The aim of this association study in a large multicenter sample of alcohol-dependent individuals and controls is to investigate the role of DBH SNPs and haplotypes in AD risk and associated phenotypes (AD with MD or SA).
The aim of this association study in a large multicenter sample of alcohol-dependent individuals and controls is to investigate the role of DBH SNPs and haplotypes in AD risk and associated phenotypes (AD with MD or SA).
Molecular genetic studies point to potential risk loci of psychotic depression shared with schizoaffective disorder (1q42, 22q11, 19p13), depression, bipolar disorder, and schizophrenia (6p, 8p22, 10p13-12, 10p14, 13q13-14, 13q32, 18p, 22q11-13) and several vulnerability genes possibly contributing to an increased risk of psychotic symptoms in depression (eg, BDNF, DBH, DTNBP1, DRD2, DRD4, GSK-3beta, MAO-A).
Tyrosine-hydroxylase (TH) and dopamine-beta-hydroxylase (DBH) mRNA levels were decreased both in right and left atria, while phenylethanolamine N-methyltransferase (PNMT) mRNAs were increased in left atria and both ventricles of depression model rats.
The strength of the association of DBH genotype with depression essentially remained unchanged after correction for other variables in a multivariate model.
The strength of the association of DBH genotype with depression essentially remained unchanged after correction for other variables in a multivariate model.
In addition, since the activity of plasma and cerebrospinal fluid (CSF) dopamine beta-hydroxylase (DBH) is genetically determined, the co-occurrence of delusional depression and Parkinsonism in this patient may be related to a common underlying genetic defect that expresses itself biochemically by reduced cerebral NE metabolism.