Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.400 GeneticVariation disease BEFREE We concluded that the heterozygosity in LDLR-rs72658855and rs2228671 and T allele in LDLR rs2228671are strongly associated with an increased susceptibility to coronary artery disease. 31613733 2020
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.400 GeneticVariation disease BEFREE Familial hypercholesterolemia (FH) is an autosomal dominant disorder of lipoprotein metabolism that mainly occurs due to mutations in the low-density lipoprotein receptor gene and is characterized by increased levels of low-density lipoprotein cholesterol, leading to accelerated atherogenesis and premature coronary heart disease. 31633867 2020
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.400 Biomarker disease BEFREE The History of the WHHL Rabbit, an Animal Model of Familial Hypercholesterolemia (I) - Contribution to the Elucidation of the Pathophysiology of Human Hypercholesterolemia and Coronary Heart Disease. 31748469 2020
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.400 Biomarker disease BEFREE Familial hypercholesterolemia with early coronary atherosclerotic heart disease: A case report. 31316595 2019
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.400 GeneticVariation disease BEFREE Familial hypercholesterolemia (FH) is an inherited disease of lipoprotein metabolism caused by a defect in the LDL receptor (LDLR) leading to severe hypercholesterolemia, and associated with an increased risk of coronary heart disease and myocardial infarction. 31061510 2019
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.400 GeneticVariation disease BEFREE Variation in Coronary Atherosclerosis Severity Related to a Distinct LDL (Low-Density Lipoprotein) Profile: Findings From a Familial Hypercholesterolemia Pig Model. 31554418 2019
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.400 GeneticVariation disease BEFREE Familial hypercholesterolemia (FH) can lead to premature coronary heart disease. 31248367 2019
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.400 GeneticVariation disease BEFREE Background and Purpose- Familial hypercholesterolemia (FH) is a common autosomal dominant disease leading to increased level of serum LDL (low-density lipoprotein) cholesterol and risk of coronary heart disease. 30580708 2018
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.400 GeneticVariation disease BEFREE Familial Hypercholesterolemia (FH) is a common genetic disorder caused most often by mutations in the Low Density Lipoprotein Receptor gene (LDLr) leading to high blood cholesterol levels, and ultimately to development of premature coronary heart disease. 30413722 2018
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.400 Biomarker disease BEFREE Our findings demonstrate that the Ldlr KO hamster is an animal model of choice for human FH and has great potential in translational research of hyperlipidemia and coronary heart disease. 29289533 2018
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.400 Biomarker disease BEFREE Our findings provide new insights into LDL biology and show that targeting PCSK9 using heparan sulfate mimetics is a potential therapeutic strategy in coronary artery disease.PCSK9 interacts with LDL receptor, causing its degradation, and consequently reduces the clearance of LDL.Here, Gustafsen et al. show that PCSK9 interacts with heparan sulfate proteoglycans and this binding favors LDLR degradation. 28894089 2017
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.400 Biomarker disease BEFREE Atherosclerosis-prone apolipoprotein E (apoE) or low-density lipoprotein receptor (LDL-R) knockout (KO) mice are generally resistant to developing coronary atherosclerosis (CA) and ischemic heart disease (IHD). 27373983 2017
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.400 Biomarker disease CTD_human Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease. 27135400 2016
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.400 GeneticVariation disease BEFREE Premature coronary heart disease and autosomal dominant hypercholesterolemia: Increased risk in women with LDLR mutations. 26892126 2016
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.400 GeneticVariation disease BEFREE Molecular analysis of the LDLR gene in coronary artery disease patients from the Indian population. 26927322 2016
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.400 GeneticVariation disease BEFREE The independent variants at PCSK9, HMGCR, LPA, APOA5 and LDLR were also associated with increased risk of coronary artery disease in the expected direction. 27516387 2016
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.400 GeneticVariation disease BEFREE In this study, we firstly analyzed and found strong relationship between serum ox-HDL levels and risk factors of coronary artery diseases in clinic, then the effects of ox-HDL in initiation and progression of atherosclerosis in LDLR knockout mice were investigated by infusion of ox-HDL dissolved in chitosan hydrogel before the formation of lesions in vivo. 25912129 2015
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.400 GeneticVariation disease BEFREE Familial hypercholesterolemia (FH) is a genetic disorder with an increased risk of early-onset coronary artery disease. 25962062 2015
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.400 Biomarker disease BEFREE Familial hypercholesterolemia (FH) is a dominantly inherited disorder characterized by markedly elevated plasma low-density lipoprotein cholesterol and premature coronary heart disease. 26275368 2015
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.400 GeneticVariation disease BEFREE Meta-analysis of low density lipoprotein receptor (LDLR) rs2228671 polymorphism and coronary heart disease. 24900971 2014
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.400 Biomarker disease BEFREE Proprotein convertase subtilisin kexin type 9 (PCSK9) promotes the degradation of the low-density lipoprotein (LDL) receptor (LDLR), and its deficiency in humans results in low plasma LDL cholesterol and protection against coronary heart disease. 25070550 2014
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.400 GeneticVariation disease BEFREE Association between PCSK9 and LDLR gene polymorphisms with coronary heart disease: case-control study and meta-analysis. 23380588 2013
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.400 GeneticVariation disease BEFREE The effect of LDLR-negative genotype on CT coronary atherosclerosis in asymptomatic statin treated patients with heterozygous familial hypercholesterolemia. 23369702 2013
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.400 GeneticVariation disease BEFREE LDLR rs6511720 is associated with AAA.This finding is consistent with established effects of this variant on coronary artery disease. 24046328 2013
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.400 GeneticVariation disease BEFREE Familial hypercholesterolemia (FH), a major risk for coronary heart disease, is predominantly associated with mutations in the genes encoding the low-density lipoprotein receptor (LDLR) and its ligand apolipoprotein B (APOB). 22698793 2012