Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE The ApoA-1 Synthesis Stimulation and intravascular Ultrasound for coronary atheroma Regression Evaluation (ASSURE; NCT01067820) study employed serial intravascular ultrasound (IVUS) measures of coronary atheroma in 281 patients treated with apabetalone or placebo for 26 weeks. 30155718 2019
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 Biomarker disease BEFREE Amyloid deposits of WT apolipoprotein A-I (apoA-I), the main protein component of high-density lipoprotein, accumulate in atherosclerotic plaques where they may contribute to coronary artery disease by increasing plaque burden and instability. 29853648 2018
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE Apolipoprotein A1 polymorphisms and risk of coronary artery disease: a meta-analysis. 28721149 2017
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 Biomarker disease BEFREE Impact of CD14 Polymorphisms on Anti-Apolipoprotein A-1 IgG-Related Coronary Artery Disease Prediction in the General Population. 29074586 2017
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 Biomarker disease BEFREE Association of High-Density Lipoprotein-Cholesterol Versus Apolipoprotein A-I With Risk of Coronary Heart Disease: The European Prospective Investigation Into Cancer-Norfolk Prospective Population Study, the Atherosclerosis Risk in Communities Study, and the Women's Health Study. 28775061 2017
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE Wild-type apoA-I protein was compared to human variants that either are protective (R173C, Milano) or lead to increased risk for ischaemic heart disease (A164S). 29051568 2017
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 AlteredExpression disease BEFREE The proinflammatory enzyme myeloperoxidase induces both oxidative modification and nitrosylation of specific residues on plasma and arterial apolipoprotein A-I to render HDL dysfunctional, which results in impaired ABCA1 macrophage transport, the activation of inflammatory pathways, and an increased risk of coronary artery disease. 26323267 2016
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 Biomarker disease CTD_human Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease. 27135400 2016
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE Significant interaction of APOE rs4420638 polymorphism with HDL-C and APOA-I levels in coronary heart disease in Han Chinese men. 26535656 2015
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE Effect of apolipoprotein A1 genetic polymorphisms on lipid profiles and the risk of coronary artery disease. 26173491 2015
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 Biomarker disease BEFREE Therefore, HDL-C and apoA1 have been investigated as therapeutic targets for coronary heart disease. 24713591 2014
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 Biomarker disease BEFREE In large meta-analyses, associations between FADS1-2-3 and carotid intima media thickness, AGPAT1 and type 2 diabetes, and APOA1 and coronary artery disease were observed. 22359512 2012
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE Increased risk of coronary artery disease in Caucasians with extremely low HDL cholesterol due to mutations in ABCA1, APOA1, and LCAT. 21875686 2012
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE APOA1/C3/A4/A5 gene cluster is closely involved in lipid metabolism, and its polymorphisms have been associated with coronary heart disease and lipid plasma levels. 21712729 2011
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 Biomarker disease BEFREE Apolipoprotein A-I (apoA-I) exerts many potentially anti-atherogenic properties and is therefore attractive for prevention and therapy of coronary heart disease. 21930241 2011
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE Mutation in APOA1 predicts increased risk of ischaemic heart disease and total mortality without low HDL cholesterol levels. 21443680 2011
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 AlteredExpression disease BEFREE Non-synonymous and regulatory single nucleotide polymorphisms (SNPs) in genes implicated in HDL-C synthesis and metabolism are likely to influence plasma HDL-C, apolipoprotein A-I (apo A-I) levels and severity of coronary atherosclerosis. 19878569 2009
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 Biomarker disease BEFREE His elder brother was also homozygous for apoA-I Tomioka with marked HDL cholesterol and apoA-I deficiency, but had no clinical evidence of coronary heart disease. 19473658 2009
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE Synergistic effect between apolipoprotein E and apolipoprotein A1 gene polymorphisms in the risk for coronary artery disease. 18398670 2008
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE Human data raised the possibility that coronary heart disease is associated with mutations in the apolipoprotein gene cluster APOA1/C3/A4 that result in multideficiency of cluster-encoded apolipoproteins and hypoalphalipoproteinemia. 16497661 2006
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 Biomarker disease BEFREE Recent evidence from a double-blind, randomized study showed that treatment with apolipoprotein A-I Milano (ApoA-I Milano) in a complex with phospholipids produced significant regression of the coronary atheroma burden in patients with acute coronary syndromes. 16039279 2005
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE The multivariate model included 512 men with coronary artery disease from the REGRESS study who were completely genotyped for eight polymorphisms selected in the univariate procedure (ie, APOA1 G(-75)A, ABCA1 C(-477)T, ABCA1 G1051A, APOC3 T3206G, APOE Arg158Cys, LIPC C(-514)T, LPL Asn291Ser and LPL Ser447Stop). 15657615 2005
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 Biomarker disease BEFREE ABCA1 gene polymorphisms but not haplotypes are involved in the variability of plasma ApoA1 and the susceptibility to coronary artery disease. 14962947 2004
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE Relationships among apolipoprotein A1 gene polymorphisms, lipid levels and coronary atherosclerosis disease. 12875674 2003
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE The association between lipoprotein(a) levels, apolipoprotein(a) size and the (TTTTA)(n) polymorphism which is located in the 5' non-coding region of the apo(a) gene was studied in 263 patients with severe coronary heart disease and 97 healthy subjects. 11408005 2001