Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE Risk factors related to the appearance of hyperkalaemia in the CKD group were glomerular filtration rate (GFR) (P<.001), plasma creatinine (P<.001), plasma sodium (P<.001), haemoglobin (P=.028), diastolic blood pressure (P=.012), intake of ACE inhibitors and/or angiotensin ii receptor blockers (P=.008), treatment with metformin (P<.001) and diabetes (P=.045). 30898450 2020
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE Elevation of angiotensin II (Ang II) in the serum of patients with diabetes is known to promote apoptosis of islet β cells, but the underlying mechanism remains unclear. 30939192 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE A growing body of data provides strong evidence that intracellular angiotensin II (ANG II) plays an important role in mammalian cell function and is involved in the pathogenesis of human diseases such as hypertension, diabetes, inflammation, fibrosis, arrhythmias, and kidney disease, among others. 30978131 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 AlteredExpression disease BEFREE The distribution and levels of retinal angiotensin II (Ang II) and angiotensin-(1-7) (Ang-(1-7)) were evaluated by confocal imaging and quantitative immunohistochemistry during the development of streptozotocin-induced diabetes in rats. 30126320 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE Whether angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARB) could benefit patients with diabetes and albuminuria remains controversial. 29794446 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE Compared with individuals with diabetes only, those with diabetes and schizophrenia were less likely to receive high-quality diabetes care (relative risk [RR]=.91, 95% confidence interval [CI]=.88-.95) and less likely to receive several individual process performance measures of diabetes care, including blood pressure monitoring (RR=.98, CI=.96-.99), treatment with antihypertensive drugs (RR=.83, CI=.70-.97) and angiotensin-converting enzyme/angiotensin II receptor inhibitors (RR=.72, CI=.55-.93), screening for albuminuria (RR=.96, CI=.93-.99), eye examination at least once every second year (RR=.97, CI=.94-.99), and foot examination (RR=.96, CI=.93-.99). 29032706 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE In the present work, we aimed to study the sex-specific susceptibility to diabetes and direct infusion of ANGII in kidney disease progression, with a special focus on its link to ACE2 and ACE. 29884907 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE Excessive activation of AT1R by angiotensin II (Ang II) leads to cardiovascular disease and may be involved in the development of insulin resistance and diabetes. 29136335 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 GeneticVariation disease BEFREE The ACE and AGT gene polymorphisms are not associated with the progress of diabetes developing into retinopathy in Chinese patients with type 2 diabetes. 29378484 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE The aim of the present study was to analyze the conformational changes of serum albumin by glycation-"fructation"-using multiple spectroscopic techniques, such as absorption (UV-Vis), fluorescence (SFM), circular dichroism (CD) and nuclear magnetic resonance (NMR) spectroscopy and evaluate of possible alteration of binding and competition between tolbutamide (TB, a first-generation sulfonylurea oral hypoglycemic drug) and losartan (LOS, an angiotensin II receptor (AT₁) blocker used in hypertension (1st line with a coexisting diabetes)) in binding to non-glycated (HSA) and glycated (gHSA<sub>FRC</sub>) human serum albumin in high-affinity binding sites. 29258218 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE Thus, the aim of this work was to investigate the possible changes in the expression or localization of α<sub>1</sub>-AR (α<sub>1A</sub> and α<sub>1D</sub>) and angiotensin II receptors (AT<sub>1</sub> and AT<sub>2</sub>) in aorta of rats after 4 weeks of the onset of diabetes. 28072557 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 GeneticVariation disease BEFREE Patients with a positive family history and those with a negative family history had comparable genotype and allele distribution of ACE gene insertion/deletion polymorphisms and AGT gene M/T polymorphisms.A positive family history of diabetes was not associated with the RAS gene polymorphisms. 29390444 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE Both diabetes and angiotensin II (Ang II) excess trigger cardiac remodeling and dysfunction, and diabetic cardiomyopathy. 29290979 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 AlteredExpression disease BEFREE In conclusion, in mice with streptozotocin-induced diabetes and in humans with DKD, urine concentrations and enzymatic activities of several RAS components are concordantly increased, consistent with enhanced RAS activity and greater angiotensin II formation. 28468961 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE Angiotensin II is well-recognised to be a key mediator in driving the pathological events of diabetes-associated atherosclerosis via signalling through its angiotensin II type 1 receptor (AT1R) subtype. 27168137 2016
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 GeneticVariation disease BEFREE The univariate analysis revealed that the age, hypertension, family history of diabetes and AGT rs4762 contributed to the progression of CKD in ADPKD. 26482465 2016
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE Combining patch-clamp techniques and cellular biological approaches, we found that diabetes facilitated the colocalization of angiotensin II (Ang II) type 1 receptors and BK channel α-subunits (BK-α), but not BK channel β1-subunits (BK-β1), in the caveolae of coronary SMCs. 27574914 2016
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 GeneticVariation disease BEFREE In multilocus haplotype analysis, the association between frequencies of the haplotypes and AF risk was showed in AGT gene (rs7539020-rs3789678), compared 'TT' haplotype with the common 'TC' haplotype, adjusted for age, gender, LVEF, LVEDD, LAD and frequency of hypertension and diabetes. 25723521 2015
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 GeneticVariation disease BEFREE The study may conclude that the D allele polymorphism in the ACE gene and the T allele polymorphism in AGT gene may be considered as genetic risk factors for the development of nephropathy in diabetes. 24737640 2014
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE However, the specific localization of the augmented angiotensinogen in proximal tubule segments in diabetes is still unknown. 24910532 2014
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 AlteredExpression disease BEFREE Moreover, the augmented intrarenal AGT mRNA expression paralleled renal dysfunction in patients with diabetes. 24284398 2013
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 GeneticVariation disease BEFREE In patients with IBD the mutation AGT T/T was related to male sex (P<0.0259) and, marginally, to arterial hypertension (P<0.06) and diabetes (P<0.09). 20717043 2011
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 AlteredExpression disease BEFREE Diabetes also significantly increased NADPH oxidase (NOX) expression and protein nitration along with upregulation of angiotensin II (Ang II) and its receptor expression. 21487074 2011
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 GeneticVariation disease BEFREE To explore the role of genetic variants of angiotensinogen (AGT M235T), angiotensin-converting enzyme (ACE I/D), and angiotensin type 1 receptor (AT1R A1166C) as predictors of diabetes risk and to examine their combined effects on type 2 diabetes mellitus (T2DM) patients. 20580725 2010
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE Here, we investigated whether the angiotensin II receptor antagonist losartan might improve endothelial dysfunction in OLETF rats at the established stage of diabetes. 20304070 2010