Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4915
Gene Symbol: NTRK2
NTRK2
0.600 Biomarker disease BEFREE Brain-derived neurotropic factor (BDNF), a neurotrophic factor, plays important regulatory roles in depression by its high-affinity tropomysin-related kinase B (TrkB) receptor. 31660632 2020
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 GeneticVariation disease BEFREE Differential effects of DRN GR deletion in female mice may provide insight into the greater incidence of depression and specific depression symptoms in women. 31846734 2020
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 GeneticVariation disease BEFREE Clinical and preclinical studies have demonstrated that depression, one of the most common psychiatric illnesses, is associated with reduced levels of neurotrophic factors, including brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF), contributing to neuronal atrophy in the prefrontal cortex (PFC) and hippocampus, and reduced hippocampal adult neurogenesis. 31830487 2020
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.600 Biomarker disease BEFREE Serum S100B can be used as a biomarker of depression. 30745657 2020
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 Biomarker disease BEFREE The proposed model is testable and implies that low levels and low variability in serum BDNF are associated with poor response to anti-depressive medications, electroconvulsive therapy, and REM sleep deprivation, in patients with depression. 31782101 2020
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 AlteredExpression disease BEFREE In PSD patients, the presence of stroke may contribute to the development of depression, including affecting the expression of BDNF. 31385340 2020
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 Biomarker disease BEFREE In addition, NR decreased the number of activated microglia in the hippocampus, and it reduced the levels of pro-inflammatory (IL-1β, IL-6, and TNF-α) and anti-inflammatory (IL-10 and TGF-β) cytokines in the brain of mice with alcohol-induced depression. 31820774 2020
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 AlteredExpression disease BEFREE Time-group interaction effects were found for several impulsivity scores, SCL-90R Global Severity Index, Paranoid Thoughts, and Depression subscales as well as for NR3C1 expression. 31812111 2020
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE The hippocampus is particularly vulnerable to altered concentrations of the pro-inflammatory cytokine interleukin-1β (IL-1β), with elevated levels implicated in the aetiology of neurodegenerative disorders such as Alzheimer's and Parkinson's, and stress-related disorders such as depression. 31604142 2020
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 Biomarker disease BEFREE Improvement in depression was correlated with increased IL-6 sR (r = -0.59 p = 0.02). 30962090 2020
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 PosttranslationalModification disease BEFREE Poisson regression with robust variance adjusted by gender, tobacco use, self-perceived stress, leisure activity, suicidal ideation, low cortisol levels and NR3C1 DNA methylation was performed and predicted risk factors for depression. 31731185 2020
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 Biomarker disease BEFREE The specific aim of this study was to explore the relationships between biomarkers of neural health: nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), immune health: interleukin 6 (IL-6), c-reactive protein (CRP), and cortisol, as well as the presence of depression, in physically active cannabis users (CU) and non-users (NU). 31319037 2020
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 AlteredExpression disease BEFREE Major depressive disorder (MDD) is associated with stress-induced immune dysregulation and reduced brain-derived neurotrophic factor (BDNF) levels in sensitive brain regions associated with depression. 31532659 2020
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
0.600 GeneticVariation disease BEFREE Increasing number of pregnant women at risk of depression are being treated with selective serotonin reuptake inhibitors (SSRI) that bind to serotonin transporters (SERT), which prevents 5-HT binding and cellular internalization, allowing for accumulation of extracellular 5-HT available to bind to 5-HT(2A) receptor (R). 31711155 2020
Entrez Id: 6530
Gene Symbol: SLC6A2
SLC6A2
0.600 AlteredExpression disease BEFREE Then, we analyzed the expression of NET correlation with inflammatory cytokines to provide a new direction for detecting the association mechanism between depression and hypertension. 30957546 2020
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 Biomarker disease BEFREE However, EA and IL-6 were not significantly associated with depression. 31541903 2020
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 GeneticVariation disease BEFREE The association between BDNF Val66Met and SI was modeled using logistic regression adjusted for age and sex, and in secondary analyses also for depression. 30329132 2020
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 AlteredExpression disease BEFREE Additionally, elevated miR-133b and inhibited CTGF could restrain apoptosis of hippocampal neurons, repress inflammatory reaction, and increase the expression of GFAP, BDNF and neurotransmitters in hippocampal tissues of depression rats, resulting in a protective impact on neural injury in depression rats. 31830619 2020
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 Biomarker disease BEFREE Importantly, early life stressors that affect BDNF production are known to predispose individuals towards the later development of depression or anxiety disorders. 31568835 2020
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 Biomarker disease BEFREE Then histone acetyltransferase (HAT), histone deacetylase (HDAC), H3K27ac, NET, TNF-α, and interleukin-6 (IL-6) were detected by western blot in nine female subjects in different depression and hypertension groups, and Chromatin immunoprecipitation-polymerase chain reaction (Chip-PCR) were used to confirm the degree of acetylation affecting on the transcription level of NET gene. 30957546 2020
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation disease BEFREE However, very few studies have so far focused on the degree to which rare variants of SLC6A4 are responsible for the depression observed in adolescent and young adult suicide patients. 31629822 2020
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 Biomarker disease BEFREE However, little is known about the relationship between memory performance and depression severity, about the course of memory performance during antidepressant treatment as well as about the relationship between memory performance and brain-derived neurotrophic factor (BDNF). 30929060 2020
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 Biomarker disease BEFREE There were no longitudinal associations between DGIH/BMI and depression, and adjustment for IL-6 and C-reactive protein did not attenuate associations between IR/BMI and depression; however, the longitudinal analyses may have been underpowered. 30854996 2020
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 Biomarker disease BEFREE The specific aim of this study was to explore the relationships between biomarkers of neural health: nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), immune health: interleukin 6 (IL-6), c-reactive protein (CRP), and cortisol, as well as the presence of depression, in physically active cannabis users (CU) and non-users (NU). 31319037 2020
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 AlteredExpression disease BEFREE Reduced levels of brain derived neurotrophic factor (BDNF), through its role in neurogenesis and neuroplasticity, may be involved in the evolution and maintenance of depression. 31364951 2020