Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6272
Gene Symbol: SORT1
SORT1
0.400 Biomarker disease BEFREE Higher circulating sortilin concentration has been found in patients with coronary atherosclerosis compared to control subjects. 30634965 2019
Entrez Id: 6272
Gene Symbol: SORT1
SORT1
0.400 Biomarker disease BEFREE Circulating sortilin level as a potential biomarker for coronary atherosclerosis and diabetes mellitus. 28728579 2017
Entrez Id: 6272
Gene Symbol: SORT1
SORT1
0.400 Biomarker disease BEFREE Increased sortilin and its independent effect on circulating proprotein convertase subtilisin/kexin type 9 (PCSK9) in statin-naive patients with coronary artery disease. 27846466 2017
Entrez Id: 6272
Gene Symbol: SORT1
SORT1
0.400 GeneticVariation disease BEFREE Effect of SORT1, APOB and APOE polymorphisms on LDL-C and coronary heart disease in Pakistani subjects and their comparison with Northwick Park Heart Study II. 27112212 2016
Entrez Id: 6272
Gene Symbol: SORT1
SORT1
0.400 Biomarker disease BEFREE Examples include a role for NO signaling in myocardial repolarization and sudden cardiac death and a role for the protein sortilin in lipid metabolism and coronary artery disease. 25870159 2015
Entrez Id: 6272
Gene Symbol: SORT1
SORT1
0.400 AlteredExpression disease BEFREE The genetic loci for ATP-binding cassette transporters G5 and G8, Niemann-Pick C1-Like protein 1, sortilin-1, ABO blood-group glycosyltransferases, myosin regulatory light chain-interacting protein and cholesterol 7α-hydroxylase have all consistently been associated with LDL cholesterol levels and/or coronary artery disease in GWAS. 25887678 2015
Entrez Id: 6272
Gene Symbol: SORT1
SORT1
0.400 AlteredExpression disease BEFREE CELSR2-PSRC1-SORT1 gene expression and association with coronary artery disease and plasma lipid levels in an Asian Indian cohort. 24674750 2014
Entrez Id: 6272
Gene Symbol: SORT1
SORT1
0.400 GeneticVariation disease BEFREE Compelling evidence linking the SORT1 gene to both LDL cholesterol (LDL-C) levels and the risk of coronary artery disease emerged from the data, prompting the search for the molecules and mechanisms responsible for this association. 24500115 2014
Entrez Id: 6272
Gene Symbol: SORT1
SORT1
0.400 Biomarker disease CTD_human Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. 21378990 2011
Entrez Id: 6272
Gene Symbol: SORT1
SORT1
0.400 AlteredExpression disease BEFREE Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease. 19660754 2010
Entrez Id: 6272
Gene Symbol: SORT1
SORT1
0.400 GeneticVariation disease BEFREE We also identify SORT1 and CELSR2 as candidate susceptibility genes for a locus recently associated with coronary artery disease and plasma low-density lipoprotein cholesterol levels in the process. 18462017 2008