Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.100 Biomarker disease BEFREE Four proteins (Scavenger receptor cysteine rich type 1 protein M130, Fatty acid binding protein 4, Plasminogen activator inhibitor 1 and Insulin-like growth factor-binding protein 2) with a previously established association with incident diabetes and 3 proteins (Cathepsin D, Galectin-4, Paraoxonase type 3) with a novel association with incident diabetes. 30670722 2019
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.100 Biomarker disease BEFREE We recently revealed that plasminogen activator inhibitor-1 (PAI-1), a serine protease inhibitor, is involved in diabetes, osteoporosis and muscle wasting induced by glucocorticoid (GC) treatment in mice. 28321652 2018
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.100 AlteredExpression disease BEFREE PAI-1 deficiency did not affect the mRNA levels of iNOS and IL-6 in F4/80- and CD11b-double-positive cells from the bone marrow of the damaged femurs decreased by diabetes in mice. 29534207 2018
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.100 Biomarker disease BEFREE We have previously demonstrated that a PAI-1 specific inhibitor alleviated diabetes-induced delays in skin and muscle repair. 29311999 2017
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.100 GeneticVariation disease BEFREE Low-moderate arsenic exposure was positively associated with baseline fibrinogen in participants with diabetes and unexpectedly inversely associated with PAI-1. 28771557 2017
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.100 AlteredExpression disease BEFREE (1) The plasma PAI-1 levels of group A (60.39 ± 17.01 ng/L), group B (68.76 ± 17.81 ng/L) and group C and (68.63 ± 18.30 ng/L) are higher than that of controls (46.26 ± 26.04 ng/L); (2) Patients with genotype 4G/4G tended to exhibit higher PAI-1 level; (3) The distribution frequency of genotype 4G/4G in group C was significantly higher than in group A (42.4% vs. 28.7%, p < 0.05) and (4) In type 2 diabetic patients, the occurrence of diabetes nephropathy in genotype 4G/4G, 4G/5G and 5G/5G is 35.0%, 30.2% and 21.4%, respectively. 26616527 2016
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.100 Biomarker disease BEFREE Compared with 55 (33.3%) individuals in whom OSAS was not confirmed, OSAS patients had prolonged CLT (+12.8%), associated with higher PAI-1 antigen (+18.1%) (after adjustment for age, diabetes, and body mass index; both P < 0.01) and similar levels of TAFIa, plasmin, or antiplasmin. 27167858 2016
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.100 Biomarker disease BEFREE Role of plasminogen activator inhibitor-1 in glucocorticoid-induced diabetes and osteopenia in mice. 25552599 2015
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.100 GeneticVariation disease BEFREE Using allelic comparison (4G vs. 5G), the PAI-1 -675 4G/5G polymorphism was observed to have no significant association with diabetes (REM OR 1.07, 95% CI 0.96, 1.20), DN (REM OR 1.10, 95% CI 0.98, 1.25), DR (REM OR 1.09, 95% CI 0.97, 1.22) or diabetic CAD risk (REM OR 1.07, 95% CI 0.81, 1.42), and similar results were obtained in the dominant, recessive and co-dominant models. 24223897 2013
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.100 AlteredExpression disease BEFREE To address this, we used type 1 diabetes mouse model induced by streptozocin to be hyperglycemic for 8 weeks, and isolated endothelial cells that were used either freshly after isolation or after 2 to 3-week cell culture in normoglycemic conditions. mRNA expression profiling in diabetic mouse endothelial cells revealed significant and persistent up-regulation of Serpine1 encoding PAI-1, the hypo-fibrinolytic mediator leading to thrombotic diseases in diabetes, along with Rock2, Fn1 and Ccl2, whereas only Serpine 1 was persistently elevated in high glucose-treated mouse endothelial cells. 23454124 2013
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.100 AlteredExpression disease BEFREE Increased levels of PAI-1 and glycated low-density lipoprotein (glyLDL) were detected in patients with diabetes. 20630999 2010
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.100 Biomarker disease BEFREE Since TGF-beta1 is well known to stimulate the PAI-1 promoter, we suggest that TGF-beta1 and PAI-1 together constitute a positive feedback loop in the development of renal fibrosis in diabetes. 19786738 2009
