Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE Apolipoprotein E Gene Variants and Risk of Coronary Heart Disease: A Meta-Analysis. 27868062 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 Biomarker disease BEFREE We used linear regression models to assess associations of APOE e4 with cognitive performance in a population-based cohort study (n = 1,434) and in a cohort of patients with coronary heart disease (n = 366), and restricted cubic splines to explore dose-response relationships between serum cholesterol levels and cognition depending on APOE polymorphism. 26495840 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE Effect of SORT1, APOB and APOE polymorphisms on LDL-C and coronary heart disease in Pakistani subjects and their comparison with Northwick Park Heart Study II. 27112212 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 Biomarker disease BEFREE The apolipoprotein E gene (APOE) is associated with coronary heart disease and stroke, but the relation with peripheral artery disease (PAD) is unknown. 26800308 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 Biomarker disease BEFREE We examined the association of circulating ApoE with cardiovascular risk factors in the two population-based studies (ELSA and NPHSII) and the relationship between ApoE concentration and coronary heart disease and stroke in all three studies. 27755538 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE We evaluated the association between APOE rs4420638 genotypes and circulating lipid concentrations along with the risk of coronary heart disease (CHD). 26535656 2015
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE Overall, the analysis showed that carriers of APOE ε2 allele decreased risk for CHD (ε2 allele vs. ε3 allele: OR = 0.82, 95% CI: 0.75-0.90, P < 0.001; ε2 carriers vs. ε3 carriers: OR = 0.81, 95% CI: 0.73-0.89, P < 0.001), compared with those carrying ε3 allele, especially in Caucasian population. 25963363 2015
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE Common variants of apolipoprotein E and cholesteryl ester transport protein genes in male patients with coronary heart disease and variable body mass index. 24402318 2015
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE In CHD trials, APOE4 carriers supplemented with LC omega-3 were categorized as differential responders to the treatment with regards to CHD risk markers. 25333200 2014
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE The association of APOE genotype with ND outcomes was assessed in a combined cohort of patients with single-ventricle CHD enrolled in the Single Ventricle Reconstruction and Infant Single Ventricle trials. 25282659 2014
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE Apolipoprotein E gene polymorphism and risk for coronary heart disease in the Chinese population: a meta-analysis of 61 studies including 6634 cases and 6393 controls. 24755673 2014
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE In the largest analysis to date, we identified no evidence for effect modification by smoking status in the association between APOE genotype and risk of CHD. 25173947 2014
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE Birthplace-bound risk of CHD was age-dependently modified by APOE ϵ4 allele, suggesting genetic differences in CHD susceptibility between early and late settlement regions in Finland and providing one explanation for the eastern high mortality. 23110590 2013
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE Association between apolipoprotein E gene polymorphism and the risk of coronary artery disease in Chinese population: evidence from a meta-analysis of 40 studies. 23826174 2013
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE On the other hand, the V162 allele may be associated with an increased risk of CHD in diabetic CHD patients due to the presence of ApoE4 allele independent of serum lipids. 23583468 2013
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE Interaction of apolipoprotein E genotype with smoking and physical inactivity on coronary heart disease risk in men and women. 22071360 2012
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE Apolipoprotein E gene polymorphism: effects on plasma lipids and risk of type 2 diabetes and coronary artery disease. 22520940 2012
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 Biomarker disease BEFREE The aim of this study was to determine the role of polymorphic variants of apolipoprotein E (APOE) and peroxisome proliferator-activated receptor delta (PPARD) genes in the development of coronary heart disease (CHD), and the PPARD and APOE gene-gene interaction in a Turkish population. 22277050 2012
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE Thus, our aim was to study the association between the APOE genotypes and incident CHD and how dietary fat and alcohol consumption modify these effects. 20688498 2011
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE Nine loci were statistically associated with incident CHD events in white participants: 9p21 (rs10757278; P=4.7 × 10(-41)), 16q23.1 (rs2549513; P=0.0004), 6p24.1 (rs499818; P=0.0002), 2q36.3 (rs2943634; P=6.7 × 10(-6)), MTHFD1L (rs6922269, P=5.1 × 10(-10)), APOE (rs429358; P=2.7×10(-18)), ZNF627 (rs4804611; P=5.0 × 10(-8)), CXCL12 (rs501120; P=1.4 × 10(-6)) and LPL (rs268; P=2.7 × 10(-17)). 22042884 2011
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE Apolipoprotein E (apoE) polymorphisms are heritable determinants of total and low-density lipoprotein cholesterol, with some authors suggesting an association between the ε4 allele and CHD. 21450082 2011
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE The apolipoprotein E gene (APOE) coding polymorphism modifies the risks of Alzheimer's disease, type 2 diabetes, and coronary heart disease. 22028770 2011
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE Effect of apolipoprotein E genotypes on incidence and development of coronary stenosis in Iranian patients with coronary artery disease. 21254242 2011
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE The ε4 allele of APOE gene was shown to be associated both with an increased risk for coronary heart disease and late-onset Alzheimer disease. 20543710 2011
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE We therefore investigated whether the LDLR locus interacted with the apolipoprotein E gene genotype on coronary heart disease risk in patients clinically diagnosed with familial hypercholesterolemia with and without LDLR mutation. 22010136 2011