Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE BT-11 significantly decreases interferon gamma positive (IFNγ+) and tumor necrosis factor alpha positive (TNFα+) cluster of differentiation 4 positive (CD4+) T cells and increases forkhead box P3 positive (FOXP3+) CD4+ T cells in colonic lamina propria mononuclear cells from patients with CD and patients with UC at concentrations of 0.01 µM when treated ex vivo. 31077582 2020
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 GeneticVariation disease BEFREE Taken together, these results suggest a potential role for ZIP8 in intestinal inflammation, induced by IFNγ in the intestinal epithelial compartment, and that perturbations in negative regulation of NF-κB by ZIP8 A391T may contribute to CD pathogenesis. 31151823 2019
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression disease BEFREE Additionally, lncRNA ANRIL expression was negatively associated with Crohn's disease activity index (P = 0.002), C-reactive protein (P < 0.001) and erythrocyte sedimentation rate (P = 0.001), and associated with tumor necrosis factor-α (P < 0.001), IL-17 (P < 0.001) and interferon gamma messenger RNA levels (P = 0.004) but positively associated with IL-10 messenger RNA level (P = 0.002). 30665494 2019
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 GeneticVariation disease BEFREE The A allele of IFN-γ +874 polymorphism was overrepresented in the whole population of patients with IBD (OR 1.63; 95% CI 1.08-2.47; p = 0.020) and as well in the subpopulation of patients with CD (OR 2.14; 95% CI 1.26-3.63; p = 0.004), but not in UC. 30134230 2019
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE Using a candidate gene approach, 21 functional single-nucleotide polymorphisms (SNPs) in 14 genes in the Toll-like receptors, the inflammasome and the IFNG pathways were assessed in 482 and 256 prior anti-TNF naïve Danish patients with CD and UC, respectively. 28139755 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression disease BEFREE In the multiplex assay, serum concentrations (pg/mL) of IL-4 (9.6 ± 1.5 vs. 12.7 ± 3.0), IL-21 (14.9 ± 1.5 vs. 26.4 ± 9.1), IL-33 (14.3 ± 0.9 vs. 19.1 ± 5.3), and IFN-γ (15.2 ± 5.9 vs. 50.2 ± 42.4) were significantly lower in Crohn's disease than those in the control group. 30584414 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE We identified decreased expression of RNASET2 as a component of TL1A-mediated increase in production of IFNG and as a potential biomarker for patients with severe CD. 28400196 2017
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE We found that the frequency of IFN-γ- and IL-17-expressing CD4 T cells was significantly higher after stimulation with CD bacteria than with non-CD bacteria, while the frequency of IL-4- and IL-10-expressing CD4 T cells was significantly decreased after stimulation with CD bacteria. 29031634 2017
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE Overproduction of pro-inflammatory cytokine Interferon-γ (IFN-γ) induces the excessive apoptosis of IECs and is involved in CD development. 28476379 2017
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE Regarding miR-125b, no association with CRP, CDAI, IL-17, TNF-α, or IFN-γ was found in A-CD or in R-CD patients. miR-125a levels gradually increased in A-CD patients who achieved clinical remission (<i>P</i> = 0.009) after 3-mo treatment, whereas they remained unchanged among patients who failed to achieve remission. 29209130 2017
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE The pathway modulates interferon gamma, which induces the JAK/STAT pathway that is involved in Crohn's disease. 27622767 2016
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 GeneticVariation disease BEFREE Previous studies have shown that polymorphisms in the Toll-like receptor (TLR), the apoptosis, the IL-23/IL-17 and the interferon gamma (IFNG) pathways are associated with risk of both CD and UC. 26698117 2015
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression disease BEFREE Elevated levels of IL-4 (2.91-fold) and IL-13 (4.05-fold) mRNA were detected in the inflamed colon mucosa of patients with ulcerative colitis (UC), IFN-γ mRNA was upregulated (3.23-fold) in the inflamed colon mucosa of patients with Crohn's disease (CD), whereas upregulation of IL-17A and TL1A mRNA was present in the inflamed colon mucosa of patients with both CD and UC (IL-17A: 4.48-fold and 2.74-fold, TL1A: 3.19-fold and 3.22-fold, respectively) vs. control subjects. 26072972 2015
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE Besides gene-level CD association P-values, association with AI diseases was the strongest predictor, highlighting generalized mechanisms of inflammation, and the interferon-γ pathway particularly. 25935003 2015
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE These data are in concordance with the fact that CD has been shown to be associated with a Th1 T-cell-mediated inflammation model and high IL12/IFNγ production at histological affected sites. 25359546 2015
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE Here, we demonstrate no quantitative difference in phenotype, in vitro growth kinetics and molecular signatures to IFNγ between MSCs derived from CD and healthy individuals. 25899824 2015
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 GeneticVariation disease BEFREE Peripheral T cells of UC and Crohn's disease (CD) patients were genotyped for rs1861494 and analyzed for allele-specific and IFNG promoter methylation. 25171510 2014
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression disease BEFREE Basal levels of P2X7-R mRNA were higher in CD inflamed mucosa compared with noninflamed CD and controls and were upregulated after interferon-γ in controls. 24412990 2014
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 GeneticVariation disease BEFREE Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05). 24776844 2014
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE Utility of in vitro interferon-γ release assay in differential diagnosis between intestinal tuberculosis and Crohn's disease. 23176201 2013
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression disease BEFREE Expression of growth-related oncogene-alpha was increased in intestinal TB, while expression of interferon-gamma (IFN-) and TLR 4, 5 and 9 was increased in Crohn's disease. 23575333 2013
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression disease BEFREE The percentages of circulating Th1 (CD3+CD8-IFN-γ+) and Tc1 (CD3+CD8+IFN-γ+) cells were also higher in patients with active UC when compared with the percentages in patients with inactive UC and normal controls, although levels were lower than that in CD. 23446770 2013
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE Quantitative gene expression analysis, by real-time PCR, of IL-32, IL-1β, IL-10, TNF-α and IFN-γ was performed on ileal biopsies of 15 AS and 15 Crohn's disease (CD) patients and 10 healthy subjects (HSs). 22847681 2012
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE Elevated IL-17A levels were positively correlated with IFN-γ in both inflammatory CD and UC but IL-17A and IFN-γ were correlated with IL-23p19 in CD ileum only. 21994045 2012
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE IFN-γ is known not only to play an important role in the pathogenesis of Crohn's disease (CD), but also to increase permeability of the intestinal epithelial barrier. 22671596 2012