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.100 Biomarker disease BEFREE Plasminogen activator inhibitor type 1 (PAI-1), produced partly from liver is a risk factor for macrovascular and microvascular complications of diabetes. 18700166 2008
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.100 AlteredExpression disease BEFREE Circulating plasminogen activator inhibitor-1 levels are elevated at an early stage of impaired glucose tolerance, resulting in diabetes and metabolic syndrome. 18160587 2008
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.100 Biomarker disease BEFREE Patients most likely to benefit from PAI-1 inhibition would be those at high risk for vascular events where PAI-1 is elevated, such as is observed in obesity, diabetes and the metabolic syndrome. 17896948 2007
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.100 AlteredExpression disease BEFREE Elevated PAI-1 levels may be associated with an increased risk for diabetes as a marker for underlying endothelial dysfunction rather than by a direct effect of genetically mediated elevated levels. 16855181 2006
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.100 Biomarker disease BEFREE Increased flux through HBP is required and sufficient for some of the metabolic effects of sustained, increased glucose flux, which promotes the complications of diabetes, e.g., diminished expression of sarcoplasmic reticulum Ca(2+)-ATPase in cardiomyocytes and induction of TGF-beta and plasminogen activator inhibitor-1 in vascular smooth muscle cells, mesangial cells, and aortic endothelial cells. 16339923 2006
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.100 AlteredExpression disease BEFREE Elevated levels of plasminogen activator inhibitor-1 (PAI-1) are associated with myocardial infarction and stroke, especially in patients with diabetes. 15956119 2005
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.100 AlteredExpression disease BEFREE Its effects on ROS production, AP-1 activity, plasminogen activator inhibitor 1 (PAI-1) gene expression, and cellular proliferation and migration were measured in response to high glucose and angiotensin II (Ang II) concentrations, two major factors in the pathogenesis of atherosclerosis in patients with diabetes and hypertension. 15827742 2005
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.100 AlteredExpression disease BEFREE In 45/112 patients without the established risk factors for RVO (hyper-tension, hypercholesterolemia and diabetes) or characteristics known to be associated to increased PAI-1 activity (overweight, hypertriglyceridemia, and smoking habit) the contemporary presence of ACE DD and PAI-1 4G4G genotype was significantly associated with a risk for RVO (OR = 8.26, 95% CI 1.18-57.92; p = 0.034). 15213845 2004
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.100 GeneticVariation disease BEFREE Interaction between genotype and diabetes status was estimated for nine CVD risk factors [body fat mass (FAT), body mass index (BMI), high-density lipoprotein cholesterol (HDL-C), log-transformed fibrinogen, log-transformed triglycerides, log-transformed urinary albumin : creatinine ratio (LACR), plasminogen activator inhibitor 1 (PAI-1), systolic blood pressure (SBP), and waist-to-hip ratio (WHR)], using a maximum likelihood variance decomposition technique. 12673782 2003
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.100 Biomarker disease BEFREE Concentrations in blood of plasminogen activator inhibitor type 1 (PAI-1) and circulating free (non-esterified) fatty acids (FFA) are increased in diabetes and may accelerate atherosclerosis. 12669679 2002
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.100 GeneticVariation disease BEFREE The PAI-1 and ACE (D/I) gene polymorphisms were examined in a cohort of Chinese type 2 diabetic patients who had diabetes for an average of 14 years. 10652041 2000
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.100 Biomarker disease BEFREE Polymorphisms of angiotensin converting enzyme and plasminogen activator inhibitor-1 genes in diabetes and macroangiopathy1. 9844142 1998
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.100 AlteredExpression disease BEFREE In a logistic regression analysis controlled for age, sex, BMI, and duration of diabetes, any retinopathy was significantly associated with fasting plasma glucose concentrations (P < 0.05), 2-h postload glucose (P = 0.02), and HbA1c (P = 0.008), but not with PAI-1 activity (P = 0.48). 9250459 1997