Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 Biomarker disease BEFREE The genetic effect of Brain-derived neurotrophic factor (BDNF) on treatment response in depression is not consistent in the literature. 28578208 2018
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation disease BEFREE Prenatal maternal depression and child serotonin transporter linked polymorphic region (5-HTTLPR) and dopamine receptor D4 (DRD4) genotype predict negative emotionality from 3 to 36 months. 27427178 2018
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 Biomarker disease BEFREE Results supported the association between PR and lower depression after stress, but did not support the association between the 5-HTTLPR and elevated depression after stress. 28774788 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 Biomarker disease BEFREE Investigating the epigenetic profile of the inflammatory gene IL-6 in late-life depression. 29070016 2018
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 GeneticVariation disease BEFREE Two recent papers associated candidate genes with brooding rumination, a possible cognitive endophenotype for depression, in children ages 8-14 years.Stone et al. reported that BDNF val66met polymorphism predicted brooding in adolescence.Woody et al. reported that children carrying at least one copy of a CRHR1 TAT haplotype reported less brooding than their peers in the presence of maternal depression. 27073970 2018
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation disease BEFREE Automatic approach-avoidance tendencies as a candidate intermediate phenotype for depression: Associations with childhood trauma and the 5-HTTLPR transporter polymorphism. 29547643 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 Biomarker disease BEFREE Clinical Phenotype of Depression Affects Interleukin-6 Synthesis. 28418766 2018
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 GeneticVariation disease BEFREE Association of Val66Met polymorphism at brain derived neurotrophic factor gene with depression among Chinese adolescents after Wenchuan earthquake: An 18months longitudinal study. 28527683 2018
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 Biomarker disease BEFREE 5-HTTLPR moderates the association between attention away from angry faces and prospective depression among youth. 28325682 2018
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 Biomarker disease BEFREE Gene-environment interactions between stress and 5-HTTLPR in depression: A meta-analytic update. 29031184 2018
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation disease BEFREE The serotonin transporter-linked polymorphic region (5-HTTLPR) of the serotonin transporter gene (SLC6A4) S allele is linked to pathogenesis of depression and slower response to selective serotonin reuptake inhibitors (SSRIs); depression and SSRIs are independently associated with bone loss. 28892067 2018
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 AlteredExpression disease BEFREE Exposure of an organism to chronic psychosocial stress may affect brain-derived neurotrophic factor (BDNF) expression that has been implicated in the etiology of psychiatric disorders, such as depression. 28593903 2018
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.600 GeneticVariation disease BEFREE Early life stress (ELS) is associated with increased vulnerability for depression, changes to the corticotropin-releasing hormone (CRH) system and structural and functional changes in hippocampus. 28461011 2018
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 Biomarker disease BEFREE microRNA-124 targets glucocorticoid receptor and is involved in depression-like behaviors. 28764913 2018
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 Biomarker disease BEFREE Suppression mediates the effect of 5-HTTLPR by stress interaction on depression. 28901577 2018
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation disease BEFREE Further, we employ a design that addresses specific limitations of many prior studies that have examined the 5-HTTLPR × SLE relation, by: (a) using a within-person repeated-measures design to address fluctuations that occur within individuals over time, increase power for detecting G × E, and address GE correlation; (b) studying reports of exogenous stressful events (those unlikely to be caused by depression) to help rule out reverse causation and negativity bias, and in order to assess stressors that are more etiologically relevant to depressive symptomatology in older adults. 26330209 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 GeneticVariation disease BEFREE We sought to assess the prevalence of -889C>T IL-1α, -31T>C and -511C>T IL-1β, -330T>G IL-2 and -174G>C IL-6 genes and their association with adiposity and depression in Polish subjects. 26934083 2017
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 GeneticVariation disease BEFREE Association of BDNF Val66MET Polymorphism With Parkinson's Disease and Depression and Anxiety Symptoms. 27852165 2017
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.600 GeneticVariation disease BEFREE Association between MTHFR C677T polymorphism and depression: a meta-analysis in the Chinese population. 26681493 2017
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.600 Biomarker disease BEFREE Clinical application of DEX/CRH test and multi-channel NIRS in patients with depression. 27582123 2017
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 Biomarker disease BEFREE Serotonin (5-hydroxytryptamine, 5-HT) and brain-derived neurotrophic factor (BDNF) are two signaling molecules that have important regulatory roles in the development and plasticity of neural circuits that are known to be altered in depression. 27620841 2017
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation disease BEFREE Variability in the serotonin transporter (5-HTTLPR) gene can influence the risk of depression associated with adversity, as well as cortisol stress reactivity, although not consistently. 28024274 2017
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 Biomarker disease BEFREE Only a nominal interaction was found between life events overall and 5-HTTLPR on depression, which failed to survive correction for multiple testing. 27138797 2017
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 Biomarker disease BEFREE The sex-dependent role of the glucocorticoid receptor in depression: variations in the NR3C1 gene are associated with major depressive disorder in women but not in men. 27549215 2017
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 AlteredExpression disease BEFREE Furthermore, BDNF serum levels negatively correlated with Beck's Depression Inventory measurements (r = -0.177, p < 0.001). 26801497 2017