Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 AlteredExpression group BEFREE CPE gavage reduced serum MDA content and increased SOD and GSH-Px enzyme activities in DM mice. 31011149 2019
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 Biomarker group BEFREE However, in the condition called "oxidative stress", HOCl has the capability to attack many important biomolecules such as amino acids, proteins, nucleotides, nucleic acids, carbohydrates, and lipids; these reactions could ultimately contribute to a number of diseases such as neurodegenerative diseases (AD, PD, and ALS), cardiovascular diseases, and diabetes. 31347256 2019
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 Biomarker group BEFREE BF percentage, serum PAB and serum hs-CRP were significantly higher in individuals with metabolic syndrome and diabetes versus those without metabolic syndrome and diabetes mellitus (P < 0.05), however serum SOD1 was significantly lower in individuals with metabolic syndrome (P < 0.005). 30561055 2019
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 AlteredExpression group BEFREE NAC, given after the establishment of diabetes, may offer protection against the risk for stroke by altering both systemic and vascular prothrombotic responses via enhancing platelet GSH, and GSH-dependent MG elimination, as well as correcting levels of antioxidants such as SOD1 and GPx-1. 28961512 2018
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 GeneticVariation group BEFREE Associations persisted when adjusted for diabetes at enrollment, restricted to never-smokers, and ALS deaths in the 5 years after enrollment were excluded (accounting for recent weight loss). 29658324 2018
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 AlteredExpression group BEFREE ASE reduced oxidative damage markers (TBARS, carbonyl levels and 8-isoprostane) in D and DH associated with a decrease in Nox 4 and p47 subunit expression and increase in antioxidant enzyme activity in both groups (SOD, catalase and GPx). 28105508 2018
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 Biomarker group BEFREE TNF-α, IL-1β, MDA contents in the hippocampus were decreased, and SOD contents was increased in the hippocampus of DM rats. 30524286 2018
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 AlteredExpression group BEFREE As compared to the control group, diabetes caused degenerative changes in the cerebellum with significant elevation of MDA and decrease of SOD levels and gliosis confirmed by increase the GFAP expression area fraction. 29107328 2017
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 GeneticVariation group BEFREE SOD1 -251A>G is associated with obesity independent of the presence of diabetes or dyslipidemia. 27751366 2016
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 AlteredExpression group BEFREE The oxidative stress of diabetes mellitus impairs Wnt signaling and causes cardiac outlet defects that are rescued by SOD1 overexpression. 26232087 2015
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 Biomarker group CTD_human Resveratrol exhibits differential protective effects on fast- and slow-twitch muscles in streptozotocin-induced diabetic rats. 23786522 2014
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 GeneticVariation group LHGDN Gene polymorphisms of superoxide dismutases and catalase in diabetes mellitus. 18423055 2008
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 GeneticVariation group LHGDN DNA damage and antioxidant defense in peripheral leukocytes of patients with Type I diabetes mellitus. 12787913 2003
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 GeneticVariation group BEFREE In the current studies, parameters of glomerular injury were examined in hemizygous nondiabetic transgenic mice (SOD) and streptozotocin-diabetic (D) transgenic mice (D-SOD), which overexpress human cytoplasmic Cu2+/Zn2+ superoxide dismutase (SOD-1), and in corresponding wild-type littermates (WT, D-WT) after 4 months of diabetes. 11522679 2001