Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE PTPN22 Single-Nucleotide Polymorphisms in Iranian Patients with Type 1 Diabetes Mellitus. 28375784 2018
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE Role of the C1858T polymorphism of protein tyrosine phosphatase non-receptor type 22 (PTPN22) in children and adolescents with type 1 diabetes. 26902538 2017
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE This study suggests a possible association between the T allele of PTPN22 gene and TT genotype of IL2RA with T1D in studied Egyptian children, especially, females with early onset diabetes who carried the 1858T allele. 27288719 2017
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE C1858T Polymorphism of Protein Tyrosine Phosphatase Non-receptor Type 22 (PTPN22): an eligible target for prevention of type 1 diabetes? 27892782 2017
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE The most significant association was with two T1D SNPs, rs12150079 (ZPBP2/ORMDL3/GSDMB region) (enterovirus frequency: AA 7.3%, AG 8.7%, GG 9.7%, RR = 0.86, overall p = 1.87E-02) and rs229541 (C1QTNF6/SSTR3/RAC2) (enterovirus frequency: CC 7.8%, CT 9.7%, TT 9.4%, RR = 1.13, overall p = 3.6E-02), followed by TLR8 (rs2407992) (p = 3.8E-02), TLR3 (1914926) (p = 4.9E-02), and two other T1D SNPs (IFIH1 rs3747517, p = 4.9E-02 and PTPN22, rs2476601, p = 5.3E-02). 26485223 2016
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE PTPN22 rs2476601 is associated with JIA and numerous other autoimmune diseases, and has been reported to show female-specific association with type 1 diabetes. 26291515 2016
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease GWASCAT Genome wide identification of new genes and pathways in patients with both autoimmune thyroiditis and type 1 diabetes. 25936594 2016
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 Biomarker disease BEFREE Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice. 26438525 2016
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE Among the non-HLA SNPs reported by the Type 1 Diabetes Genetics Consortium, 24% were supported in this Swedish replication set including that the increased risk of minor PTPN22 allele and high-risk HLA was modified by GAD65 autoantibodies. 26513234 2016
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 Biomarker disease BEFREE Genetic Variations of PTPN2 and PTPN22: Role in the Pathogenesis of Type 1 Diabetes and Crohn's Disease. 26734582 2016
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE Association analysis of PTPN22, CTLA4 and IFIH1 genes with type 1 diabetes in Colombian families. 25042601 2016
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE Targeted Deep Sequencing in Multiple-Affected Sibships of European Ancestry Identifies Rare Deleterious Variants in PTPN22 That Confer Risk for Type 1 Diabetes. 26631741 2016
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE Altered B cell homeostasis and toll-like receptor 9-driven response in type 1 diabetes carriers of the C1858T PTPN22 allelic variant: implications in the disease pathogenesis. 25333705 2015
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE Analysis of PTPN22 C1858T gene polymorphism in cases with type 1 diabetes of Azerbaijan, Northwest Iran. 25243643 2015
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 SusceptibilityMutation disease RGD These findings are consistent with a role for rat Ptpn22 allelic variation within Iddm26.2 in the regulation of T cell responses, and subsequently the risk for development of T1D. 25505293 2015
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE A novel single nucleotide polymorphism in the protein tyrosine phosphatase N22 gene (PTPN22) is associated with Type 1 diabetes in a Chinese population. 24117662 2015
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 SusceptibilityMutation disease RGD Furthermore, clinical assessment of both an F2(BBDP × ACI.1u.Lyp) cohort and Iddm26.2 congenic BBDP sublines has revealed an association of Ptpn22 with T1D. 25505293 2015
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease GWASCAT Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers. 25751624 2015
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE Association of PTPN22+1858C/T polymorphism with Type 1 diabetes in the North Indian population. 24913133 2015
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 SusceptibilityMutation disease RGD A functional polymorphism of Ptpn22 is associated with type 1 diabetes in the BioBreeding rat. 25505293 2015
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 Biomarker disease BEFREE These findings confirm the role of PTPN22 and CD28 involved in the T cell activation pathway in the development of T1D in Tunisian families. 25448703 2015
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 SusceptibilityMutation disease RGD The R620W variant of PTPN22 is one of the major genetic risk factors for several autoimmune disorders including type 1 diabetes (T1D) in humans. 25505293 2015
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 Biomarker disease BEFREE The absence of autoimmunity-associated PTPN22 alleles was also demonstrated in latent autoimmune diabetes in adults, which suggests that the slow kinetics of the onset of autoantibodies is subject to a regulation that is different from that experienced in type 1 diabetes and other autoimmune disorders. 25896041 2015
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 SusceptibilityMutation disease RGD Specifically, in both cases, T1D risk is significantly greater in BBDP Ptpn22 homozygous and heterozygous animals. 25505293 2015
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 Biomarker disease BEFREE These results confirm the involvement of PTPN22 and CD28 genes in the genetic susceptibility to T1D. 24103478 2014