Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.580 AlteredExpression disease BEFREE Serum levels of monocyte chemoattractant protein-1 and all-cause and cardiovascular mortality among patients with coronary artery disease. 25786118 2016
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.580 GeneticVariation disease BEFREE Genetic variants of the monocyte chemoattractant protein-1 gene and its receptor CCR2 and risk of coronary artery disease: a meta-analysis. 21868018 2012
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.580 AlteredExpression disease BEFREE Chemokine ligand 2 genetic variants, serum monocyte chemoattractant protein-1 levels, and the risk of coronary artery disease. 20431065 2010
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.580 Biomarker disease BEFREE Epicardial fat was clearly different from substernal fat because there was a far higher expression of haptoglobin, prostaglandin D(2) synthase, nerve growth factor beta, the soluble vascular endothelial growth factor receptor (FLT1), and alpha1 glycoprotein but not of inflammatory adipokines such as monocyte chemoattractant protein-1, interleukin (IL)-8, IL-1beta, tumor necrosis factor alpha, serum amyloid A, plasminogen activator inhibitor-1, or adiponectin despite underlying coronary atherosclerosis. 20116810 2010
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.580 GeneticVariation disease BEFREE A monocyte chemoattractant protein-1 gene polymorphism is not associated with coronary artery disease in a Han Chinese population. 19332042 2009
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.580 Biomarker disease CTD_human This study demonstrates for the first time that the MCP-1 gene -2578A>G polymorphism is associated with an excess risk of coronary atherosclerosis in an asymptomatic population and demonstrates an apparent interaction with CAD risk factor burden. 16934270 2007
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.580 GeneticVariation disease BEFREE This study demonstrates for the first time that the MCP-1 gene -2578A>G polymorphism is associated with an excess risk of coronary atherosclerosis in an asymptomatic population and demonstrates an apparent interaction with CAD risk factor burden. 16934270 2007
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.580 Biomarker disease RGD Prolonged cold ischemia in rat cardiac allografts promotes ischemia-reperfusion injury and the development of graft coronary artery disease in a linear fashion. 16297799 2006
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.580 GeneticVariation disease BEFREE Currently, there is conflicting evidence regarding an association between polymorphisms in CCR2/MCP-1 and CCR5/RANTES and coronary artery disease. 15017357 2004
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.580 AlteredExpression disease BEFREE In this respect, increased expression of MCP-1 and the corresponding receptor CCR2 have been demonstrated in renal transplant rejection and coronary artery disease. 12239249 2003
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.580 Biomarker disease CTD_human Involvement of polymorphisms in the chemokine system in the susceptibility for coronary artery disease (CAD). Coincidence of elevated Lp(a) and MCP-1 -2518 G/G genotype in CAD patients. 11500196 2001
Entrez Id: 959
Gene Symbol: CD40LG
CD40LG
0.510 Biomarker disease RGD To observe the effect of electroacupuncture (EA) of "Neiguan" (PC 6) and "Xinshu" (BL 15) on levels of serum total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) and low-density lipoprotein (LDL) and expression of T cell CD 40 L and matrix metalloproteinases-9 (MMP-9) in the coronary artery in coronary heart disease (CHD) rats, so as to reveal its mechanism underlying improvement of coronary atherosclerotic heart disease. 23819214 2013
Entrez Id: 959
Gene Symbol: CD40LG
CD40LG
0.510 Biomarker disease RGD Both EA-pretreatment and routine EA of PC 6 and BL 15 can down-regulate blood TC, TG and HDL contents, raise serum HDL level and suppress the increased expression of CD 40 L and MMP-9 proteins of coronary artery tissue in rats with coronary atherosclerotic heart disease, which may contribute to their effect in improving CHD. 23819214 2013
Entrez Id: 959
Gene Symbol: CD40LG
CD40LG
0.510 Biomarker disease RGD [Effects of electroacupuncture intervention on blood lipid levels and expression of CD 40 L and MMP-9 in the coronary artery tissue in coronary heart disease rats]. 23819214 2013
Entrez Id: 959
Gene Symbol: CD40LG
CD40LG
0.510 Biomarker disease BEFREE In addition, soluble CD40L was determined by ELISA as another biomarker of coronary artery disease. 21091218 2011
Entrez Id: 959
Gene Symbol: CD40LG
CD40LG
0.510 Biomarker disease CTD_human Effect of atorvastatin on circulating proinflammatory T-lymphocyte subsets and soluble CD40 ligand in patients with stable coronary artery disease--a randomized, placebo-controlled study. 16368305 2006
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker disease BEFREE Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease: a mendelian randomisation analysis. 28408323 2018
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.400 GeneticVariation disease BEFREE Hyperlipidemia is a risk factor of arteriosclerosis, stroke, and other coronary heart disease, which has been shown to correlate with single nucleotide polymorphisms of genes essential for lipid metabolism, such as lipoprotein lipase (LPL) and apolipoprotein A5 (APOA5). 29425239 2018
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 GeneticVariation disease BEFREE Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study. 28566218 2018
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 AlteredExpression disease BEFREE Significance of lipoprotein(a) levels in familial hypercholesterolemia and coronary artery disease. 28351002 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.400 Biomarker disease BEFREE Non-nuclear estrogen receptor alpha activation in endothelium reduces cardiac ischemia-reperfusion injury in mice. 28457941 2018
Entrez Id: 5444
Gene Symbol: PON1
PON1
0.400 GeneticVariation disease BEFREE Association between the PON1 Q192R polymorphism and coronary heart disease in Chinese: A meta-analysis. 29952962 2018
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation disease BEFREE Association Patterns of Endothelial Nitric Oxide Synthase Gene (NOS3) Variant Glu298Asp with Blood Pressure and Serum Lipid Levels in Subjects with Coronary Artery Disease from Pakistan. 28620990 2018
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 GeneticVariation disease BEFREE Vascular endothelial growth factor A polymorphisms are associated with increased risk of coronary heart disease: a meta-analysis. 28430629 2018
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 GeneticVariation disease BEFREE The impact of vascular endothelial growth factor +405 C/G polymorphism on long-term outcome and severity of coronary artery disease. 27704620 2017