Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1536
Gene Symbol: CYBB
CYBB
0.360 GeneticVariation group BEFREE TMZ treatment ameliorated diabetes-associated structural and functional alterations by inhibiting Nox2 and TRPC3 without having any effects on glucose, insulin and AGEs levels. 30962089 2019
Entrez Id: 1536
Gene Symbol: CYBB
CYBB
0.360 AlteredExpression group BEFREE The multicomponent cytosolic Nox2 has an obligatory component, Ras-related C3 botulinum toxin substrate 1 (Rac1); in diabetes, Rac1 is functionally and transcriptionally active. 30347077 2018
Entrez Id: 1536
Gene Symbol: CYBB
CYBB
0.360 Biomarker group BEFREE Blockade of NOX2 or arginase represents a strategy to prevent diabetes-induced premature EC senescence by preserving NO bioavailability. 28617308 2017
Entrez Id: 1536
Gene Symbol: CYBB
CYBB
0.360 AlteredExpression group BEFREE LV NADPH oxidase (Nox2 gene expression and activity, and lucigenin-enhanced chemiluminescence), as well as oxidative stress, were increased by diabetes, exaggerated in diabetic dnPI3K mice, and attenuated by CoQ(10). 25937176 2015
Entrez Id: 1536
Gene Symbol: CYBB
CYBB
0.360 Biomarker group CTD_human Oxidative stress-mediated thrombospondin-2 upregulation impairs bone marrow-derived angiogenic cell function in diabetes mellitus. 23723366 2013
Entrez Id: 1536
Gene Symbol: CYBB
CYBB
0.360 Biomarker group BEFREE Myocardial mRNA levels of interleukin-6, tumor necrosis factor-α, plasminogen activator inhibitor-1, angiotensin type 1 receptor, angiotensinogen, NADPH oxidase subunits (p47(phox), gp91(phox)), glutathione peroxidase-3. and connective tissue growth factor were increased in CRP/DM compared with Wt/DM. 21519150 2011
Entrez Id: 1536
Gene Symbol: CYBB
CYBB
0.360 Biomarker group BEFREE Diabetes was induced with streptozotocin in wild-type mice or NOX2 knockout mice. 18806296 2009