Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE The hippocampus is particularly vulnerable to altered concentrations of the pro-inflammatory cytokine interleukin-1β (IL-1β), with elevated levels implicated in the aetiology of neurodegenerative disorders such as Alzheimer's and Parkinson's, and stress-related disorders such as depression. 31604142 2020
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE BDNF levels were negatively correlated and IL-1β and TNF-α levels were positively correlated with Hamilton Depression Rating Scale-24 scores. 30616482 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE The main findings of this study indicate a functional network in which several IL-1β-related molecules in CSF influence fatigue in addition to the classical clinical factors of depression and pain. 31101054 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE Then, alterations of pro-inflammation cytokine IL1-β level and microglia activity in the hypothalamus, which are involved in the pathophysiology of depression, were examined. 30703351 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE Spearman's correlation analysis was used to analyze the correlation between PSQI, IL-1β and liver depression grade. 30651860 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE In the rat depression model, depression decreased tear secretion and increased IL-1β and TNF-α production, whereas the serotonin, TLR2, and TLR4 levels were not increased. 30695093 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE Since IL-1β and PGE<sub>2</sub> increase in serum of stressed patients and potentially trigger depression, we used an animal model of chronic unpredictable stress (CUS) to investigate the potential impact of LTB<sub>4</sub> over depression-like symptoms. 31057373 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE Furthermore, mGluR5 deficiency dramatically inhibits cytokines release from bone marrow cells, such as IL-1β, TNF-α and IL-6, alleviating proinflammatory responses in LPS-induced depression model. 30682501 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE The biological link between depression, inflammation, and CVD can be related to high levels of pro-inflammatory cytokines, such as IL-1β, TNF-α, and IL-6, released by macrophages which play a central role in the pathophysiology of both depression and CVD. 31296155 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE In the rat model and human cirrhosis a proinflammatory cytokine pattern (elevation of interferon gamma, interleukin [IL]-1β, IL-6) was registered which in humans correlated to the degree of HE and depression. 31170723 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 GeneticVariation disease BEFREE Considering the inflammatory-depression link, and that women are twice as likely to experience depression compared to men, the current study (<i>N</i> = 475 university students) examined the moderating role of three independent cytokine single nucleotide polymorphisms (SNPs; IL-1β rs16944, IL-6 rs1800795 SNP, TNF-α rs1800629) in the relationship between early-life adversity and depressive symptoms, and whether these relations differed between males and females. 30967802 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE Elevations in brain interleukin-1 beta (IL-1β) during chronic stress exposure have been implicated in behavioral and cognitive impairments associated with depression and anxiety. 30711897 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE In all subjects, the IL-1β levels were correlated with PCL scores, after controlling for covariates, including age, education, marital status and gender, trauma exposure severity and depression. 30711869 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE Compared with controls, IL-1β (pooled standardized mean difference [SMD]: 0.642; 95% confidence interval [CI]: 0.078-1.206; significant heterogeneity: I<sup>2</sup> = 86.28%) and IL-6 (pooled SMD: 0.377; 95% CI: 0.156-0.598; significant heterogeneity: I<sup>2</sup> = 88.75%) were significantly elevated in depression. 30104698 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 GeneticVariation disease BEFREE Correlation analysis between HADS score and cytokine serum levels revealed positive associations of anxiety and/or depression with IL-1β, IL-6, IL-8, and TNF-α, and a negative correlation with IL-10, suggesting that cytokines are involved in the pathophysiology of these psychological disorders in CRC patients. 28969939 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE The results of this study suggest that palmatine can alleviate the comorbidity of DNP and DP by inhibiting the expression of P2X<sub>7</sub> receptors in the hippocampus, and its action may be related to suppression of the phosphorylation of ERK1/2 and the release of TNF-α and IL-1β in the hippocampus. 29427595 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE The hippocampus is particularly vulnerable to increases in the pro-inflammatory cytokine interleukin-1β (IL-1β), a mediator of neuroinflammation, with elevated levels implicated in the aetiology of neurodegenerative diseases such as Alzheimer's and Parkinson's, and in stress-related disorders such as depression. 30217534 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE The logistic regression model and ROC curves based on serum levels of BDNF, IL-1β, and cortisol could distinguish depression from TDS in early stage, which could provide assistance to the differential diagnosis of geriatric depression and TDS. 29445283 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE Finally, the effects of chronic stress on both depression- and anxiety-like behaviors can be mimicked by exogenous intracerebroventricular (i.c.v.) administration of IL-1β in both WT and Caspase-1<sup>-/-</sup> mice. 28416811 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE In conclusion, the results of the present study suggested that AT-I exerts anti-depressant-like effects in a CUMS-induced model of depression in mice, the molecular mechanism of which is associated with the inhibition of NLRP3 inflammasome activation to decrease IL-1β production. 29434743 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE Incident depression was significantly associated with increases in IL-1β, IL-6, and IL-8 levels during the follow-up independent of relevant covariates and after applying Bonferroni corrections. 29471232 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE The level of pro-inflammatory cytokines (IL-1β, IL-6, TNF-alpha) was not related to depression. 29787856 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE Although the IL-1 molecules are traditionally considered to be classical proinflammatory cytokines, their functions are not restricted to inflammation, and they have also been shown to play a key role in a wide range of additional physiological and pathological functions, including learning modulation, sleep, pregnancy, depression, appetite, hematopoiesis, metabolism, and many others. 29247999 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE Here, the effect of FGF22 in depression and its relationship with interleukin-1β (IL-1β) were investigated in clinical, animal, and cell experiments. 28948716 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE The depressed rats showed a significant rise in serum cortisol, NO, IL-6 and IL-1β (p<0.001).TMS antagonized depression and anxiety. 28189098 2017