Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 GeneticVariation disease BEFREE Differential effects of DRN GR deletion in female mice may provide insight into the greater incidence of depression and specific depression symptoms in women. 31846734 2020
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 AlteredExpression disease BEFREE Time-group interaction effects were found for several impulsivity scores, SCL-90R Global Severity Index, Paranoid Thoughts, and Depression subscales as well as for NR3C1 expression. 31812111 2020
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 PosttranslationalModification disease BEFREE Poisson regression with robust variance adjusted by gender, tobacco use, self-perceived stress, leisure activity, suicidal ideation, low cortisol levels and NR3C1 DNA methylation was performed and predicted risk factors for depression. 31731185 2020
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 Biomarker disease BEFREE The mineralocorticoid receptor (MR)/glucocorticoid receptor balance plays an important role in the pathophysiology of anxiety and depression. 30852427 2019
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 GeneticVariation disease BEFREE Pain and depressive-like behavior were measured over 14 days and brain-derived neurotrophic factor (BDNF; a factor involved in nociception and depression) and glucocorticoid receptor (GR; a stress-related receptor) expression were measured on day 14. 31815911 2019
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 Biomarker disease BEFREE Glucocorticoid receptor dysfunction orchestrates inflammasome effects on chronic obstructive pulmonary disease-induced depression: A potential mechanism underlying the cross talk between lung and brain. 30738183 2019
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 AlteredExpression disease BEFREE Considering possible confounding effects of alcohol and/or depression, we conclude that chronic cocaine use is associated with lower NR3C1 gene expression suggesting possible direct effects of the drug on the biological adaptation of stress-related genes. 29761890 2019
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 Biomarker disease BEFREE Studies investigating Glucocorticoid Receptor (GR/NR3C1) in the brain have primarily focused on the forebrain, however in recent years, the hindbrain has become a region of interest for research into the development of anxiety and depression, though the role of GR signalling in the hindbrain remains poorly characterised. 30824750 2019
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 Biomarker disease BEFREE Mothers with depression also had lower NR3C1 than other mothers (p < 0.003) but did not differ in OXTR. 29580902 2019
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 GeneticVariation disease BEFREE Methylation of the glucocorticoid receptor gene associated with depression in patients with acute coronary syndrome. 30408722 2019
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 Biomarker disease BEFREE We argue that better understanding the long-term effects of developmental stressors on PFC trkB, GR, and related factors may yield insights into risk for chronic, remitting depression and related neuropsychiatric illnesses. 30477984 2018
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 AlteredExpression disease BEFREE APPL2 Tg mice displayed higher GR activity and less capacity of neurogenesis at olfactory system with less olfactory sensitivity than WT mice, indicating that APPL2 could be a potential therapeutic target for depression and olfactory deficits. 29675572 2018
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 Biomarker disease BEFREE The glucocorticoid receptor is dysfunctional in depression, and it is a direct target of miR-124. 29484897 2018
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 GeneticVariation disease BEFREE This meta-analysis demonstrates that the NR3C1 rs41423247 homozygous mutation may be a risk factor for depression. 30278546 2018
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 GeneticVariation disease BEFREE Our findings suggest that hypermethylation at the NR3C1 exon 1F may occur in depression. 29793048 2018
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 Biomarker disease BEFREE Regulators of glucocorticoid receptor function in an animal model of depression and obesity. 29524264 2018
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 PosttranslationalModification disease BEFREE Additionally, a higher NR3C1 methylation level at CpG 2 was associated with depression incidence 2 years later in this population. 29432878 2018
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 AlteredExpression disease BEFREE In addition, six glucocorticoid receptor pathway genes (Slc22a5, Aqp1, Stat5a, Ampd3, Plekhf1, and Cyb561) were upregulated in GF mice, and of these only two (Stat5a and Ampd3) were upregulated in LPS-treated mice, whereas the shared gene, Stat5a, was downregulated in "depression microbiota" recipient mice. 30194287 2018
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 Biomarker disease BEFREE The noradrenergic system and GR pathway in the locus coeruleus may be involved in the formation of depression concomitant with sleep disturbances. 29894769 2018
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 Biomarker disease BEFREE Combining both models resulted in 22 new and confirmed HSP90-independent NR3C1 inhibitors, providing two scaffolds (i.e., pyrimidine and pyrazolo-pyrimidine), which could potentially be of interest in the treatment of depression (i.e., inhibiting the glucocorticoid receptor (i.e., NR3C1), while leaving its chaperone, HSP90, unaffected). 29658791 2018
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 Biomarker disease BEFREE The results do not support the hypothesis that GR dysregulation is aetiopathogenic in CFS and suggest that current and future endocrine cross-sectional studies in CFS may be vulnerable to the confounding influence of childhood trauma which is likely increased by comorbid depression. 29983634 2018
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 PosttranslationalModification disease BEFREE The glucocorticoid receptor gene (NR3C1) displayed different methylation patterns in chronic stress and depression. 27998510 2017
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 Biomarker disease BEFREE The sex-dependent role of the glucocorticoid receptor in depression: variations in the NR3C1 gene are associated with major depressive disorder in women but not in men. 27549215 2017
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 GeneticVariation disease BEFREE In the context of environmental stress, a functional variant in the glucocorticoid receptor co-chaperone FKBP5 gene has been repeatedly shown to increase risk for psychiatric illness, including depression. 27485401 2017
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 GeneticVariation disease BEFREE Recent human studies show that DNA methylation changes of hypothesis-driven candidate gene regions, such as the promoter of the glucocorticoid receptor and the serotonin transporter, were associated with maternal depression in peripheral tissue samples of newborns' cord blood, infants' saliva, or adults' peripheral blood. 28714605 2017