Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE Apolipoprotein E polymorphism, serum lipids, myocardial infarction and severity of angiographically verified coronary artery disease in men and women. 7605379 1995
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE While the common APOE polymorphism explains the majority of the locus genetic determinants of plasma lipid levels, additional SNPs in the APOC1/C2 region may contribute to CHD risk, but these effects require confirmation. 20498921 2010
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 Biomarker disease BEFREE Probucol prevents early coronary heart disease and death in the high-density lipoprotein receptor SR-BI/apolipoprotein E double knockout mouse. 12771386 2003
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE A dietary and behavioral intervention designed to lower coronary heart disease. Risk factors are unaffected by variation at the APOE gene locus. 9242968 1997
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE However, context-dependent influences of apolipoprotein E polymorphism on the risk for coronary heart disease have been reported; that is, depending on ethnic origin, gender and lifestyle, apolipoprotein E4 confers a major risk factor for coronary heart disease. 8743896 1996
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE Association of APOE gene polymorphism with lipid profile and coronary artery disease in Afro-Caribbeans. 28727855 2017
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE Effects of a frequent apolipoprotein E isoform, ApoE4Freiburg (Leu28-->Pro), on lipoproteins and the prevalence of coronary artery disease in whites. 10323784 1999
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE A further gender-based subgroup analysis revealed significant associations of APOE rs7259620 and PPAP2B rs72664392 with CHD in males (genotype: χ2=8.379, df=2, p=0.015; allele: χ2=5.190, df=1, p=0.023; recessive model: χ2=19.3, df=1, p<0.0001) and females (genotype: χ2=9.878, df=2, p=0.007), respectively. 29848931 2018
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE Apolipoprotein E (apoE) polymorphism is a genetic determinant of plasma lipid levels and of coronary heart disease (CHD) risk. 2341810 1990
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 Biomarker disease BEFREE The objective of the study was to explore whether APOE-containing HDL can attenuate the defective impact of cholesterol-overloaded HDL on the development of coronary heart disease (CHD) in humans. 29217413 2019
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE Of the 12 genes previously associated with CHD risk, in stepwise multivariate risk analysis, uncoupling protein 2 (UCP2; P = 0.0001), apolipoprotein E (APOE; P = 0.0003), lipoprotein lipase (LPL; P = 0.007), and apolipoprotein AIV (APOA4; P = 0.04) remained in the model. 17130180 2007
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE The XbaI, EcoRI and the signal peptide insertion/deletion (I/D) polymorphic sites of APOB gene, the CfoI polymorphic site of apolipoprotein E gene (APOE), and the insertion/deletion polymorphism of angiotensin I-converting enzyme (ACE) gene were studied using polymerase chain reaction (PCR) in 55 postmenopausal women with coronary artery disease (CAD) and in 119 control women of equivalent age. 9298741 1997
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE Our data suggest that genetic variation at the APOE is not a genetic factor related to the genetic susceptibility to coronary artery disease in Mexican individuals, but the role of this polymorphism in determining the lipid profile cannot be excluded. 18298348 2008
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE Genetic polymorphisms for apolipoprotein E (apo E) and methylenetetrahydrofolate reductase (MTHFR) are believed to modulate risk of coronary heart disease (CHD) acting through regulation of lipid and homocysteine metabolism, respectively. 10428303 1999
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE Apolipoprotein E polymorphism is associated with both carotid and coronary atherosclerosis in patients with coronary artery disease. 17462871 2008
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 AlteredExpression disease BEFREE The epsilon4 allele of the gene encoding apolipoprotein E (apoE) is associated with elevated serum levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), as well as an increased risk of coronary heart disease (CHD), greater disease severity, and higher CHD mortality. 17559752 2007
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE The APOE varepsilon4 allele is associated with a variety of conditions such as Alzheimer's disease, coronary artery disease, stroke and postoperative cognitive dysfunction. 11359359 2001
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 Biomarker disease BEFREE APOE ε2 represents the first significant association for multiple subclinical atherosclerosis traits across multiple ethnicities, as well as clinical coronary heart disease. 27872105 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE Butyrylcholinesterase K variant and the APOE-epsilon 4 allele work in synergy to increase the risk of coronary artery disease especially in diabetic patients. 19685167 2010
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE Apolipoprotein E polymorphism in cerebrovascular & coronary heart diseases. 20966513 2010
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 Biomarker disease RGD Establishment of a rat model with diet-induced coronary atherosclerosis. 28808185 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE We evaluated the association between APOE rs4420638 genotypes and circulating lipid concentrations along with the risk of coronary heart disease (CHD). 26535656 2015
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 Biomarker disease CTD_human Carriers of the epsilon4 allele of the apolipoprotein E gene are at a higher risk of coronary heart disease than individuals with other genotypes. 10736278 2000
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE Metabolic profile and ApoE4 genotype have effects on coronary heart disease. 31362877 2019
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE Apolipoprotein E polymorphism and coronary heart disease. 1288976 1992