Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE TT genotype of MTHFR gene is associated with CHD, and a mother or a child with T allele has a much higher risk of CHD. 30334422 2019
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE A Case-Control Study of the Association of the Polymorphisms of MTHFR and APOE with Risk Factors and the Severity of Coronary Artery Disease. 31163415 2019
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE <b>Background:</b> We performed the present study to better elucidate the correlations of methylenetetrahydrofolate reductase (<i>MTHFR</i>) and methionine synthase reductase (<i>MTRR</i>) gene polymorphisms with the risk of congenital heart diseases (CHD).<b>Methods:</b> Eligible articles were searched in PubMed, Medline, Embase and CNKI. 30333252 2018
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE Our objective was to study associations between potential environmental risk factors and methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms in CHD. 29600076 2018
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE Published studies indicated that the MTHFR gene polymorphisms C677T and A1298C are associated with congenital heart disease (CHD) risk in children, but obtained inconsistent results. 29554656 2018
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 Biomarker disease BEFREE The methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genes are two of the most important candidate genes for fetal CHD. 28758112 2017
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE In summary, our present meta-analysis supports the MTHFR 1298C allele as a risk factor for CHD. 29202788 2017
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE Our study results indicate that MTHFR gene 677T polymorphism is a genetic risk factor in the development of CHD in Chinese paediatric population. 28591039 2017
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 Biomarker disease BEFREE On multivariate analysis, the risk factors noted for CHD were presence of MTHFR C677→︀T among children and their mothers and MTRR A66→︀G among mothers. 28876333 2017
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE The aim of the current study was to explore the correlation between serum homocysteine (HCY) levels and the methylene tetrahydrofolate reductase (MTHFR) gene 677C/T polymorphism and coronary heart disease (CHD). 27051002 2016
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE The genotypes of MTHFR C677T CC, CT, and TT were 9.52%, 49.66%, and 40.82% in CHD group but 29.17%, 50% and 20.83% in control group, which were identical using both methods of HRM and PCR-RFLP, demonstrating the sensitivity and specificity of HRM were all 100%. 26990189 2016
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE Methylenetetrahydrofolate reductase C677T polymorphism is associated with increased risk of coronary artery disease in young South African Indians. 26095803 2015
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE Compared with the mothers whose MTHFR were rs1801131 AA and AC genotypes, the mothers who got a mutation of MTHFR rs1801131 CC genotypes had a 267% increase in risk of given birth of a CHD children (OR = 3.67,95%CI = 1.12-12.05). 26035828 2015
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE Results from this study indicate that the MTHFR c.1625A>C genetic variant influences the risk of CHD in the studied population. 25494855 2015
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE Our results support the MTHFR -677T allele as a susceptibility factor for CHD in the Asian maternal population and the -1298 C allele as a risk factor in the Caucasian paediatric population. 25472587 2014
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE Our data suggested that the c.1333C > T genetic polymorphism of MTHFR gene was statistically associated with the increased risk of CHD [TT versus CC: odds ratio (OR) = 2.70, 95% confidence interval (CI) 1.34-5.45, p = 0.005; T versus C: OR = 1.38, 95% CI 1.03-1.86, p = 0.032]. 24387084 2014
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE Methylenetetrahydrofolate reductase C667T polymorphism is associated with increased risk of coronary artery disease in a Chinese population. 25124382 2014
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE These preliminary findings indicate that these two MTHFR genetic polymorphisms are related with the risk of CHD in Chinese Han population, and might be potentially utilized as molecular markers. 24720776 2014
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE Association between the C677T polymorphism of the methylene tetrahydrofolate reductase (MTHFR) gene and congenital heart disease (CHD) is contentious. 23876493 2013
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE Also, homocysteine levels were significantly increased with both MTHFR 677TT and 1298CC genotypes in Egyptian children with CHD. 23933414 2013
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE The multivariate logistic regression analysis confirmed that the MTHFR-CC genotype was associated with elevated BMI levels in diabetic CHD patients (odds ratio [OR] = 5.42, P = 0.003). 24218123 2013
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE Recent meta-analyses have disproven an association between hyperhomocysteinemia and risk for coronary heart disease and between MTHFR polymorphism status and risk for venous t-hromboembolism. 23288205 2013
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE Frequency of MTHFR G1793A polymorphism in individuals with early coronary artery disease: cross-sectional study. 24310797 2013
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE Our objective was to analyze the possible association between the genotype 677T/T of the MTHFR gene and supplementation of FA in Mexican women with the presence of complex CHD in their children. 22660520 2013
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE Numerous studies have evaluated the association between the maternal C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene and congenital heart defect (CHD) risk in the Chinese Han population. 24338416 2013