Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 27245
Gene Symbol: AHDC1
AHDC1
0.010 GeneticVariation disease BEFREE Extending the phenotype of Xia-Gibbs syndrome in a two-year-old patient with craniosynostosis with a novel de novo AHDC1 missense mutation. 30858058 2020
Entrez Id: 4043
Gene Symbol: LRPAP1
LRPAP1
0.010 Biomarker disease BEFREE Syndromal craniostenosis was associated with elevated ICP, RAP was significantly lower, and skull X-rays showed more impressions (copper beaten skull). 31273495 2020
Entrez Id: 27178
Gene Symbol: IL37
IL37
0.010 AlteredExpression disease BEFREE Compared with control subjects, although mRNA and protein expression of IL-37 were upregulated in diseased tissues, especially in nasal epithelial cells, in patients with CRS without nasal polyps or in patients with chronic rhinosinusitis with nasal polyps (CRSwNP), IL-37 levels in nasal secretions were reduced in patients with eosinophilic CRSwNP. 31330219 2020
Entrez Id: 6370
Gene Symbol: CCL25
CCL25
0.010 AlteredExpression disease BEFREE To investigate the expression of CCL21 and CCL25 in different types of CRS and their significance in CRS development. 31825941 2020
Entrez Id: 1803
Gene Symbol: DPP4
DPP4
0.010 Biomarker disease BEFREE To evaluate the relationship between dipeptidyl peptidase-4 inhibitor (DPP4i) treatment and chronic rhinosinusitis (CRS) in diabetic patients. 31584671 2020
Entrez Id: 406938
Gene Symbol: MIR146A
MIR146A
0.010 Biomarker disease BEFREE Importantly, C-miR146a showed efficacy in dampening severe inflammation in clinically relevant models of chimeric antigen receptor (CAR) T-cell-induced cytokine release syndrome (CRS). 31805184 2020
Entrez Id: 6366
Gene Symbol: CCL21
CCL21
0.010 AlteredExpression disease BEFREE To investigate the expression of CCL21 and CCL25 in different types of CRS and their significance in CRS development. 31825941 2020
Entrez Id: 1846
Gene Symbol: DUSP4
DUSP4
0.010 Biomarker disease BEFREE Patients with CRS showed significant increases in the expression of ctla4 and jak1 in sinonasal tissue and blood (p < 0.05), whereas the gene expression of hla-dqa1, hla-dqb1, and dusp4 was significantly decreased in patients with CRS compared to controls (p < 0.05). 30657646 2019
Entrez Id: 6606
Gene Symbol: SMN1
SMN1
0.010 AlteredExpression disease BEFREE The associations were assessed between α‑SMA expression and the clinical features of CRS. 31322276 2019
Entrez Id: 3716
Gene Symbol: JAK1
JAK1
0.010 AlteredExpression disease BEFREE Patients with CRS showed significant increases in the expression of ctla4 and jak1 in sinonasal tissue and blood (p < 0.05), whereas the gene expression of hla-dqa1, hla-dqb1, and dusp4 was significantly decreased in patients with CRS compared to controls (p < 0.05). 30657646 2019
Entrez Id: 8626
Gene Symbol: TP63
TP63
0.010 Biomarker disease BEFREE Several genes/molecules, such as SPINK5, S100A7, S100A8/9, PCDH1, NDRG1, SPRR, and p63 are involved in modulating the physical barrier function in the context of CRS. 30925220 2019
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.010 AlteredExpression disease BEFREE Patients with CRS showed significant increases in the expression of ctla4 and jak1 in sinonasal tissue and blood (p < 0.05), whereas the gene expression of hla-dqa1, hla-dqb1, and dusp4 was significantly decreased in patients with CRS compared to controls (p < 0.05). 30657646 2019
Entrez Id: 2214
Gene Symbol: FCGR3A
FCGR3A
0.010 Biomarker disease BEFREE Overall, our results highlight the importance of FcγRIIIa-dependent IFN-γ release in preclinical cytokine release assay for the prediction of CRS risk associated with therapeutic IgG1 antibodies. 29953319 2019
Entrez Id: 51284
Gene Symbol: TLR7
TLR7
