Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.700 AlteredExpression disease BEFREE This suggests that treatment of adiponectin effectively improves testicular functions by increasing expression of insulin receptor-mediated increased transport of energy substrate (glucose and lactate) and a marked reduction in oxidative stress are the possible mechanism by which adiponectin effectively improves testicular function in T2D mice. 31676315 2020
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.700 GeneticVariation disease BEFREE Correction to: Functional Polymorphism Located in the microRNA Binding Site of the Insulin Receptor (INSR) Gene Confers Risk for Type 2 Diabetes Mellitus in the Bangladeshi Population. 30062661 2019
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.700 Biomarker disease BEFREE Disruption of INSR-coupled activities has been identified in a wide range of insulin resistance-related diseases such as T2DM. 31658625 2019
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.700 AlteredExpression disease BEFREE PBMCs incubated for 1 hour with plasma from T2DM and pre-T2DM participants had significantly lower levels of insulin receptor density compared to those incubated with plasma from control participants (<i>p</i> < 0.001). 30964398 2019
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.700 GeneticVariation disease BEFREE Our study showed that the miRNA binding site polymorphism rs1366600 located at the 3'-UTR region of the INSR gene is associated with increased risk of T2DM in Bangladeshi individuals. 29971619 2019
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.700 AlteredExpression disease BEFREE In this review, we discuss the role of insulin and the INSR in the development and endocrine activity of adipose tissue and the pharmacological implications for the management of obesity and type 2 diabetes. 30754657 2019
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.700 AlteredExpression disease BEFREE The results described here support restoration of IR expression as a safe and effective T2DM therapeutic with a long-lasting profile. 31391336 2019
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.700 AlteredExpression disease BEFREE Beyond these physiological roles of insulin, a shared feature between the periphery and CNS is that decreases in insulin receptor activity and signaling (i.e. insulin resistance) contributes to the pathological consequences of type 2 diabetes (T2DM) and obesity. 31028829 2019
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.700 Biomarker disease BEFREE Abbreviations: AC: adenylyl cyclase; AMPK: AMP-activated protein kinase; βAR: β-adrenergic receptor; CA: catecholamine; cAMP: cyclic adenosine monophosphate; cGMP: cyclic guanosine monophosphate; DPP-4: dipeptidyl peptidase-4; ERK: extracellular signal-regulated kinase; GC: guanylyl cyclase; GH: growth hormone; GLP-1: glucagon-like peptide-1; GLUT: glucose transporter; HSL: hormone-sensitive lipase; IR: insulin receptor; IRS: insulin receptor substrate; MAPK: mitogen-activated protein kinase; MEK: MAPK/ERK kinase; MG: maltase-glucoamylase; NP: natriuretic peptide; NPR: natriuretic peptide receptor; mTORC2: mechanistic target of rapamycin complex-2; PC: proanthocyanidin; PI3K: phosphoinositide 3-kinase; PKA: cAMP-dependent protein kinase; PKB (AKT): protein kinase B; PKG: cGMP-dependent protein kinase; PPARγ: peroxisome proliferator-activated receptor-γ; SGLT1: sodium-dependent glucose transporter 1; SI: sucrase-isomaltase; T2DM: type 2 diabetes mellitus; TNFα: tumor necrosis factor-α. 30773997 2019
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.700 Biomarker disease BEFREE The pathophysiology of type 2 diabetes mellitus (T2D) is characterized by reduced or absent insulin receptor (INSR) responsiveness to its ligand, elevated hepatic glucose output and impaired glucose uptake in peripheral tissues, particularly skeletal muscle. 31378829 2019
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.700 Biomarker disease BEFREE Mitsugumin 53 (MG53 or TRIM72), a striated muscle-specific E3 ligase, promotes ubiquitin-dependent degradation of the insulin receptor and insulin receptor substrate-1 and subsequently induces insulin resistance, resulting in metabolic syndrome and type 2 diabetes mellitus (T2DM). 30586741 2019
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.700 Biomarker disease BEFREE The Protein Tyrosine Phosphatase (PTP1b) is the main enzyme involved in insulin receptor desensitization and has become a drug target for the treatment of Diabetes type II. 30714526 2019
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.700 Biomarker disease BEFREE Mulberry leaf active components alleviate type 2 diabetes and its liver and kidney injury in db/db mice through insulin receptor and TGF-β/Smads signaling pathway. 30780108 2019
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.700 Biomarker disease BEFREE Insulin therapy is often needed to overcome insulin receptor resistance in type 2 diabetes; however, the impact of providing additional insulin to already hyperinsulinemic subjects is not clear. 30249002 2018
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.700 GeneticVariation disease BEFREE Fetuin-A is a physiological inhibitor of insulin receptor tyrosine kinase and thus associated with insulin resistance, metabolic syndrome, and an increased risk for type 2 diabetes mellitus (T2DM). 29071522 2018
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.700 Biomarker disease BEFREE We worked with a transgenic rat model of type 2 diabetes mellitus (Tet29) in which the insulin receptor is knocked down by doxycycline-induced RNA interference. 29610268 2018
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.700 Biomarker disease BEFREE Allosteric modulation of the insulin receptor (IR) with monoclonal antibodies (mAbs) can enhance insulin sensitivity and restore glycemic control in animal models of T2D. 29453154 2018
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.700 Biomarker disease BEFREE Our studies of the molecular pathogenesis of type 2 diabetes, focused on interaction between insulin receptor and GM3 in membrane microdomains, led to a novel concept: type 2 diabetes and certain other lifestyle-related diseases are membrane microdomain disorders resulting from aberrant expression of gangliosides. 29747813 2018
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.700 AlteredExpression disease BEFREE Serum lipid profiles were determined, and the effects on T2DM-related gene expression and insulin receptor signaling pathway were investigated. 29777831 2018
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.700 Biomarker disease BEFREE Promoting the induction of gluconeogenic genes and blocking that of insulin receptor substrate (Irs)2 in hepatocytes contributes to the pathogenesis of type 2 diabetes. 30250231 2018
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.700 Biomarker disease BEFREE Chronic inflammation contributes to the development of type 2 diabetes mellitus by targeting the insulin receptor substrate protein-1 (IRS-1) signaling pathway. 30562745 2018
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.700 Biomarker disease BEFREE Using hepatic Golgi/endosomes fractions, we established a proteome of insulin receptor-containing endosomes that allowed the study of physical protein interaction networks on a type 2 diabetes background. 30300385 2018
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.700 Biomarker disease BEFREE We used the transgenic Tet29 diabetes rat model with an inducible knock down of the insulin receptor <i>via</i> RNA interference upon application of doxycycline (DOX) leading to insulin resistant type II diabetes. 29896157 2018
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.700 Biomarker disease BEFREE In diabetes, solid experimental evidence shows that fetuin-A binds the β-subunit of the insulin receptor to attenuate insulin signaling, thereby contributing to insulin resistance in type 2 diabetes mellitus (T2DM). 30060600 2018
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.700 AlteredExpression disease BEFREE In such a case, it is important to develop pharmacological interventions that directly restore plasma insulin levels, insulin receptor function, and hexokinase activity, thereby avoiding damage to neural tissue that is associated with cognitive deficits in diabetic patients, particularly patients with type-2 diabetes. 28673577 2017