICOS
ICOS
0.800 Biomarker disease BEFREE The incidence of ICOS deficiency among patients with CVID is less than 5%. 15507387 2004
Entrez Id: 29851
Gene Symbol: ICOS
ICOS
0.800 GeneticVariation disease BEFREE Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. 12577056 2003
Entrez Id: 29851
Gene Symbol: ICOS
ICOS
0.800 GeneticVariation disease BEFREE Recently, the authors discovered that the homozygous loss of the ICOS in humans presents as common variable immunodeficiency, the most prevalent treated primary immunodeficiency in man. 14612664 2003
Entrez Id: 29851
Gene Symbol: ICOS
ICOS
0.800 Biomarker disease MGD ICOS is critical for CD40-mediated antibody class switching. 11343122 2001
Entrez Id: 29851
Gene Symbol: ICOS
ICOS
0.800 Biomarker disease MGD ICOS co-stimulatory receptor is essential for T-cell activation and function. 11343121 2001
Entrez Id: 29851
Gene Symbol: ICOS
ICOS
0.800 GermlineCausalMutation disease ORPHANET
Entrez Id: 29851
Gene Symbol: ICOS
ICOS
0.800 Biomarker disease CTD_human