0.010 Biomarker disease BEFREE we investigated the presence of virus and the expression of Toll-like receptor (TLR) 3, TLR7, and interferon and interferon-stimulated genes (ISGs) in healthy mucosal tissue of control subjects and the inflammatory sinus mucosal tissue of CRS patients, and evaluated whether levels of interferons and ISGs might be affected by CRS-related cytokines and by treatment with macrolides, dexamethasone, or TLR3 and TLR7 agonists. 31449915 2019
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.010 GeneticVariation disease BEFREE These polygenic mouse models reinforce, in-vivo, that the combination of activation of the IGF1 pathway and disinhibition of the RUNX2 pathway leads to an increased risk of developing craniosynostosis and serves as a model of human SSC. 31442251 2019
Entrez Id: 10970
Gene Symbol: CKAP4
CKAP4
0.010 Biomarker disease BEFREE Several genes/molecules, such as SPINK5, S100A7, S100A8/9, PCDH1, NDRG1, SPRR, and p63 are involved in modulating the physical barrier function in the context of CRS. 30925220 2019
Entrez Id: 1361
Gene Symbol: CPB2
CPB2
0.010 AlteredExpression disease BEFREE Interestingly, patients with CRS and asthma showed increased TATc and TAFI levels in nasal lavage fluid compared with those in patients with CRS without asthma, especially patients with CRSwNP. 31562871 2019
Entrez Id: 6607
Gene Symbol: SMN2
SMN2
0.010 AlteredExpression disease BEFREE The associations were assessed between α‑SMA expression and the clinical features of CRS. 31322276 2019
Entrez Id: 5972
Gene Symbol: REN
REN
0.010 Biomarker disease BEFREE In addition to the hemodynamic drivers of decreased renal perfusion and increased renal vein pressure, induction of the renin-angiotensin-aldosterone system, stimulation of the sympathetic nervous system, disruption of balance between nitric oxide and reactive oxygen species, and inflammation are implicated in the pathogenesis of CRS. 31300181 2019
Entrez Id: 1043
Gene Symbol: CD52
CD52
0.010 AlteredExpression disease BEFREE We found that, in contrast to anti-CD52 antibodies (Campath-1H homolog) that elicited high level of multiple inflammatory cytokines from human blood cells in vitro, other IgG1 antibodies with CRS-inducing potential consistently induced release of a single tested cytokine, interferon (IFN)-γ, with a smaller magnitude than Campath. 29953319 2019
Entrez Id: 1493
Gene Symbol: CTLA4
CTLA4
0.010 AlteredExpression disease BEFREE Patients with CRS showed significant increases in the expression of ctla4 and jak1 in sinonasal tissue and blood (p < 0.05), whereas the gene expression of hla-dqa1, hla-dqb1, and dusp4 was significantly decreased in patients with CRS compared to controls (p < 0.05). 30657646 2019
Entrez Id: 7405
Gene Symbol: UVRAG
UVRAG
0.010 Biomarker disease BEFREE Several genes/molecules, such as SPINK5, S100A7, S100A8/9, PCDH1, NDRG1, SPRR, and p63 are involved in modulating the physical barrier function in the context of CRS. 30925220 2019
Entrez Id: 4810
Gene Symbol: NHS
NHS
0.010 Biomarker disease BEFREE The 7-year programme comprises three consecutive workstreams, designed to explore NHS care pathways through analysis of primary and secondary data sources, and to undertake a randomised controlled trial to evaluate a longer-term course of macrolide antibiotics and endoscopic sinus surgery for patients with CRS. 31014344 2019
Entrez Id: 431704
Gene Symbol: RGS21
RGS21
0.010 GeneticVariation disease BEFREE For two SNPs in a gene recently associated with bitterant signaling regulation, RGS21, there were no associations with CRS (although the frequency of the minor allele of RGS21, rs7528947, was seen to increase with increasing Lund-Mackay CT staging score). 31137020 2019
Entrez Id: 1830
Gene Symbol: DSG3
DSG3
0.010 AlteredExpression disease BEFREE DSG3 was identified to be an upregulated gene in CRS, which was further documented in CRS mice models. 31028575 2019