Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE Altered B cell homeostasis is associated with type I diabetes and carriers of the PTPN22 allelic variant. 22105996 2012
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE This significant haplotype distribution difference suggests that polymorphisms in the PTPN22 gene other than R620W are involved in either predisposition to or protection from T1D in the Japanese population. 20510318 2010
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE A functional single nucleotide polymorphism, 1858C>T, in the PTPN22 gene, encoding a tyrosine phosphatase, has been reported to be associated with type I diabetes and some other autoimmune diseases. 15759012 2005
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE A recent study of T1D cases and controls provided evidence for association between an allele of a functional single-nucleotide polymorphism (SNP) in the PTPN22 gene and T1D. 15526003 2004
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE Pancreatic autoantibodies, HLA DR and PTPN22 polymorphisms in first degree relatives of patients with type 1 diabetes and multiethnic background. 22068554 2011
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE This meta-analysis of TDT confirms that the PTPN22 C1858T polymorphism is associated with T1D susceptibility in Europeans. 23054006 2013
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE The protein tyrosine phosphatase LYP, a key regulator of TCR signaling, presents a single nucleotide polymorphism, C1858T, associated with several autoimmune diseases such as type I diabetes, rheumatoid arthritis, and lupus. 23359562 2013
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE Additionally, we show that T1D risk alleles residing at the PTPN22, IL27, IL18RAP and IL10 loci protect against CD. 20176734 2010
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 Biomarker disease BEFREE Our goals were to study the proposed association of IL-2RA /CD25 with type 1 diabetes in the Belgian population over a broad age range, and to explore possible correlations with disease phenotypes, immune markers, HLA-DQ, INS, and PTPN22. 20849903 2010
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 Biomarker disease BEFREE The joint effect of HLA and PTPN22 on type 1 diabetes risk was significantly less than multiplicative in the case-control data, but a multiplicative model could not be rejected in the trio data. 18292987 2008
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE A single-nucleotide polymorphism in the PTPN22 gene encoding the lymphoid protein tyrosine phosphatase (Lyp) has recently been identified as a functional variant associated with susceptibility to rheumatoid arthritis (RA), type 1 diabetes, and systemic lupus erythematosus. 15986374 2005
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 Biomarker disease BEFREE This work represents, to the best of our knowledge, the first study based on both case-control and family data sets, showing the joint effect of HLA, INS and PTPN22 in a T1D Caucasian population with a wide range of age at T1D onset, adding new insights to previous findings regarding data sets consisting of patients and controls <15 years at onset. 24260237 2013
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE The PTPN22 1858T allele but not variants in the proximal promoter region of IL-21 gene is associated with the susceptibility to type 1 diabetes and the presence of autoantibodies in a Brazilian cohort. 23480181 2013
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE A variant (R620W) of PTPN22 was associated with type 1 diabetes and other autoimmune diseases in Caucasians, but the variant was absent in Asians. 17452059 2007
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 Biomarker disease BEFREE Here, we contribute the first replication of the association between PTPN22 and T1D in populations from continental Italy, carried out in two independent samples of T1D patients (N = 216 and 82) and controls (N = 271 and 89). 18179648 2008
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE This is the first report demonstrating enhanced T1D in a mouse modeling human PTPN22(R620W) and the utility of CRISPR-Cas9 for direct genetic alternation of NOD mice. 27207523 2016
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE Type 1 diabetes mellitus. Comparison between the association with PTPN22 genotype and the association with ACP1-ADA1 joint genotype. 25125338 2014
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE The single nucleotide polymorphism, rs1217419, located in the second intron of the PTPN22 gene was associated with Type 1 diabetes (odds ratio 1.5, 95% CI 1.14-1.97, P = 0.003). 24117662 2014
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE Children of parents with type 1 diabetes and prospectively followed from birth for the development of islet autoantibodies and diabetes were genotyped for single-nucleotide polymorphisms at 12 type 1 diabetes susceptibility genes (ERBB3, PTPN2, IFIH1, PTPN22, KIAA0350, CD25, CTLA4, SH2B3, IL2, IL18RAP, IL10 and COBL). 22932816 2012
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE A significant association was detected between the variant genotype of the PTPN22 gene (C1858T, rs2476601) and T1DM in Kuwaiti Arabs. 29924845 2018
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 Biomarker disease BEFREE This review article is focused on the impact of SNP's in PTPN2 (protein tyrosine phosphatase, non-receptor type 2) and PTPN22 (protein tyrosine phosphatase non-receptor type 22) on the development of Crohn's disease and T1D. 26734582 2015
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE Given the modest odds ratios of known risk alleles for inflammatory diseases, these analyses do not exclude a role for the PTPN22 allele in susceptibility to CD or MS, but they do suggest that such a putative role would probably be more modest than that reported so far in T1D, RA, SLE, and AIT. 16391555 2006
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 Biomarker disease BEFREE Expert commentary: Current data suggest that PTPN22 can be a promising target for therapeutic interventions and identification of at-risk subjects in autoimmune diseases such as T1D. 27892782 2017
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 Biomarker disease BEFREE Further adjustment for the presence of PTPN22 attenuated the risk of anti-CCP-positive RA in patients with type 1 DM to an OR of 5.3 (95% CI 1.5-18.7). 19248096 2009
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE We hypothesize that the altered T-cell function because of the PTPN22(1858C>T) polymorphism is exclusively associated with GADA-positive T1D at diagnosis. 20445565 2010