HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We aimed to investigate the demographic, clinical, and biochemical features, and HLA-DRB1 alleles in new cases of diabetes affecting Bangladeshi children and adolescents <22 years of age.
|
31669629 |
2019 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Four hundred Spanish pediatric patients with recent-onset diabetes (mean age 8.9 ± 3.9 years) were analyzed for IAA, GADA, IA2A and ZnT8A pancreatic-autoantibodies and HLA-DRB1 alleles.
|
31365591 |
2019 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We aimed to investigate the demographic, clinical, and biochemical features, and HLA-DRB1 alleles in new cases of diabetes affecting children and adolescents <22 years of age.
|
30710658 |
2019 |
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
To assess the frequency of HLA class II (DPA1, DPB1, DQA1, DQB1 and DRB1) associated to susceptibility or protection toT1DM in a Bengali population of India with diabetes.
|
23441825 |
2013 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To examine human leukocyte antigen HLA DRB1-DQB1 haplotypes within a multi-ethnic cohort and assess their association with characteristics of diabetes onset.
|
22913598 |
2013 |
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1*0901 was the independent risk factor of positive antibody in T1D patients.
|
22069282 |
2011 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To assess the frequency of HLA class II (DQA1, DQB1 and DRB1) associated to susceptibility or protection toT1DM in a Brazilian racially admixtured with diabetes.
|
20073143 |
2009 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1*03-DQB1*0201/DRB1*04-DQB1*0302 (DR3/4-DQ8) siblings who share both major histocompatibility complex (MHC) haplotypes identical-by-descent with their proband siblings have a higher risk for type 1A diabetes than DR3/4-DQ8 siblings who do not share both MHC haplotypes identical-by-descent.
|
18065518 |
2008 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, we identified markers that define DRB1*1501 DQB1*0602 haplotypes conferring reduced protection from diabetes in a Swedish 13th IHW data set.
|
17445204 |
2007 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A negative association with diabetes was observed for the DQB1*0602, 0503, 0301, and 0601 alleles, as well as the DRB1*0403 subtype.
|
16629714 |
2006 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Three haplotypes were markedly associated with diabetes in Jewish Ethiopian patients: DRB1*0301 DQA1*05 DQB1*02 (OR 4.4, p < 0.001); DRB1*0404 DQA1 03 DQB1*0302 (OR 19.2, p = 0.006), and DRB1*0405 DQA1*03 DQB1*0302 (OR 87.8, p < 0.001).
|
15603874 |
2004 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Highest risk was conferred by the genotype DRB1*03-DQA1*0501-DQB1*0201/DRB1*0401-DQA1*0301-DQB1*0302 (5% absolute risk of diabetes by age 15 yr), although sensitivity was only 22.6%.
|
15292346 |
2004 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Diabetes mellitus in adults: association of HLA DRB1 and DQB1 diabetes risk alleles with GADab presence and C-peptide secretion.
|
15388265 |
2004 |
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
In Japanese type 1 susceptible HLA haplotypes, DRB1*0901-DQB1*0303 was more frequent in type 1A diabetes than fulminant diabetes (7/18 vs. 0/18, P=0.004), whereas the frequency of DRB1*0405-DQB1*0401 was similar (type 1A 4/18 vs. fulminant 6/18).
|
14581155 |
2003 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We correlated T and B cell responses to insulin in subjects with increased genetic risk (HLA-DRB1*04, DQB1*0302) for diabetes with or without islet autoantibodies (Ab+ subjects and controls, respectively) and HLA-matched patients.
|
14679078 |
2003 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Associations between the DRB1*04 alleles and prediabetic islet autoimmunity were generally in the same direction as those with diabetes.
|
14679080 |
2003 |
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
A significant decreased frequency of DRB1*0403 (p = 0.01; odds ratio [OR] = 0.20) was demonstrated in type 2 diabetic patients, and DRB1*0701 (p = 0.02; OR = 0.17) in nondiabetics with family history of diabetes.
|
12507821 |
2003 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Similarly, the DRB1*0401-DQB1*0302/(DR13)-DQB1*0603 genotype was disease predisposing, implying that DQB*0603-mediated protection from diabetes is not always dominant.
|
12889996 |
2003 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Fewer children with the diabetes-associated human leukocyte antigen DRB1*03-DQB1*02 genotype tested positive for enterovirus RNA (P=.02).
|
12721936 |
2003 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A total of 13% of the GADab(+) patients with diabetes had genotypes comprising the DRB1*1501-DQB1*0602 or *1502-*0601 and were characterized by old age at onset of diabetes, high BMI, resistance to the insulin-deficient state, low titer of GADab, and low frequency of other organ-specific autoantibodies.
|
12032105 |
2002 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The DRB1*1503-DQ6 haplotype was associated with protection from diabetes in the Jamaican population.
|
11841488 |
2002 |
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
The presence of diabetes-resistant or neutral alleles, such as HLA DQ6 (DQB1*0602) and DR2 (DRB1*1502) prevented the generation of any self-reactive responses to rat GAD.
|
11145722 |
2001 |
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our analyses indicate that the counterbalancing between susceptible DRB1 and protective DQB1, and vice versa, is a factor that may contribute to the low incidence of diabetes in Asians.
|
11241886 |
2001 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Among HLA class II haplotypes, both HLA-DRB1*03-DQA1*0501-DQB1*0201 (DR3-DQ2) and DRB1*04-DQA1*0301-DQB1*0302 (DR4-DQ8) ("at-risk class II haplotypes") were positively associated with diabetes (OR = 6.7 and 6.0, respectively) (p(c) < 0.003).
|
10819246 |
2000 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Among patients with diabetes with DQ8, Addison's disease was strongly associated with the specific DRB1 subtype, DRB1*0404 (8 of 9 patients from 8 families, in contrast to only 109 of 408 DQ8 DM patients with diabetes without Addison's disease having DRB1*0404; P < 0.001).
|
9920103 |
1999 |